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Details on Person UniProt:P0DM65 Becn2
| Class:Id | ReferenceGeneProduct:5083152 |
|---|---|
| _chainChangeLog | chain:1-447 added on Fri February 6 2015 |
| _displayName | UniProt:P0DM65 Becn2 |
| _timestamp | 2023-11-03 16:00:14 |
| chain | chain:1-447 |
| checksum | F5114EB9DB6320B9 |
| comment | FUNCTION Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1.SUBUNIT Homodimer (via coiled-coil domain) (By similarity). Interacts (via coiled-coil domain) with ATG14 (via coiled-coil domain); this interaction is tighter than BECN2 self-association (PubMed:23954414). Interacts with AMBRA1, UVRAG and PIK3C3/VPS34; these interactions are not disrupted by starvation (PubMed:23954414). Does not interact with RUBCN. Interacts (via N-terminus) with GPRASP1/GASP1; the interaction is direct (PubMed:23954414).SUBCELLULAR LOCATION Expressed in brain, skeletal muscle, placenta, thymus and uterus. Expressed at a lower level in liver, testis, stomach, and 17-day-old embryos.DISRUPTION PHENOTYPE Decreased embryonic viability: embryonic and postnatal survival rates of homozygous mutant mice are markedly lower. Heterozygous knockout mice show defects in autophagy, increased levels of Cnr1 receptor, elevated food intake, and obesity and insulin resistance.SIMILARITY Belongs to the beclin family. |
| created | [InstanceEdit:5083144] Weiser, JD |
| description | recommendedName: fullName evidence="4"Beclin-2 |
| geneName | Becn2 |
| identifier | P0DM65 |
| isSequenceChanged | FALSE |
| keyword | Autophagy Coiled coil Cytoplasm Reference proteome |
| modified | [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Becn2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | BECN2_MOUSE S5WDD2 |
| sequenceLength | 447 |
| species | [Species:48892] Mus musculus |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P0DM65 Becn2 (5083152)
