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Details on Person Combination of chromatin immunoprecipitation (ChIP) microarr...

Class:IdSummation:5083672
_displayNameCombination of chromatin immunoprecipitation (ChIP) microarr...
_timestamp2014-07-07 13:06:45
created[InstanceEdit:5083642] Shamovsky, V, 2013-11-07
literatureReference[LiteratureReference:4793785] Genome-wide analysis of human HSF1 signaling reveals a transcriptional program linked to cellular adaptation and survival
[LiteratureReference:5096428] Transcriptional response to stress in the dynamic chromatin environment of cycling and mitotic cells
[LiteratureReference:4793724] Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells
[LiteratureReference:4793807] The role of heat shock transcription factor 1 in the genome-wide regulation of the mammalian heat shock response
[LiteratureReference:4793833] Transcriptional regulation and binding of heat shock factor 1 and heat shock factor 2 to 32 human heat shock genes during thermal stress and differentiation
[LiteratureReference:5606269] Human Elongator facilitates RNA polymerase II transcription through chromatin
[LiteratureReference:5606273] hELP3 subunit of the Elongator complex regulates the transcription of HSP70 gene in human cells
[LiteratureReference:5096340] hElp3 directly modulates the expression of HSP70 gene in HeLa cells via HAT activity
modified[InstanceEdit:5096432] Shamovsky, V, 2013-11-09
[InstanceEdit:5606278] Shamovsky, V, 2014-07-07
textCombination of chromatin immunoprecipitation (ChIP) microarray analysis and time course gene expression microarray analysis with and without siRNA-mediated inhibition of HSF1 showed that human HSF1 can induce the expression of different sets of target genes to maintain a wide range of biological processes (e.g., anti-apoptosis, RNA splicing, ubiquitination)(Page TG et al. 2006; Vihervaara A. et al. 2013). However, HSF1 is best known for rapid stress-induced upregulation of certain genes related to protein folding, such as HSPA1A/HSP70, HSPC/HSP90, HSPB1/HSP27, and DNAJB1/HSP40 (Mosser DD et al. 1988; Trinklein ND et al. 2004a,b; Page TG et al. 2006; Vihervaara A. et al. 2013).

In the nucleus acetylation of Histone H3 is linked to the function of the Elongator complex in transcription (Kim JH et al. 2002). Elongator complex protein 3 (ELP3), a catalytic acetyltransferase subunit of the Elongator complex, has been reported to regulate the transcription of HSP70 gene, and the histone acetyltransferase (HAT) domain of ELP3 is essential for this function (Han Q et al. 2007; Li F et al. 2001).

(summation)[BlackBoxEvent:5082356] HSF1-mediated gene expression [Homo sapiens]
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