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Details on Person alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+

Class:IdReaction:508369
_displayNamealpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+
_doReleaseTRUE
_timestamp2024-10-28 22:29:22
authored[InstanceEdit:517475] D'Eustachio, P, 2010-02-18
catalystActivity[CatalystActivity:70835] (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity of HSD17B10 tetramer [mitochondrial matrix]
catalystActivityReference[CatalystActivityReference:9643191] 3-hydroxyacyl-CoA dehydrogenase activity of HSD17B10 tetramer [mitochondrial matrix] 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency Is caused by mutations in the HADH2 gene
compartment[Compartment:5460] mitochondrial matrix
created[InstanceEdit:508376] D'Eustachio, P, 2010-02-11
crossReference[DatabaseIdentifier:9917118] RHEA:13283
input[SimpleEntity:70836] 2MACA-CoA [mitochondrial matrix]
[SimpleEntity:29362] NADH [mitochondrial matrix]
[SimpleEntity:113529] H+ [mitochondrial matrix]
isChimericFALSE
literatureReference[LiteratureReference:508368] Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeutics
[LiteratureReference:70832] 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency Is caused by mutations in the HADH2 gene
modified[InstanceEdit:508390] D'Eustachio, P, 2010-02-11
[InstanceEdit:517476] D'Eustachio, P, 2010-02-18
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9908873] Stephan, Ralf, 2024-04-23
[InstanceEdit:9917131] Stephan, Ralf, 2024-07-30
[InstanceEdit:9925948] D'Eustachio, Peter, 2024-10-28
namealpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+
2-methyl-3-oxobutanoyl-CoA + H(+) + NADH => (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+)
negativePrecedingEvent[NegativePrecedingEvent:9908875] Futile Cycle: alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+
output[SimpleEntity:70829] aMbHBUT-CoA [mitochondrial matrix]
[SimpleEntity:113526] NAD+ [mitochondrial matrix]
releaseDate2010-03-16
reverseReaction
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1104176] R-HSA-508369.7
summation[Summation:508377] Mitochondrial 3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B...
(hasEvent)[Pathway:70895] Branched-chain amino acid catabolism [Homo sapiens]
(precedingEvent)[NegativePrecedingEvent:9908868] Futile Cycle: alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+
(reverseReaction)[Reaction:70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ [Homo sapiens]
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