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Details on Person UniProt:P40259 CD79B
| Class:Id | ReferenceGeneProduct:51120 |
|---|---|
| _chainChangeLog | signal peptide:1-28 added on Fri February 6 2015;chain:29-229 added on Fri February 6 2015 |
| _displayName | UniProt:P40259 CD79B |
| _timestamp | 2024-11-03 19:44:58 |
| chain | signal peptide:1-28 chain:29-229 |
| checksum | C467175567D10883 |
| comment | FUNCTION Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.SUBUNIT Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains (PubMed:35981043). Interacts with LYN (By similarity).INTERACTION Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.ALTERNATIVE PRODUCTS B-cells.DOMAIN The transmembrane helices of CD79A and CD79B chains and two IgM heavy chains assembly in a four-helix bundle structure that appears to be conserved among different BCR isotypes.PTM Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK.DISEASE The disease is caused by variants affecting the gene represented in this entry.ONLINE INFORMATION CD79B mutation db |
| description | recommendedName: B-cell antigen receptor complex-associated protein beta chain alternativeName: B-cell-specific glycoprotein B29 alternativeName: Ig-beta alternativeName: Immunoglobulin-associated B29 protein cdAntigenNameCD79b/cdAntigenName |
| geneName | CD79B B29 IGB |
| identifier | P40259 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Adaptive immunity Alternative splicing Cell membrane Direct protein sequencing Disease variant Disulfide bond Glycoprotein Immunity Immunoglobulin domain Membrane Phosphoprotein Proteomics identification Receptor Reference proteome Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CD79B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998209] ENSEMBL:ENSG00000007312 CD79B [Homo sapiens] |
| secondaryIdentifier | CD79B_HUMAN Q53FS2 Q9BU06 |
| sequenceLength | 229 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:144843] UniProt:P40259-2 CD79B [Homo sapiens] [ReferenceIsoform:403944] UniProt:P40259-1 CD79B [Homo sapiens] [ReferenceIsoform:8967792] UniProt:P40259-3 CD79B [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:197156] CD79B [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:983634] p-Y196,Y207-CD79B [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:9940589] CD79B (GC B cell) [plasma membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:983533] O4'-phospho-L-tyrosine (unknown) at 207 [ModifiedResidue:983598] O4'-phospho-L-tyrosine at 199 [ModifiedResidue:983665] O4'-phospho-L-tyrosine at 196 |
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No pathways have been reviewed or authored by UniProt:P40259 CD79B (51120)
