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Query author contributions in Reactome

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Details on Person BRCA1 [nucleoplasm]

Class:IdEntityWithAccessionedSequence:50949
_displayNameBRCA1 [nucleoplasm]
_timestamp2010-02-26 18:53:35
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:75141] Matthews, L, 2003-08-11 05:43:00
endCoordinate1863
modified[InstanceEdit:75141] Matthews, L, 2003-08-11 05:43:00
[InstanceEdit:83604] Matthews, L, 2003-11-23 12:20:00
[InstanceEdit:110398] Matthews, L, 2004-02-01 16:00:00
[InstanceEdit:113515] Schmidt, EE, 2004-06-07 04:20:06
[InstanceEdit:532419] Matthews, L, 2010-02-26
[InstanceEdit:3132750] Wu, G, 2013-02-13
nameBRCA1
Breast cancer type 1 susceptibility protein
referenceEntity[ReferenceGeneProduct:50950] UniProt:P38398 BRCA1 [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:366459] R-HSA-50949.1
startCoordinate1
(activeUnit)[CatalystActivity:9701027] ubiquitin-protein transferase activity of BRCA1:BARD1 [nucleoplasm]
(hasComponent)[Complex:110402] BRCA1:53BP1 complex at site of DNA double-strand break [nucleoplasm] [Homo sapiens]
[Complex:517917] BRCA1:BRCA2:PALB2 [nucleoplasm] [Homo sapiens]
[Complex:912476] Synaptonemal Complex:BRCA1 [nucleoplasm] [Homo sapiens]
[Complex:912507] Meiotic single-stranded DNA complex [nucleoplasm] [Homo sapiens]
[Complex:5659802] BRCA1:BARD1 [nucleoplasm] [Homo sapiens]
(hasMember)[CandidateSet:6797713] BRCA1, ATR, FANCD2, FANCI, ATM, MDC1, CHEK1, RAD51D [nucleoplasm] [Homo sapiens]
[CandidateSet:8852085] RING-type E3 ubiquitin ligase [nucleoplasm] [Homo sapiens]
(input)[Reaction:447346] Formation of the BRCA1-PALB2-BRCA2 complex
[Reaction:912467] BRCA1 is recruited to unsynapsed regions [Homo sapiens]
[BlackBoxEvent:912503] Formation of meiotic single-stranded DNA invasion complex [Homo sapiens]
[Reaction:2997616] PIAS1,4 SUMOylates BRCA1 with SUMO2,3 [Homo sapiens]
[Reaction:2997709] PIAS1,4 SUMOylates BRCA1 with SUMO1 [Homo sapiens]
[Reaction:5659781] BRCA1 forms a heterodimer with BARD1 [Homo sapiens]
[FailedReaction:9699163] Defective BARD1 does not bind BRCA1 [Homo sapiens]
[Reaction:9974238] CRL4A-DCAF8L1 polyubiquitinates BRCA1 [Homo sapiens]
(normalEntity)[EntityFunctionalStatus:9663211] loss_of_function of BRCA1 mutants (BARD1 binding) [nucleoplasm]
(output)[BlackBoxEvent:9007605] BRCA1 gene expression is inhibited by E2F6 [Homo sapiens]
[Reaction:9700998] BAP1 disrupts the BRCA1:BARD1 heterodimer [Homo sapiens]
[BlackBoxEvent:9926521] MITF-M-dependent BRCA1 gene expression [Homo sapiens]
(regulator)[NegativeRegulation:9817830] Negative regulation by 'BRCA1 [nucleoplasm]'
(updatedInstance)[_UpdateTracker:9874775] Update Tracker - [EntityWithAccessionedSequence:50949] BRCA1 [nucleoplasm] - v44:[modifyEndCoordinate]
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No pathways have been reviewed or authored by BRCA1 [nucleoplasm] (50949)
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