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Details on Person UniProt:D3ZKX9 Aloxe3
| Class:Id | ReferenceGeneProduct:5083149 |
|---|---|
| _chainChangeLog | chain:1-711 added on Fri February 6 2015 |
| _displayName | UniProt:D3ZKX9 Aloxe3 |
| _timestamp | 2025-02-21 19:39:36 |
| chain | chain:1-711 |
| checksum | 41C3D9BBC6C4532B |
| comment | FUNCTION Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced lipoxygenases activity. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols and ketones. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites (By similarity). Also plays a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG (By similarity). Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia (PubMed:23382512).CATALYTIC ACTIVITY a hydroperoxyeicosatetraenoate = a hydroxy-epoxy-eicosatetraenoateCATALYTIC ACTIVITY a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2OCATALYTIC ACTIVITY (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoateCATALYTIC ACTIVITY (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoateCATALYTIC ACTIVITY (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoateCATALYTIC ACTIVITY (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoateCATALYTIC ACTIVITY (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoateCATALYTIC ACTIVITY (13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoateCATALYTIC ACTIVITY N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine = a N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoyloxy]acyl-beta-D-glucosyl-(1<->1)-sphing-4E-enineCATALYTIC ACTIVITY a N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]-acylsphin-4E-enine = a N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoyloxy]-acylsphing-4E-enineCATALYTIC ACTIVITY (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2OCATALYTIC ACTIVITY (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2OCATALYTIC ACTIVITY (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2OCATALYTIC ACTIVITY (13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)-octadecadienoate + H2OCATALYTIC ACTIVITY (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = (10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoateCATALYTIC ACTIVITY (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2OCATALYTIC ACTIVITY (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2OCOFACTOR Binds 1 Fe cation per subunit.PATHWAY Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis.PATHWAY Lipid metabolism; sphingolipid metabolism.SUBCELLULAR LOCATION Belongs to the lipoxygenase family.ONLINE INFORMATION about water - Issue 153 of September 2013 |
| created | [InstanceEdit:5083144] Weiser, JD |
| description | recommendedName: fullName evidence="6"Hydroperoxide isomerase ALOXE3 alternativeName: fullName evidence="2"Epidermis-type lipoxygenase 3 shortName: Epidermal LOX-3 shortName evidence="2"e-LOX-3 shortName: eLOX-3 alternativeName: fullName evidence="6"Hydroperoxy dehydratase ALOXE3 alternativeName: Hydroperoxy icosatetraenoate dehydratase ecNumber evidence="2"4.2.1.152 alternativeName: Hydroperoxy icosatetraenoate isomerase ecNumber evidence="2"5.4.4.7 |
| geneName | Aloxe3 |
| identifier | D3ZKX9 |
| isSequenceChanged | FALSE |
| keyword | Cytoplasm Dioxygenase Fatty acid metabolism Iron Isomerase Lipid metabolism Lyase Metal-binding Oxidoreductase Reference proteome |
| modified | [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8856987] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9698430] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | Aloxe3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | LOXE3_RAT |
| sequenceLength | 711 |
| species | [Species:48895] Rattus norvegicus |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:D3ZKX9 Aloxe3 (5083149)
