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Details on Person Methylcrotonyl CoA carboxylase (MCCA) catalyzes the reversib...
| Class:Id | Summation:508304 |
|---|---|
| _displayName | Methylcrotonyl CoA carboxylase (MCCA) catalyzes the reversib... |
| _timestamp | 2010-02-11 21:52:59 |
| created | [InstanceEdit:508306] D'Eustachio, P, 2010-02-11 |
| modified | [InstanceEdit:508313] D'Eustachio, P, 2010-02-11 |
| text | Methylcrotonyl CoA carboxylase (MCCA) catalyzes the reversible reaction of beta-methylglutaconyl-CoA, ADP, orthophosphate, and H2O to form beta-methylcrotonyl-CoA, ATP, and CO2. Active MCCA is composed of two polypeptides, MCCA1 and MCCA2 (Baumgartner et al. 2001; Holzinger et al. 2001). The enzyme has been purified from fibroblast mitochondria. By analogy to the more thoroughly studied bovine homologue, MCCA is thought to be a hexamer of six MCCA1:MCCA2 dimers, and the MCCA1 polypeptides are thought to have biotin moieties covalently bound to a lysine residue at position 681 in the polypeptide chain. Mitochondrial import of MCCA1 and 2 is associated with removal of aminoterminal mitochondrial targeting sequences but the exact lengths of these sequences have not been determined. |
| (summation) | [Reaction:508308] beta-methylglutaconyl-CoA + ADP + orthophosphate <=> beta-methylcrotonyl-CoA + ATP + HCO3- (MCCA) [Homo sapiens] |
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No pathways have been reviewed or authored by Methylcrotonyl CoA carboxylase (MCCA) catalyzes the reversib... (508304)
