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Details on Person SYK is a substrate for JAK1

Class:IdReaction:508282
_displayNameSYK is a substrate for JAK1
_doReleaseTRUE
_timestamp2018-07-03 10:22:31
authored[InstanceEdit:744679] Ray, KP, 2010-05-17
catalystActivity[CatalystActivity:508440] protein tyrosine kinase activity of IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane]
catalystActivityReference[CatalystActivityReference:9643374] protein tyrosine kinase activity of IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation
compartment[Compartment:876] plasma membrane
created[InstanceEdit:508272] Jupe, S, 2010-02-11
edited[InstanceEdit:924611] Jupe, S, 2010-08-06
input[Complex:508449] IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:451930] Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation
modified[InstanceEdit:508298] Jupe, S, 2010-02-11
[InstanceEdit:508450] Jupe, S, 2010-02-12
[InstanceEdit:918253] Jupe, S, 2010-08-02
[InstanceEdit:926765] Jupe, S, 2010-08-06
[InstanceEdit:941875] Jupe, S, 2010-09-06
[InstanceEdit:1168657] Jupe, S, 2011-01-05
[InstanceEdit:1213522] Jupe, S, 2011-02-11
[InstanceEdit:1233244] Jupe, S, 2011-03-17
[InstanceEdit:9020559] Duenas, Corina, 2017-09-07
[InstanceEdit:9032271] Orlic-Milacic, Marija, 2017-12-08
[InstanceEdit:9612921] Orlic-Milacic, Marija, 2018-07-03
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameSYK is a substrate for JAK1
output[Complex:508438] IL2:IL2R trimer:p-JAK1:JAK3:p-SYK [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2011-03-15
reviewed[InstanceEdit:1213492] Villarino, A, 2011-02-11
[InstanceEdit:1233246] Dooms, H, 2011-03-17
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1224994] R-HSA-508282.6
summation[Summation:508299] Studies have shown that coexpression of Syk with catalytical...
(hasEvent)[Pathway:9020558] Interleukin-2 signaling [Homo sapiens]
(updatedInstance)[_UpdateTracker:9779110] Update Tracker - [Reaction:508282] SYK is a substrate for JAK1 - v66:[addInput, addOutput]
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