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Details on Person UniProt:Q9H583 HEATR1
| Class:Id | ReferenceGeneProduct:50928 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:1-2144 added on Fri February 6 2015;chain:2-2144 added on Fri February 6 2015;initiator methionine:1 for 50928 removed on Fri Nov 03 2023;initiator methionine: for 50928 added on Fri Nov 03 2023;initiator methionine: for 50928 removed on Fri Aug 15 2025;initiator methionine:1 for 50928 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q9H583 HEATR1 |
| _timestamp | 2025-08-15 21:00:09 |
| chain | chain:1-2144 initiator methionine:1 chain:2-2144 |
| checksum | 7590EEA17A5FF39D |
| comment | FUNCTION Ribosome biogenesis factor; required for recruitment of Myc to nucleoli (PubMed:38225354). Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Involved in neuronal-lineage cell proliferation (PubMed:38225354).SUBUNIT Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (PubMed:17699751, PubMed:34516797). Interacts with MYC; the interaction is required for localization of MYC to the nucleolus (PubMed:38225354).INTERACTION The protein described in this entry is essential for the tumorigenic capacity of precancerous glioblastoma stem cells and their proliferation during tumorigenesis (PubMed:38225354). The protein is overexpressed in patient derived glioblastoma tissue compared to control brains (PubMed:38225354). Overexpression is more pronounced in high grade glioblastomas compared to low grade samples, and expression levels inversely correlate with patient survivability (PubMed:38225354).SIMILARITY Belongs to the HEATR1/UTP10 family. |
| description | recommendedName: HEAT repeat-containing protein 1 alternativeName: Protein BAP28 alternativeName: U3 small nucleolar RNA-associated protein 10 homolog component recommendedName: HEAT repeat-containing protein 1, N-terminally processed /component |
| geneName | HEATR1 BAP28 UTP10 |
| identifier | Q9H583 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Ribonucleoprotein Ribosome biogenesis rRNA processing Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | HEATR1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991888] ENSEMBL:ENSG00000119285 HEATR1 [Homo sapiens] |
| secondaryIdentifier | HEAT1_HUMAN Q5T3Q8 Q6P197 Q9NW23 |
| sequenceLength | 2144 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:6790721] HEATR1 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9H583 HEATR1 (50928)
