Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Diagram of DNA Damage Bypass

Class:IdPathwayDiagram:508766
_displayNameDiagram of DNA Damage Bypass
_timestamp2019-05-06 16:33:56
created[InstanceEdit:508767] Matthews, L, 2010-02-16
height1362
modified[InstanceEdit:708314] Matthews, L, 2010-05-10
[InstanceEdit:3017762] Jassal, B, 2013-02-05
[InstanceEdit:5638341] Orlic-Milacic, Marija, 2014-11-13
[InstanceEdit:5644014] Orlic-Milacic, Marija, 2014-11-19
[InstanceEdit:5652006] Orlic-Milacic, Marija, 2014-11-26
[InstanceEdit:5652011] Orlic-Milacic, Marija, 2014-11-26
[InstanceEdit:5652048] Orlic-Milacic, Marija, 2014-11-26
[InstanceEdit:5652080] Orlic-Milacic, Marija, 2014-11-26
[InstanceEdit:5652132] Orlic-Milacic, Marija, 2014-11-28
[InstanceEdit:5652139] Orlic-Milacic, Marija, 2014-11-28
[InstanceEdit:5652158] Orlic-Milacic, Marija, 2014-11-28
[InstanceEdit:5652162] Orlic-Milacic, Marija, 2014-11-28
[InstanceEdit:5652169] Orlic-Milacic, Marija, 2014-11-28
[InstanceEdit:5653641] Orlic-Milacic, Marija, 2014-12-01
[InstanceEdit:5653642] Orlic-Milacic, Marija, 2014-12-01
[InstanceEdit:5653653] Orlic-Milacic, Marija, 2014-12-01
[InstanceEdit:5653764] Orlic-Milacic, Marija, 2014-12-01
[InstanceEdit:5653775] Orlic-Milacic, Marija, 2014-12-01
[InstanceEdit:5653787] Orlic-Milacic, Marija, 2014-12-01
[InstanceEdit:5653788] Orlic-Milacic, Marija, 2014-12-02
[InstanceEdit:5653841] Orlic-Milacic, Marija, 2014-12-02
[InstanceEdit:5653898] Orlic-Milacic, Marija, 2014-12-02
[InstanceEdit:5653910] Orlic-Milacic, Marija, 2014-12-02
[InstanceEdit:5654982] Orlic-Milacic, Marija, 2014-12-04
[InstanceEdit:5654994] Orlic-Milacic, Marija, 2014-12-04
[InstanceEdit:5655147] Orlic-Milacic, Marija, 2014-12-04
[InstanceEdit:5655148] Orlic-Milacic, Marija, 2014-12-04
[InstanceEdit:5655171] Orlic-Milacic, Marija, 2014-12-04
[InstanceEdit:5655201] Orlic-Milacic, Marija, 2014-12-04
[InstanceEdit:5655465] Orlic-Milacic, Marija, 2014-12-05
[InstanceEdit:5655485] Orlic-Milacic, Marija, 2014-12-05
[InstanceEdit:5655826] Orlic-Milacic, Marija, 2014-12-09
[InstanceEdit:5655864] Orlic-Milacic, Marija, 2014-12-09
[InstanceEdit:5655918] Orlic-Milacic, Marija, 2014-12-09
[InstanceEdit:5655968] Orlic-Milacic, Marija, 2014-12-09
[InstanceEdit:5655983] Orlic-Milacic, Marija, 2014-12-09
[InstanceEdit:5656135] Orlic-Milacic, Marija, 2014-12-10
[InstanceEdit:5656138] Orlic-Milacic, Marija, 2014-12-10
[InstanceEdit:5656150] Orlic-Milacic, Marija, 2014-12-10
[InstanceEdit:5656161] Orlic-Milacic, Marija, 2014-12-10
[InstanceEdit:5656317] Orlic-Milacic, Marija, 2014-12-11
[InstanceEdit:5663021] Orlic-Milacic, Marija, 2015-01-14
[InstanceEdit:5663037] Orlic-Milacic, Marija, 2015-01-14
[InstanceEdit:5663044] Orlic-Milacic, Marija, 2015-01-14
[InstanceEdit:5663062] Orlic-Milacic, Marija, 2015-01-15
[InstanceEdit:5676170] Orlic-Milacic, Marija, 2015-02-19
[InstanceEdit:5676901] Orlic-Milacic, Marija, 2015-02-20
[InstanceEdit:5678588] Orlic-Milacic, Marija, 2015-02-24
[InstanceEdit:8986376] Orlic-Milacic, Marija, 2017-04-25
[InstanceEdit:8986403] Orlic-Milacic, Marija, 2017-04-26
[InstanceEdit:8986490] Orlic-Milacic, Marija, 2017-04-27
[InstanceEdit:9645171] Orlic-Milacic, Marija, 2019-05-06
representedPathway[Pathway:73893] DNA Damage Bypass [Homo sapiens]
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<displayName>MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2832" reactomeId="5655852" position="848 952" bounds="696 927 305 50" textPosition="697 928" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2956" reactomeId="5655912" position="848 1111" bounds="701 1086 294 51" textPosition="703 1088" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="2998" reactomeId="30555" position="802 1008" bounds="779 995 47 27" textPosition="782 998" /> <org.gk.render.RenderableChemical id="3000" reactomeId="113541" position="799 1057" bounds="779 1043 41 28" textPosition="787 1046" /> <org.gk.render.RenderableComplex id="3012" reactomeId="5655961" position="1386 1112" bounds="1269 1072 234 80" textPosition="1269 1075" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>POLK:MonoUb:K164-PCNA:RPA:RFC:(Tg:A-mispaireddNMPs)-DNA Template,(OGUA:A-mispaireddNMPs)-DNA Template,(BPDE-G:C-mispaireddNMPs)-DNA Template</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="3014" reactomeId="30555" position="1025 1056" bounds="1002 1043 47 27" textPosition="1005 1046" /> <org.gk.render.RenderableChemical id="3016" reactomeId="113541" position="1137 1036" bounds="1117 1022 41 28" textPosition="1125 1025"> <Properties> <displayName>PPi</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="3018" reactomeId="3006726" position="1174 1072" bounds="1154 1061 40 22" textPosition="1154 1061" /> <org.gk.render.RenderableComplex id="3080" reactomeId="5656114" position="765 726" bounds="664 700 202 52" textPosition="671 703" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="3081" reactomeId="5656093" position="611 734" bounds="588 715 46 38" textPosition="589 718" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>POLI:Mg2+</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="3082" reactomeId="5656097" position="835 797" bounds="714 770 242 54" textPosition="716 775" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="3278" reactomeId="5656146" position="1136 837" bounds="1067 787 138 101" textPosition="1069 797" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="3290" reactomeId="30555" position="969 841" bounds="947 828 45 26" textPosition="949 830" /> <org.gk.render.RenderableChemical id="3292" reactomeId="113541" position="1033 844" bounds="1013 830 41 28" textPosition="1021 833" /> <org.gk.render.RenderableComplex id="3407" reactomeId="5656156" position="1392 991" bounds="1282 956 220 70" textPosition="1284 963" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>POLI:MonoUb:K164-PCNA:RPA:RFC:(EtAD:T-mispaireddNMPs)-DNA Template,(Gamma-HOPdG:C-mispaireddNMPs)-DNA Template</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="3409" reactomeId="30555" position="1233 785" bounds="1210 772 47 27" textPosition="1213 775" /> <org.gk.render.RenderableChemical id="3411" reactomeId="113541" position="1329 789" bounds="1309 775 41 28" textPosition="1317 778" /> <org.gk.render.RenderableEntitySet id="3423" reactomeId="68524" position="88 484" bounds="57 473 62 22" textPosition="76 473" /> <org.gk.render.RenderableChemical id="3464" reactomeId="113518" position="1286 151" bounds="1264 136 44 30" textPosition="1269 140"> <Properties> <displayName>H2O</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="3467" reactomeId="419549" position="263 869" bounds="236 859 55 21" textPosition="238 859" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="4" reactomeId="110307" points="431 744, 431 764, 432 791" position="431 764" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="29" points="479 756" /> <Input id="436" points="431 721" /> </Inputs> <Outputs> <Output id="7" /> </Outputs> <Properties> <displayName>REV1 binds AP-dsDNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="8" reactomeId="110308" points="431 872, 431 897, 431 1032" position="431 897" lineWidth="1.0"> <Inputs> <Input id="7" points="432 838" /> <Input id="447" points="396 871" /> </Inputs> <Outputs> <Output id="9" /> </Outputs> <Catalysts> <Catalyst id="7" points="447 838, 465 859" /> </Catalysts> <Properties> <displayName>REV1 inserts dCMP opposite to AP sites in DNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="12" reactomeId="110316" points="737 598, 739 581, 741 554" position="739 581" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1666" points="689 626" /> <Input id="13" points="768 598" /> </Inputs> <Outputs> <Output id="14" /> </Outputs> <Inhibitors> <Inhibitor id="2152" points="829 655, 793 640" /> </Inhibitors> <Properties> <displayName>POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15" reactomeId="110317" points="741 465, 741 439, 740 410" position="741 439" lineWidth="1.0"> <Inputs> <Input id="1707" stoichiometry="2" points="767 466" /> <Input id="14" points="742 493" /> </Inputs> <Outputs> <Output id="16" points="740 379" /> <Output id="1739" stoichiometry="2" points="774 411" /> </Outputs> <Catalysts> <Catalyst id="14" points="727 493, 706 459" /> </Catalysts> <Properties> <displayName>Insertion of correct bases opposite the lesion by POLH</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="17" reactomeId="110319" points="741 295, 740 272, 741 242" position="740 272" lineWidth="1.0"> <Inputs> <Input id="16" points="741 315" /> <Input id="1784" points="795 289" /> </Inputs> <Outputs> <Output id="1772" points="776 216" /> <Output id="1786" points="796 239" /> </Outputs> <Catalysts> <Catalyst id="16" points="720 315, 702 293" /> </Catalysts> <Properties> <displayName>Elongation by POLH</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="70" reactomeId="5651992" points="392 220, 393 243, 393 271" position="393 243" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="71" points="392 189" /> <Input id="72" points="301 220" /> </Inputs> <Outputs> <Output id="73" /> </Outputs> <Properties> <displayName>PCNA-containing replication complex binds damaged dsDNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="134" reactomeId="5652005" points="394 336, 394 390" position="394 390" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2461" points="261 484, 261 333" /> <Input id="73" points="394 319" /> </Inputs> <Outputs> <Output id="136" /> </Outputs> <Properties> <displayName>RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="381" reactomeId="5652009" points="422 497, 434 542, 433 569" position="434 542" lineWidth="1.0"> <Inputs> <Input id="382" points="472 503" /> <Input id="136" points="405 453" /> </Inputs> <Outputs> <Output id="837" points="560 561" /> <Output id="2461" points="261 532, 261 569" /> <Output id="383" points="434 597" /> </Outputs> <Catalysts> <Catalyst id="136" points="393 453, 391 520" /> </Catalysts> <Properties> <displayName>RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="550" reactomeId="5652137" points="256 104, 255 140, 253 189" position="255 140" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="551" /> </Inputs> <Outputs> <Output id="72" /> </Outputs> <Properties> <displayName>Damaged dsDNA becomes damaged DNA template</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="552" interactionType="Activate" points="304 75, 453 77" position="378 76" lineWidth="2.0"> <Inputs> <Input id="551" /> </Inputs> <Outputs> <Output id="147" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="635" reactomeId="5652151" points="577 1103, 594 1114, 758 1201" position="594 1114" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="19" points="605 1044" /> <Input id="9" points="492 1078" /> </Inputs> <Outputs> <Output id="636" /> </Outputs> <Properties> <displayName>REV1 recruits POLZ to (AP:Cyt)-DNA Template</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="782" reactomeId="110311" points="948 1222, 1009 1221, 1037 1224" position="1009 1221" lineWidth="1.0"> <Inputs> <Input id="636" points="927 1222" /> <Input id="783" stoichiometry="10" points="937 1258" /> </Inputs> <Outputs> <Output id="784" stoichiometry="10" points="1067 1253" /> <Output id="785" points="1111 1226" /> <Output id="797" points="1142 1180" /> </Outputs> <Catalysts> <Catalyst id="636" points="882 1201, 953 1188" /> </Catalysts> <Properties> <displayName>POLZ extends translesion synthesis</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1100" reactomeId="5653756" points="1504 845, 1503 829, 1503 777" position="1503 829" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1101" points="1552 836" /> <Input id="1102" points="1502 872" /> </Inputs> <Outputs> <Output id="1103" /> </Outputs> <Properties> <displayName>TRIM25 binds monoUb:164-PCNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1194" reactomeId="5653754" points="1504 683, 1505 646, 1505 605" position="1505 646" lineWidth="1.0"> <Inputs> <Input id="1103" points="1503 720" /> <Input id="1195" stoichiometry="2" points="1462 685" /> </Inputs> <Outputs> <Output id="1197" stoichiometry="2" points="1447 602" /> <Output id="1101" points="1626 815, 1646 805, 1645 608" /> <Output id="1196" points="1502 564" /> </Outputs> <Catalysts> <Catalyst id="1103" points="1511 720, 1521 691" /> </Catalysts> <Properties> <displayName>UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1290" reactomeId="5653766" points="1500 460, 1497 441, 1499 418" position="1497 441" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1196" points="1500 505" /> <Input id="1291" points="1579 461" /> </Inputs> <Outputs> <Output id="1292" /> </Outputs> <Properties> <displayName>USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1423" reactomeId="5653770" points="1501 313, 1503 281, 1502 246" position="1503 281" lineWidth="1.0"> <Inputs> <Input id="1424" points="1487 313" /> <Input id="1292" points="1501 344" /> </Inputs> <Outputs> <Output id="1428" points="1502 212" /> <Output id="1425" points="1413 241" /> <Output id="1291" points="1607 449, 1602 326" /> <Output id="1430" points="1574 248" /> </Outputs> <Catalysts> <Catalyst id="1292" points="1520 344, 1534 323" /> </Catalysts> <Properties> <displayName>USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="1426" points="519 747, 601 699, 786 673, 1324 262" position="693 686" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="29" /> </Inputs> <Outputs> <Output id="1425" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1427" points="818 581, 1320 262" position="1069 421" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="13" /> </Inputs> <Outputs> <Output id="1425" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="1533" reactomeId="5653780" points="1507 130, 1504 112, 1469 107" position="1504 112" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1534" points="1593 93" /> <Input id="1428" points="1503 168" /> </Inputs> <Outputs> <Output id="1535" /> </Outputs> <Properties> <displayName>USP43 binds ISG:K164,ISG:K168-PCNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1556" reactomeId="5653786" points="1268 99, 1231 97, 1177 99" position="1231 97" lineWidth="1.0"> <Inputs> <Input id="3464" stoichiometry="2" points="1280 133" /> <Input id="1535" points="1310 99" /> </Inputs> <Outputs> <Output id="1559" stoichiometry="2" points="1137 141" /> <Output id="1534" points="1587 70, 1487 47, 1176 46" /> <Output id="1558" points="1123 100" /> </Outputs> <Catalysts> <Catalyst id="1535" points="1310 75, 1280 65" /> </Catalysts> <Properties> <displayName>USP43 deISGylates ISG:K164,ISG:K168-PCNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1602" reactomeId="5653838" points="682 161, 681 132, 678 92" position="681 132" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="837" points="605 542" /> <Input id="1558" points="965 115" /> </Inputs> <Outputs> <Output id="1603" /> </Outputs> <Activators> <Activator id="2427" points="588 237" /> </Activators> <Properties> <displayName>POLD,POLE binds deISGylated PCNA after TLS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1641" reactomeId="5653840" points="594 132, 564 139, 534 148" position="564 139" lineWidth="1.0"> <Inputs> <Input id="1603" points="650 92" /> <Input id="1643" points="606 143" /> </Inputs> <Outputs> <Output id="71" points="480 157" /> <Output id="551" points="304 85" /> <Output id="1645" points="544 180" /> </Outputs> <Catalysts> <Catalyst id="1603" points="630 92, 582 110" /> </Catalysts> <Properties> <displayName>POLD,POLE complete replication of damaged DNA after TLS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1869" reactomeId="5654986" points="950 221, 973 220, 1005 219" position="973 220" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1772" points="904 209" /> <Input id="1870" points="914 260" /> </Inputs> <Outputs> <Output id="1871" /> </Outputs> <Properties> <displayName>SPRTN binds monoUb:K164-PCNA associated with POLH</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1902" reactomeId="5654985" points="1088 308, 1072 314, 1032 333" position="1072 314" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1871" points="1108 252" /> <Input id="1903" points="1137 301" /> </Inputs> <Outputs> <Output id="1904" /> </Outputs> <Properties> <displayName>SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1935" reactomeId="5654989" points="970 432, 969 461, 970 508" position="969 461" lineWidth="1.0"> <Inputs> <Input id="1936" points="929 432" /> <Input id="1904" points="970 409" /> </Inputs> <Outputs> <Output id="1937" points="925 497" /> <Output id="1938" points="1013 525" /> <Output id="13" points="823 581" /> </Outputs> <Catalysts> <Catalyst id="1904" points="985 409, 1003 444" /> </Catalysts> <Properties> <displayName>SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2164" reactomeId="5655142" points="911 599, 925 605, 946 658" position="925 605" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="13" points="827 598" /> <Input id="2152" points="865 651" /> </Inputs> <Outputs> <Output id="2153" /> </Outputs> <Properties> <displayName>RCHY1 binds POLH</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2299" reactomeId="5655170" points="1027 684, 1064 688, 1095 687" position="1064 688" lineWidth="1.0"> <Inputs> <Input id="2153" points="984 680" /> <Input id="2302" stoichiometry="4" points="1033 648" /> </Inputs> <Outputs> <Output id="2300" points="1136 679" /> <Output id="2152" points="863 679, 887 712, 1074 727" /> </Outputs> <Catalysts> <Catalyst id="2153" points="984 689, 1031 708" /> </Catalysts> <Properties> <displayName>RCHY1 monoubiquitinates POLH</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2425" reactomeId="5655193" points="569 354, 571 313, 571 282" position="571 313" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2426" points="567 378" /> <Input id="2429" stoichiometry="2" points="537 349" /> </Inputs> <Outputs> <Output id="2427" /> </Outputs> <Properties> <displayName>KIAA0101 double monoubiquitination</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2655" reactomeId="5655481" points="221 716, 173 705, 165 683" position="173 705" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2657" points="221 739" /> <Input id="383" points="391 643" /> </Inputs> <Outputs> <Output id="2658" /> </Outputs> <Properties> <displayName>USP1:WDR48 binds monoUb:K164-PCNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2679" reactomeId="5655466" points="153 611, 149 569, 141 540" position="149 569" lineWidth="1.0"> <Inputs> <Input id="2658" /> </Inputs> <Outputs> <Output id="2682" points="120 379" /> <Output id="2657" points="176 753, 64 755, 68 545" /> <Output id="3423" points="98 501" /> </Outputs> <Catalysts> <Catalyst id="2658" points="171 611, 186 584" /> </Catalysts> <Properties> <displayName>USP1:WDR48 deubiquitinates monoUb:K164-PCNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2693" reactomeId="5655483" points="220 767, 217 805, 213 833" position="217 805" lineWidth="1.0"> <Inputs> <Input id="2657" /> </Inputs> <Outputs> <Output id="2694" points="191 895" /> <Output id="2695" points="165 844" /> <Output id="3467" points="248 856" /> </Outputs> <Catalysts> <Catalyst id="2657" points="232 767, 258 792" /> </Catalysts> <Properties> <displayName>USP1 autocleavage</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2829" reactomeId="5655835" points="626 929, 661 966, 693 963" position="661 966" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="29" points="525 769, 569 788" /> <Input id="2830" points="641 874" /> <Input id="2831" points="690 905" /> <Input id="19" points="612 1014" /> </Inputs> <Outputs> <Output id="2832" /> </Outputs> <Properties> <displayName>POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2955" reactomeId="5655892" points="848 1006, 847 1032, 847 1059" position="847 1032" lineWidth="1.0"> <Inputs> <Input id="2832" points="848 980" /> <Input id="2998" points="829 1006" /> </Inputs> <Outputs> <Output id="2956" points="847 1083" /> <Output id="3000" points="823 1057" /> </Outputs> <Catalysts> <Catalyst id="2832" points="861 980, 882 1015" /> </Catalysts> <Properties> <displayName>POLK incorporates dNMP opposite to damaged DNA base</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3011" reactomeId="5655965" points="1040 1113, 1085 1112, 1119 1111" position="1085 1112" lineWidth="1.0"> <Inputs> <Input id="2956" points="998 1112" /> <Input id="3014" stoichiometry="10" points="1028 1073" /> </Inputs> <Outputs> <Output id="3012" points="1266 1111" /> <Output id="3016" stoichiometry="10" points="1133 1053" /> <Output id="3018" points="1158 1086" /> <Output id="797" points="1163 1150" /> </Outputs> <Catalysts> <Catalyst id="2956" points="998 1134, 1026 1139" /> </Catalysts> <Properties> <displayName>POLK and POLZ cooperate in elongation of mispaired primer termini</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3079" reactomeId="5656105" points="612 771, 637 788, 711 791" position="637 788" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="29" points="525 762" /> <Input id="3080" points="676 755" /> <Input id="19" points="611 1014" /> <Input id="3081" points="611 756" /> </Inputs> <Outputs> <Output id="3082" /> </Outputs> <Properties> <displayName>POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3277" reactomeId="5656148" points="981 799, 1001 799, 1017 802" position="1001 799" lineWidth="1.0"> <Inputs> <Input id="3082" points="959 798" /> <Input id="3290" points="972 825" /> </Inputs> <Outputs> <Output id="3278" points="1064 816" /> <Output id="3292" points="1027 827" /> </Outputs> <Catalysts> <Catalyst id="3082" points="939 767, 982 759" /> </Catalysts> <Properties> <displayName>POLI incorporates dNMP opposite to damaged DNA base</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3406" reactomeId="5656158" points="1235 842, 1261 843, 1292 842" position="1261 843" lineWidth="1.0"> <Inputs> <Input id="3278" points="1208 840" /> <Input id="3409" stoichiometry="10" points="1233 802" /> </Inputs> <Outputs> <Output id="3407" points="1368 953" /> <Output id="797" points="1182 1150" /> <Output id="3018" points="1179 1058" /> <Output id="3411" stoichiometry="10" points="1319 806" /> </Outputs> <Catalysts> <Catalyst id="3278" points="1208 870, 1234 884" /> </Catalysts> <Properties> <displayName>POLZ elongates POLI-incorporated dNMP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3465" reactomeId="110322" points="555 962, 571 973, 602 1014" position="571 973" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="28" points="531 960" /> <Input id="27" points="557 936" /> </Inputs> <Outputs> <Output id="19" /> </Outputs> <Properties> <displayName>Formation of Pol zeta complex</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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