Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person Diagram of DNA Replication Pre-Initiation

Class:IdPathwayDiagram:508493
_displayNameDiagram of DNA Replication Pre-Initiation
_timestamp2021-11-21 12:47:57
created[InstanceEdit:508492] Matthews, L, 2010-02-12
height1544
modified[InstanceEdit:593701] D'Eustachio, P, 2010-04-13
[InstanceEdit:692066] Matthews, L, 2010-05-07
[InstanceEdit:1359764] Wu, G, 2011-06-02
[InstanceEdit:1547414] D'Eustachio, P, 2011-08-27
[InstanceEdit:1638113] Orlic-Milacic, M, 2011-10-07
[InstanceEdit:1638135] Orlic-Milacic, M, 2011-10-07
[InstanceEdit:1671732] Orlic-Milacic, M, 2011-10-17
[InstanceEdit:1676220] Orlic-Milacic, M, 2011-10-17
[InstanceEdit:2214353] Orlic-Milacic, M, 2012-04-30
[InstanceEdit:2426702] Orlic-Milacic, M, 2012-08-08
[InstanceEdit:2555397] Orlic-Milacic, M, 2012-11-02
[InstanceEdit:2558339] Orlic-Milacic, M, 2012-11-02
[InstanceEdit:2580343] Orlic-Milacic, M, 2012-11-12
[InstanceEdit:3061402] Jupe, S, 2013-02-06
[InstanceEdit:9036293] D'Eustachio, Peter, 2018-01-31
[InstanceEdit:9611138] Matthews, Lisa, 2018-06-15
[InstanceEdit:9611139] Matthews, Lisa, 2018-06-15
[InstanceEdit:9750781] Orlic-Milacic, Marija, 2021-08-16
[InstanceEdit:9750784] Orlic-Milacic, Marija, 2021-08-16
[InstanceEdit:9750798] Orlic-Milacic, Marija, 2021-08-16
[InstanceEdit:9757418] Orlic-Milacic, Marija, 2021-10-30
[InstanceEdit:9757419] Orlic-Milacic, Marija, 2021-10-30
[InstanceEdit:9757421] Orlic-Milacic, Marija, 2021-10-30
[InstanceEdit:9757465] Orlic-Milacic, Marija, 2021-11-01
[InstanceEdit:9757614] Orlic-Milacic, Marija, 2021-11-02
[InstanceEdit:9757629] Orlic-Milacic, Marija, 2021-11-03
[InstanceEdit:9757641] Orlic-Milacic, Marija, 2021-11-03
[InstanceEdit:9757723] Orlic-Milacic, Marija, 2021-11-04
[InstanceEdit:9757726] Orlic-Milacic, Marija, 2021-11-04
[InstanceEdit:9758623] Orlic-Milacic, Marija, 2021-11-19
[InstanceEdit:9758635] Matthews, Lisa, 2021-11-21
representedPathway[Pathway:69002] DNA Replication Pre-Initiation [Homo sapiens]
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169" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="697" points="404 167" /> <Input id="705" points="404 204" /> </Inputs> <Outputs> <Output id="706" points="539 217" /> <Output id="707" points="557 169" /> </Outputs> <Properties> <displayName>ORC6 is phosphorylated on T195</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="726" reactomeId="9734713" points="687 168, 835 165, 898 168" position="835 165" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="707" /> </Inputs> <Outputs> <Output id="727" points="1005 139" /> <Output id="728" points="1004 193" /> </Outputs> <Properties> <displayName>ORC6 translocates to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="741" reactomeId="9734730" points="681 272, 833 277, 1451 345" position="833 277" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="742" /> </Inputs> <Outputs> <Output id="461" /> </Outputs> <Properties> <displayName>ORC1 translocates to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="763" reactomeId="9749098" points="1493 276, 1538 275, 1588 275" position="1538 275" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="764" points="1448 231" /> <Input id="461" points="1483 335" /> </Inputs> <Outputs> <Output id="765" /> </Outputs> <Activators> <Activator id="766" points="1533 167" /> </Activators> <Properties> <displayName>ORC1 binds to DNA at origin of replication sites</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="785" reactomeId="9749197" points="1363 256, 1362 147, 1468 146" position="1362 147" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="786" points="1288 256" /> <Input id="461" points="1467 335" /> </Inputs> <Outputs> <Output id="766" /> </Outputs> <Properties> <displayName>ORC1 binds to H4K20me2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="924" reactomeId="68712" points="1542 918, 1443 913, 1364 913" position="1443 913" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="687" points="1559 950" /> <Input id="925" stoichiometry="3" points="1556 878" /> </Inputs> <Outputs> <Output id="487" points="1341 803" /> <Output id="926" points="1330 979" /> </Outputs> <Catalysts> <Catalyst id="927" points="1443 980" /> </Catalysts> <Properties> <displayName>The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="928" reactomeId="68825" points="1322 1016, 1321 1073, 1322 1147" position="1321 1073" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="926" /> </Inputs> <Outputs> <Output id="931" stoichiometry="3" /> </Outputs> <Catalysts> <Catalyst id="929" points="1249 1073" /> </Catalysts> <Properties> <displayName>Ubiquitinated geminin is degraded by the proteasome</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="944" interactionType="Activate" points="2132 254, 2150 344" position="2141 299" lineWidth="2.0"> <Inputs> <Input id="933" /> </Inputs> <Outputs> <Output id="475" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="945" reactomeId="9749215" points="2182 404, 2165 427, 2123 478" position="2165 427" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="475" points="2159 372" /> <Input id="946" points="2230 362" /> </Inputs> <Outputs> <Output id="943" /> </Outputs> <Properties> <displayName>MCM8 binds CDC6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="947" reactomeId="9757256" points="1779 909, 1830 906, 1895 909" position="1830 906" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="948" points="1731 890" /> <Input id="949" points="1738 927" /> </Inputs> <Outputs> <Output id="950" /> </Outputs> <Properties> <displayName>MCM3 binds MCM5</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="951" reactomeId="9757257" points="1843 1052, 1897 1053, 1968 1050" position="1897 1053" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="952" points="1748 1060" /> <Input id="953" points="1756 1015" /> <Input id="954" points="1752 1110" /> </Inputs> <Outputs> <Output id="955" /> </Outputs> <Properties> <displayName>MCM4, MCM6 and MCM7 form a heterotrimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="956" reactomeId="9757258" points="2038 919, 2031 874, 2004 818" position="2031 874" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="955" points="2033 1034" /> <Input id="957" points="2141 1012" /> </Inputs> <Outputs> <Output id="958" /> </Outputs> <Properties> <displayName>MCM2 binds MCM4:MCM6:MCM7 heterotrimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="959" reactomeId="9749253" points="1846 833, 1791 818, 1714 796" position="1791 818" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="950" points="1926 897" /> <Input id="958" points="1930 812" /> </Inputs> <Outputs> <Output id="491" /> </Outputs> <Properties> <displayName>Formation of MCM2-7 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="960" reactomeId="9749286" points="1480 777, 1481 713, 1481 662" position="1481 713" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="487" points="1365 786" /> <Input id="491" points="1649 786" /> </Inputs> <Outputs> <Output id="961" /> </Outputs> <Properties> <displayName>CDT1 binds MCM2-7</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="969" reactomeId="9749320" points="1776 571, 1711 558, 1560 542" position="1711 558" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="961" points="1521 635" /> <Input id="942" points="1953 569" /> </Inputs> <Outputs> <Output id="970" /> </Outputs> <Properties> <displayName>CDT1-mediated loading of MCM2-7 to replication origins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="971" reactomeId="9749350" points="1369 526, 1315 525, 1279 522" position="1315 525" lineWidth="1.0"> <Inputs> <Input id="972" points="1383 565" /> <Input id="970" points="1425 530" /> </Inputs> <Outputs> <Output id="487" points="1330 803, 1174 1024, 886 1026, 904 525, 1257 467" /> <Output id="973" points="1251 521" /> <Output id="974" points="1256 571" /> </Outputs> <Catalysts> <Catalyst id="970" points="1425 511, 1350 483" /> </Catalysts> <Properties> <displayName>ATP-dependent release of CDT1 from the OCCM complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="975" reactomeId="9749351" points="1167 636, 1145 683, 1130 717" position="1145 683" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="961" points="1426 646" /> <Input id="973" points="1175 544" /> </Inputs> <Outputs> <Output id="487" points="1314 780" /> <Output id="976" points="1100 774" /> </Outputs> <Properties> <displayName>CDT1-mediated formation of MCM2-7 double hexamer at the replication origin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="977" interactionType="Activate" points="1089 818, 1082 886" position="1085 852" lineWidth="2.0"> <Inputs> <Input id="976" /> </Inputs> <Outputs> <Output id="932" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="978" reactomeId="68688" points="2022 432, 2019 486, 2020 548" position="2019 486" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="902" points="2019 385" /> <Input id="475" points="2133 372" /> </Inputs> <Outputs> <Output id="942" /> </Outputs> <Activators> <Activator id="943" points="2072 489" /> </Activators> <Properties> <displayName>CDC6 association with ORC(1-6) at replication origins</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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