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Details on Person UniProt:P08572 COL4A2
| Class:Id | ReferenceGeneProduct:51162 |
|---|---|
| _chainChangeLog | signal peptide:1-25 added on Fri February 6 2015;propeptide:26-183 added on Fri February 6 2015;chain:184-1712 added on Fri February 6 2015;chain:1486-1712 added on Fri February 6 2015 |
| _displayName | UniProt:P08572 COL4A2 |
| _timestamp | 2024-11-03 20:09:24 |
| chain | signal peptide:1-25 propeptide:26-183 chain:184-1712 chain:1486-1712 |
| checksum | E0DABEEAB349D8AF |
| comment | FUNCTION Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.FUNCTION Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.SUBUNIT There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network. Interacts with EFEMP2 (By similarity).INTERACTION Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain.PTM Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.PTM Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.PTM The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues.PTM Proteolytic processing produces the C-terminal NC1 peptide, canstatin.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.SIMILARITY Belongs to the type IV collagen family. |
| description | recommendedName: fullName evidence="13"Collagen alpha-2(IV) chain component recommendedName: Canstatin /component |
| geneName | COL4A2 |
| identifier | P08572 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Angiogenesis Basement membrane Bromination Collagen Direct protein sequencing Disease variant Disulfide bond Extracellular matrix Glycoprotein Hydroxylation Proteomics identification Reference proteome Repeat Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | COL4A2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992963] ENSEMBL:ENSG00000134871 COL4A2 [Homo sapiens] |
| secondaryIdentifier | CO4A2_HUMAN Q14052 Q548C3 Q5VZA9 Q66K23 |
| sequenceLength | 1712 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:215926] COL4A2(184-1712) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:1980177] COL4A2(26-1712) [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:2022089] 3x4Hyp-COL4A2(26-1712) [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:2022422] 3Hyp-COL4A2(26-1712) [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:2022478] 5Hyl-COL4A2(26-1712) [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:2022524] 3x4Hyp-3Hyp-COL4A2(26-1712) [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:2022964] 3x4Hyp-3Hyp-5Hyl-COL4A2(26-1712) [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:2022983] 3x4Hyp-5Hyl-COL4A2(26-1712) [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:2023517] GalHyl-COL4A2(26-1712) [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:2023568] 3x4Hyp-3Hyp-GalHyl-COL4A2(26-1712) [endoplasmic reticulum lumen] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:2022079] (2S,4R)-4-hydroxyproline at unknown position [ModifiedResidue:2022434] (2S,3S)-3-hydroxyproline at unknown position [ModifiedResidue:2022502] (2S,5R)-5-hydroxylysine at unknown position [ModifiedResidue:2023531] O5-galactosyl-L-hydroxylysine at unknown position [ModifiedResidue:2023623] O5-glucosylgalactosyl-L-hydroxylysine at unknown position [GroupModifiedResidue:2682386] (2S,5R)-5-hydroxylysine (sulfilimine bond) at unknown position [GroupModifiedResidue:2682395] (2S,5R)-5-hydroxylysine (sulfilimine bond) at unknown position [GroupModifiedResidue:2682406] (2S,5R)-5-hydroxylysine (sulfilimine bond) at unknown position |
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No pathways have been reviewed or authored by UniProt:P08572 COL4A2 (51162)
