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Details on Person UniProt:Q3TN34 Micall2
| Class:Id | ReferenceGeneProduct:5083176 |
|---|---|
| _chainChangeLog | chain:1-1009 added on Sat February 7 2015 |
| _displayName | UniProt:Q3TN34 Micall2 |
| _timestamp | 2025-02-21 20:11:29 |
| chain | chain:1-1009 |
| checksum | 3D059CD22B8BAF53 |
| comment | FUNCTION Effector of small Rab GTPases RAB8A and RAB13 which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins (PubMed:16525024, PubMed:18094055, PubMed:20008558, PubMed:23100251, PubMed:23890175). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (PubMed:33976349).SUBUNIT Interacts with RAB13 (GTP-bound form); competes with RAB8A and is involved in tight junctions assembly (PubMed:16525024, PubMed:18094055, PubMed:20008558). Interacts with RAB8A; competes with RAB13 and is involved in E-cadherin endocytic recycling (PubMed:18094055). Interacts with RAB8B (PubMed:18094055). Interacts (preferentially in opened conformation) with ACTN1 and ACTN4; stimulated by RAB13 activation. Interacts (via calponin-homology (CH) domain) with the filamins FLNA, FLNB and FLNC (via actin-binding domain) (PubMed:18332111, PubMed:23100251, PubMed:23890175).INTERACTION Detected in brain, lung, liver and kidney (at protein level).DOMAIN Exists in a closed and an open conformation due to interaction of the C-terminal coiled-coil domain with an N-terminal region including the calponin-homology (CH) and the LIM zinc-binding domain. The conformational change is regulated by RAB13 and RAB8A. Adopts its closed form upon interaction with RAB8A and interaction with RAB13 causes conformational change from closed to open. |
| created | [InstanceEdit:5083144] Weiser, JD |
| description | recommendedName: MICAL-like protein 2 alternativeName: Junctional Rab13-binding protein alternativeName: Molecule interacting with CasL-like 2 shortName: MICAL-L2 |
| geneName | Micall2 Jrab |
| identifier | Q3TN34 |
| isSequenceChanged | FALSE |
| keyword | Cell junction Cell membrane Cell projection Coiled coil Cytoplasm Cytoskeleton Endosome LIM domain Membrane Metal-binding Phosphoprotein Reference proteome Tight junction Zinc |
| modified | [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | Micall2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | MILK2_MOUSE Q3TPY3 Q3UB65 |
| sequenceLength | 1009 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9605217] Micall2 [cytosol] [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q3TN34 Micall2 (5083176)
