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Details on Person UniProt:O00238 BMPR1B
| Class:Id | ReferenceGeneProduct:50908 |
|---|---|
| _chainChangeLog | signal peptide:1-13 added on Fri February 6 2015;chain:14-502 added on Fri February 6 2015 |
| _displayName | UniProt:O00238 BMPR1B |
| _timestamp | 2025-02-21 19:25:44 |
| chain | signal peptide:1-13 chain:14-502 |
| checksum | B283D9BF45535C79 |
| comment | FUNCTION On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction.CATALYTIC ACTIVITY L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)CATALYTIC ACTIVITY L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl-[receptor-protein] + ADP + H(+)COFACTOR Interacts with high affinity with GDF5; positively regulates chondrocyte differentiation (PubMed:24098149). Interacts with SCUBE3 (PubMed:33308444). Interacts with TSC22D1/TSC-22 (PubMed:21791611). Interacts with TGFBR3 (PubMed:19726563).INTERACTION Autophosphorylated.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. |
| description | recommendedName: Bone morphogenetic protein receptor type-1B shortName: BMP type-1B receptor shortName: BMPR-1B ecNumber evidence="2"2.7.11.30 cdAntigenNameCDw293/cdAntigenName |
| geneName | BMPR1B |
| identifier | O00238 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing ATP-binding Cell membrane Chondrogenesis Disease variant Disulfide bond Dwarfism Kinase Magnesium Manganese Membrane Metal-binding Nucleotide-binding Proteomics identification Receptor Reference proteome Serine/threonine-protein kinase Signal Transferase Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | BMPR1B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998187] ENSEMBL:ENSG00000138696 BMPR1B [Homo sapiens] |
| secondaryIdentifier | BMR1B_HUMAN B2R953 B4DSV1 P78366 |
| sequenceLength | 502 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8965081] UniProt:O00238-1 BMPR1B [Homo sapiens] [ReferenceIsoform:8965082] UniProt:O00238-2 BMPR1B [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:201657] BMPR1B [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:201814] p-4S-BMPR1B [plasma membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:201813] O-phospho-L-serine at unknown position |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O00238 BMPR1B (50908)
