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Details on Person UniProt:Q16581 C3AR1
| Class:Id | ReferenceGeneProduct:51092 |
|---|---|
| _chainChangeLog | chain:1-482 added on Fri February 6 2015 |
| _displayName | UniProt:Q16581 C3AR1 |
| _timestamp | 2026-02-20 22:41:26 |
| chain | chain:1-482 |
| checksum | 287E219D98CED203 |
| comment | FUNCTION Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a, stimulating chemotaxis, granule enzyme release and superoxide anion production (PubMed:12871936, PubMed:37852260, PubMed:8702752). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:37852260). C3AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase (PubMed:37852260).SUBUNIT Interacts with VGF-derived peptide TLQP-21 (By similarity). Interacts (when phosphorylated) with ARRB1; the interaction is associated with internalization of the receptor and short-term desensitization to the ligand (PubMed:38175886).INTERACTION Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells (PubMed:8605247, PubMed:8765043, Ref.3). Mostly expressed in lymphoid tissues (PubMed:8605247, PubMed:8765043, Ref.3).PTM Phosphorylation of the C-terminus by GRK2 or GRK3 promotes association with beta-arrestin (ARRB1), leading to receptor desensitization and negative regulation of G-protein coupled receptor signaling.PTM Among the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin.PTM O-glycosylated.SIMILARITY Belongs to the G-protein coupled receptor 1 family. |
| description | recommendedName: C3a anaphylatoxin chemotactic receptor shortName evidence="20"C3AR shortName: C3a-R |
| geneName | C3AR1 AZ3B C3R1 HNFAG09 |
| identifier | Q16581 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Chemotaxis Disulfide bond G-protein coupled receptor Glycoprotein Membrane Phosphoprotein Proteomics identification Receptor Reference proteome Sulfation Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | C3AR1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991741] ENSEMBL:ENSG00000171860 C3AR1 [Homo sapiens] |
| secondaryIdentifier | C3AR_HUMAN O43771 Q92868 |
| sequenceLength | 482 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:444727] C3AR1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:6799516] C3AR1 [specific granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:6799517] C3AR1 [azurophil granule membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q16581 C3AR1 (51092)
