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Details on Person UniProt:Q13873 BMPR2
| Class:Id | ReferenceGeneProduct:50904 |
|---|---|
| _chainChangeLog | signal peptide:1-26 added on Fri February 6 2015;chain:27-1038 added on Fri February 6 2015 |
| _displayName | UniProt:Q13873 BMPR2 |
| _timestamp | 2025-05-21 21:41:22 |
| chain | signal peptide:1-26 chain:27-1038 |
| checksum | 1389923CE574B913 |
| comment | FUNCTION On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed:12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA (PubMed:24018044).CATALYTIC ACTIVITY L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)CATALYTIC ACTIVITY L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl-[receptor-protein] + ADP + H(+)COFACTOR Interacts with GDF5 (PubMed:21976273). Interacts with BMP4 (PubMed:29212066). Interacts with SCUBE3 (PubMed:33308444). Interacts with TSC22D1/TSC-22 (PubMed:21791611). Interacts with activin A/INHBA (PubMed:24018044).INTERACTION Highly expressed in heart and liver.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. |
| description | recommendedName: Bone morphogenetic protein receptor type-2 shortName: BMP type-2 receptor shortName: BMPR-2 ecNumber: 2.7.11.30 alternativeName: Bone morphogenetic protein receptor type II shortName: BMP type II receptor shortName: BMPR-II |
| geneName | BMPR2 PPH1 |
| identifier | Q13873 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing ATP-binding Cell membrane Disease variant Disulfide bond Glycoprotein Kinase Magnesium Manganese Membrane Metal-binding Nucleotide-binding Phosphoprotein Proteomics identification Receptor Reference proteome Serine/threonine-protein kinase Signal Transferase Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | BMPR2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993489] ENSEMBL:ENSG00000204217 BMPR2 [Homo sapiens] |
| secondaryIdentifier | BMPR2_HUMAN Q13161 Q16569 Q4ZG08 Q53SA5 Q585T8 |
| sequenceLength | 1038 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8977320] UniProt:Q13873-1 BMPR2 [Homo sapiens] [ReferenceIsoform:8977321] UniProt:Q13873-2 BMPR2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:201442] BMPR2 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q13873 BMPR2 (50904)
