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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person Diagram of RNA Polymerase II Transcription

Class:IdPathwayDiagram:508525
_displayNameDiagram of RNA Polymerase II Transcription
_timestamp2026-03-05 23:09:02
created[InstanceEdit:508526] Gillespie, ME, 2010-02-12
height1308
modified[InstanceEdit:1679954] Wu, G, 2011-10-20
[InstanceEdit:1880368] Rothfels, K, 2011-10-31
[InstanceEdit:1881846] Rothfels, K, 2011-10-31
[InstanceEdit:3045610] Jassal, B, 2013-02-06
[InstanceEdit:5652052] Gillespie, Marc E, 2014-11-26
[InstanceEdit:6807468] May, Bruce, 2015-11-02
[InstanceEdit:8855180] Wu, G, 2016-02-02
[InstanceEdit:8866700] May, Bruce, 2016-04-03
[InstanceEdit:8867811] May, Bruce, 2016-04-18
[InstanceEdit:8932795] May, Bruce, 2016-07-29
[InstanceEdit:8932799] May, Bruce, 2016-07-29
[InstanceEdit:8932916] May, Bruce, 2016-07-31
[InstanceEdit:8932917] May, Bruce, 2016-07-31
[InstanceEdit:8932921] May, Bruce, 2016-07-31
[InstanceEdit:8939955] Jupe, Steve, 2016-09-22
[InstanceEdit:8953809] D'Eustachio, Peter, 2016-12-28
[InstanceEdit:8953810] D'Eustachio, Peter, 2016-12-28
[InstanceEdit:9613504] Gillespie, Marc E, 2018-07-13
[InstanceEdit:9615483] May, Bruce, 2018-08-07
[InstanceEdit:9616910] D'Eustachio, Peter, 2018-08-15
[InstanceEdit:9616914] D'Eustachio, Peter, 2018-08-15
[InstanceEdit:9645116] Wu, G, 2019-05-03
[InstanceEdit:9757681] D'Eustachio, Peter, 2021-11-03
[InstanceEdit:9757682] D'Eustachio, Peter, 2021-11-03
[InstanceEdit:9774100] Matthews, Lisa, 2022-05-16
[InstanceEdit:9827779] May, Bruce, 2023-02-04
[InstanceEdit:9984275] Orlic-Milacic, Marija, 2026-03-05
[InstanceEdit:9984276] Orlic-Milacic, Marija, 2026-03-05
representedPathway[Pathway:73857] RNA Polymerase II Transcription [Homo sapiens]
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<displayName>Addition of Nucleotides 5 through 9 on the growing Transcript</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="55" reactomeId="76576" points="546 842, 516 842, 485 841" position="516 842" lineWidth="1.0"> <Inputs> <Input id="50" points="596 843" /> <Input id="1141" stoichiometry="2" points="568 890" /> </Inputs> <Outputs> <Output id="56" points="452 840" /> <Output id="60" stoichiometry="2" points="476 890" /> </Outputs> <Catalysts> <Catalyst id="10" points="814 660, 516 801" /> </Catalysts> <Properties> <displayName>Addition of nucleotides 10 and 11 on the growing transcript: Third Transition</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="61" reactomeId="111264" points="274 838, 236 838, 183 838" position="236 838" lineWidth="1.0"> <Inputs> <Input id="1139" points="299 890" /> <Input id="56" points="312 838" /> </Inputs> <Outputs> <Output id="62" points="157 881" /> <Output id="64" points="161 815" /> </Outputs> <Catalysts> <Catalyst id="10" points="801 647, 235 787" /> </Catalysts> <Properties> <displayName>Addition of nucleotides between position +11 and +30</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="79" reactomeId="113430" points="144 937, 145 1005, 144 1063" position="145 1005" lineWidth="1.0"> <Inputs> <Input id="62" /> </Inputs> <Outputs> <Output id="80" /> </Outputs> <Properties> <displayName>Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="82" reactomeId="77071" points="243 1117, 260 1099, 276 1117" position="260 1099" lineWidth="1.0"> <Inputs> <Input id="80" points="214 1110" /> <Input id="1606" stoichiometry="13" points="216 1156" /> </Inputs> <Outputs> <Output id="83" points="312 1110" /> <Output id="1607" stoichiometry="13" points="294 1155" /> </Outputs> <Catalysts> <Catalyst id="80" points="214 1081, 259 1069" /> </Catalysts> <Properties> <displayName>Phosphorylation (Ser5) of RNA pol II CTD</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="86" reactomeId="77069" points="488 1131, 509 1131, 548 1131" position="509 1131" lineWidth="1.0"> <Inputs> <Input id="87" points="413 1199" /> <Input id="83" points="453 1119" /> </Inputs> <Outputs> <Output id="88" /> </Outputs> <Properties> <displayName>RNA Polymerase II CTD (phosphorylated) binds to CE</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="89" reactomeId="77068" points="666 1130, 688 1130, 714 1130" position="688 1130" lineWidth="1.0"> <Inputs> <Input id="88" /> </Inputs> <Outputs> <Output id="90" /> </Outputs> <Properties> <displayName>Activation of GT</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="91" reactomeId="77073" points="870 1127, 894 1127, 925 1127" position="894 1127" lineWidth="1.0"> <Inputs> <Input id="592" points="830 1222" /> <Input id="90" points="836 1128" /> <Input id="93" points="829 1078" /> </Inputs> <Outputs> <Output id="94" /> </Outputs> <Properties> <displayName>SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="95" reactomeId="112383" points="1298 987, 1337 986, 1359 987" position="1337 986" lineWidth="1.0"> <Inputs> <Input id="96" points="1310 941" /> <Input id="97" points="1271 996" /> <Input id="70" points="1205 945" /> </Inputs> <Outputs> <Output id="98" points="1393 1187" /> <Output id="68" points="1394 932" /> </Outputs> <Catalysts> <Catalyst id="96" points="1322 941, 1335 955" /> </Catalysts> <Properties> <displayName>Hypophosphorylation of RNA Pol II CTD by FCP1P protein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="99" reactomeId="113407" points="1491 1224, 1522 1223, 1557 1224" position="1522 1223" lineWidth="1.0"> <Inputs> <Input id="98" points="1472 1223" /> <Input id="100" points="1587 998" /> </Inputs> <Outputs> <Output id="101" /> </Outputs> <Properties> <displayName>DSIF complex binds to RNA Pol II (hypophosphorylated)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="103" reactomeId="113402" points="1766 1225, 1812 1225, 1853 1226" position="1812 1225" lineWidth="1.0"> <Inputs> <Input id="101" points="1697 1225" /> <Input id="104" points="1763 1112" /> <Input id="1262" points="1793 1184" /> </Inputs> <Outputs> <Output id="105" points="1914 1166" /> <Output id="1262" points="1815 1184" /> </Outputs> <Properties> <displayName>Formation of DSIF:NELF:early elongation complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="108" reactomeId="112381" points="2034 1086, 2046 1113, 2170 1161" position="2046 1113" lineWidth="1.0"> <Inputs> <Input id="672" points="1784 984" /> <Input id="105" points="1963 1124" /> <Input id="718" points="2034 989" /> <Input id="109" points="2112 990" /> <Input id="670" points="1888 990" /> <Input id="669" points="1840 985" /> <Input id="671" points="1940 990" /> <Input id="117" points="1984 989" /> <Input id="1508" stoichiometry="11" points="1908 1062" /> </Inputs> <Outputs> <Output id="111" points="2409 1183" /> <Output id="1509" stoichiometry="11" points="2187 1204" /> <Output id="110" points="2459 1241" /> </Outputs> <Catalysts> <Catalyst id="109" points="2115 990" /> </Catalysts> <Properties> <displayName>Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="113" reactomeId="112379" points="2522 854, 2518 743, 2435 667" position="2518 743" lineWidth="1.0"> <Inputs> <Input id="116" points="2247 918" /> <Input id="111" points="2522 1169" /> <Input id="114" points="2231 765" /> <Input id="115" points="2225 831" /> <Input id="708" points="2230 893" /> <Input id="646" points="2219 800" /> <Input id="709" points="2219 861" /> <Input id="714" points="2444 772" /> </Inputs> <Outputs> <Output id="118" /> </Outputs> <Properties> <displayName>Recruitment of elongation factors to form elongation complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="121" reactomeId="112385" points="2358 607, 2355 574, 2355 548" position="2355 574" lineWidth="1.0"> <Inputs> <Input id="118" points="2384 622" /> <Input id="1338" points="2332 623" /> </Inputs> <Outputs> <Output id="122" points="2287 516" /> <Output id="120" points="2394 513" /> </Outputs> <Properties> <displayName>Addition of nucleotides leads to transcript elongation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="124" reactomeId="113412" points="2260 448, 2259 409, 2258 363" position="2259 409" lineWidth="1.0"> <Inputs> <Input id="122" points="2262 484" /> <Input id="1377" points="2211 413" /> </Inputs> <Outputs> <Output id="125" points="2181 339" /> <Output id="1377" points="2211 389" /> </Outputs> <Properties> <displayName>Pol II elongation complex moves on the template as transcript elongates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="134" reactomeId="112396" points="2130 297, 2130 269, 2130 222" position="2130 269" lineWidth="1.0"> <Inputs> <Input id="125" /> </Inputs> <Outputs> <Output id="135" /> </Outputs> <Properties> <displayName>Separation of elongating transcript from template</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="144" reactomeId="77592" points="2640 498, 2661 498, 2697 498" position="2661 498" lineWidth="1.0"> <Inputs> <Input id="145" /> </Inputs> <Outputs> <Output id="139" points="2678 437" /> <Output id="140" points="2727 438" /> <Output id="142" points="2774 437" /> <Output id="146" points="2755 493" /> <Output id="147" points="2739 524" /> </Outputs> <Properties> <displayName>Cleavage of Intronless Pre-mRNA at 3'-end</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="148" reactomeId="77586" points="2625 644, 2657 645, 2683 645" position="2657 645" lineWidth="1.0"> <Inputs> <Input id="149" /> </Inputs> <Outputs> <Output id="150" points="2711 638" /> <Output id="151" points="2740 678" /> </Outputs> <Properties> <displayName>Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="152" reactomeId="111437" points="2693 745, 2716 745, 2756 744" position="2716 745" lineWidth="1.0"> <Inputs> <Input id="153" /> </Inputs> <Outputs> <Output id="154" points="2777 773" /> <Output id="151" points="2761 713" /> </Outputs> <Properties> <displayName>Cleavage of the 3'-end of the Histone Pre-mRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="155" reactomeId="73946" points="1752 727, 1958 724, 1941 369, 1840 368, 1018 366" position="1840 368" lineWidth="1.0"> <Inputs> <Input id="34" /> </Inputs> <Outputs> <Output id="16" points="1105 438" /> <Output id="10" points="880 604" /> <Output id="156" points="1090 320" /> <Output id="13" points="917 438" /> <Output id="3" points="165 458" /> <Output id="7" points="563 467" /> <Output id="6" points="477 449" /> </Outputs> <Properties> <displayName>Abortive initiation after formation of the first phosphodiester bond</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="161" reactomeId="75891" points="799 312, 843 312, 844 359" position="843 312" lineWidth="1.0"> <Inputs> <Input id="162" /> </Inputs> <Outputs> <Output id="16" points="1092 443" /> <Output id="10" points="863 604" /> <Output id="13" points="896 438" /> <Output id="163" points="951 259" /> </Outputs> <Properties> <displayName>Abortive Initiation After Second Transition</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="164" reactomeId="75856" points="523 298, 553 300, 552 349" position="553 300" lineWidth="1.0"> <Inputs> <Input id="165" /> </Inputs> <Outputs> <Output id="16" points="1092 446" /> <Output id="10" points="861 604, 836 455" /> <Output id="13" points="882 446" /> <Output id="166" points="689 231" /> <Output id="3" points="165 455" /> <Output id="7" points="542 458" /> <Output id="6" points="460 439" /> </Outputs> <Properties> <displayName>Abortive Initiation Before Second Transition</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="167" reactomeId="112434" points="1483 984, 1508 983, 1544 983" position="1508 983" lineWidth="1.0"> <Inputs> <Input id="592" points="854 1222" /> <Input id="168" points="1466 971" /> </Inputs> <Outputs> <Output id="100" /> </Outputs> <Properties> <displayName>Formation of DSIF complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="169" reactomeId="112435" points="2428 1046, 2429 1020, 2428 976" position="2429 1020" lineWidth="1.0" reactionType="Transition"> <Inputs> <Input id="170" points="2417 1061" /> <Input id="171" points="2454 1059" /> </Inputs> <Outputs> <Output id="172" /> </Outputs> <Properties> <displayName>Formation of Elongin BC complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="173" reactomeId="112429" points="2196 697, 2197 714, 2197 737" position="2197 714" lineWidth="1.0"> <Inputs> <Input id="174" points="2177 686" /> <Input id="175" points="2217 686" /> </Inputs> <Outputs> <Output id="114" /> </Outputs> <Properties> <displayName>Formation of FACT complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="176" reactomeId="112437" points="1664 1096, 1685 1096, 1713 1096" position="1685 1096" lineWidth="1.0"> <Inputs> <Input id="177" points="1640 1090" /> <Input id="178" points="1643 1055" /> <Input id="179" points="1650 1123" /> <Input id="180" points="1645 1100" /> </Inputs> <Outputs> <Output id="104" /> </Outputs> <Properties> <displayName>Formation of NELF complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="181" reactomeId="112430" points="2125 1047, 2124 1023, 2122 990" position="2124 1023" lineWidth="1.0" reactionType="Transition"> <Inputs> <Input id="184" points="2114 1062" /> <Input id="632" points="2135 1058" /> </Inputs> <Outputs> <Output id="109" /> </Outputs> <Properties> <displayName>Formation of P-TEFb complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="185" reactomeId="112436" points="2344 931, 2312 931, 2262 931" position="2312 931" lineWidth="1.0" reactionType="Transition"> <Inputs> <Input id="172" points="2395 947" /> <Input id="1459" points="2385 924" /> </Inputs> <Outputs> <Output id="116" /> </Outputs> <Properties> <displayName>Formation of Elongin complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="187" reactomeId="112392" points="2090 480, 2145 461, 2223 484" position="2145 461" lineWidth="1.0"> <Inputs> <Input id="188" /> </Inputs> <Outputs> <Output id="122" /> </Outputs> <Properties> <displayName>Resumption of elongation after recovery from pausing</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="189" reactomeId="113411" points="2223 516, 2139 541, 2087 522" position="2139 541" lineWidth="1.0"> <Inputs> <Input id="122" /> </Inputs> <Outputs> <Output id="188" /> </Outputs> <Properties> <displayName>2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="190" reactomeId="113414" points="2273 484, 2343 405, 2411 261" position="2343 405" lineWidth="1.0"> <Inputs> <Input id="122" /> </Inputs> <Outputs> <Output id="191" /> </Outputs> <Properties> <displayName>7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="196" reactomeId="113413" points="2407 261, 2315 396, 2269 484" position="2315 396" lineWidth="1.0"> <Inputs> <Input id="191" /> </Inputs> <Outputs> <Output id="122" /> </Outputs> <Properties> <displayName>TFIIS-mediated recovery of elongation from arrest</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="459" reactomeId="113409" points="1931 1166, 1931 1198, 1931 1233" position="1931 1198" lineWidth="1.0"> <Inputs> <Input id="105" /> </Inputs> <Outputs> <Output id="460" /> </Outputs> <Properties> <displayName>Abortive termination of early transcription elongation by DSIF:NELF</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="469" reactomeId="112395" points="2500 240, 2533 241, 2568 240" position="2533 241" lineWidth="1.0"> <Inputs> <Input id="191" /> </Inputs> <Outputs> <Output id="470" /> </Outputs> <Properties> <displayName>Abortive termination of elongation after arrest</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="591" reactomeId="75862" points="1487 545, 1459 601, 1372 602, 1283 601, 1258 537" position="1372 602" lineWidth="1.0"> <Inputs> <Input id="24" /> </Inputs> <Outputs> <Output id="17" /> </Outputs> <Properties> <displayName>Fall Back to Closed Pre-initiation Complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="629" reactomeId="5652025" points="2295 1106, 2250 1060, 2211 1019" position="2250 1060" lineWidth="1.0" reactionType="Transition"> <Inputs> <Input id="630" /> </Inputs> <Outputs> <Output id="631" points="2252 996" /> <Output id="109" points="2146 990" /> </Outputs> <Properties> <displayName>P-TEFb disassociates from the 7SK snRNP Complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="725" reactomeId="113429" points="2251 516, 2115 668, 1988 861" position="2115 668" lineWidth="1.0"> <Inputs> <Input id="122" /> </Inputs> <Outputs> <Output id="708" points="2160 892" /> <Output id="117" points="1979 959" /> <Output id="104" points="1757 1084, 1700 965" /> <Output id="718" points="2029 959" /> <Output id="709" points="2168 861" /> <Output id="672" points="1775 961" /> <Output id="115" points="2167 833" /> <Output id="727" points="1707 856" /> <Output id="100" points="1627 970" /> <Output id="728" points="1897 811" /> <Output id="646" points="2166 803" /> <Output id="671" points="1935 959" /> <Output id="669" points="1831 960" /> <Output id="670" points="1883 959" /> <Output id="109" points="2107 959" /> <Output id="726" points="1787 812" /> <Output id="114" points="2176 765" /> <Output id="116" points="2169 918" /> <Output id="1021" points="1688 913" /> <Output id="1223" points="1954 813" /> </Outputs> <Properties> <displayName>Elongating transcript encounters a lesion in the template</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="950" reactomeId="9613497" points="1656 671, 1678 648, 1712 671" position="1678 648" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="34" points="1676 707" /> <Input id="1416" points="1610 626" /> </Inputs> <Outputs> <Output id="34" points="1694 707" /> <Output id="33" points="1749 650" /> </Outputs> <Catalysts> <Catalyst id="986" points="1658 588" /> </Catalysts> <Properties> <displayName>Unwinding DNA for the nascent transcript</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="951" reactomeId="9613494" points="1280 842, 1312 854, 1344 841" position="1312 854" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="1064" points="1261 866" /> <Input id="36" points="1288 798" /> </Inputs> <Outputs> <Output id="1063" points="1379 848" /> <Output id="36" points="1315 798" /> <Output id="38" points="1384 815" /> </Outputs> <Catalysts> <Catalyst id="68" points="1382 899" /> </Catalysts> <Properties> <displayName>Unwinding of DNA for the Nascent Transcript: Second Transition</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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