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Details on Person UniProt:O75800 ZMYND10
| Class:Id | ReferenceGeneProduct:50866 |
|---|---|
| _chainChangeLog | chain:1-440 added on Fri February 6 2015 |
| _displayName | UniProt:O75800 ZMYND10 |
| _timestamp | 2024-11-03 20:17:35 |
| chain | chain:1-440 |
| checksum | 510D41074C956CA3 |
| comment | FUNCTION Plays a role in axonemal structure organization and motility (PubMed:23891469, PubMed:23891471). Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility (By similarity). May act by indirectly regulating transcription of dynein proteins (By similarity).SUBUNIT Interacts (via C-terminus) with DNAAF11 (via CS domain); this interaction stabilizes DNAAF11 at the protein level (PubMed:23891469, PubMed:23891471, PubMed:29601588). Interacts (via C-terminus) with DNAL1; this interaction stabilizes DNAL1 at the protein level (PubMed:29601588). Interacts with DNAAF4, HSPA8, IQUB, RUVBL2 and DYNTL5 (PubMed:29601588).INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the ZMYND10 family. |
| description | recommendedName: fullName evidence="12"Zinc finger MYND domain-containing protein 10 alternativeName: fullName evidence="11"Protein BLu |
| geneName | ZMYND10 BLU LUCA12.4 |
| identifier | O75800 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Ciliopathy Cytoplasm Cytoskeleton Disease variant Kartagener syndrome Membrane Metal-binding Primary ciliary dyskinesia Proteomics identification Reference proteome Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ZMYND10 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998109] ENSEMBL:ENSG00000004838 ZMYND10 [Homo sapiens] |
| secondaryIdentifier | ZMY10_HUMAN A6NK41 B3KU54 O14570 O75801 Q53FE6 Q8N4R6 Q8NDN6 |
| sequenceLength | 440 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:156380] UniProt:O75800-2 ZMYND10 [Homo sapiens] [ReferenceIsoform:401892] UniProt:O75800-1 ZMYND10 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9969501] ZMYND10 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O75800 ZMYND10 (50866)
