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Details on Person Gab2 binds the p85 subunit of Class 1A PI3 kinases

Class:Id	Reaction:508247
_displayName	Gab2 binds the p85 subunit of Class 1A PI3 kinases
_doRelease	TRUE
_timestamp	2011-06-02 11:32:45
authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:508240] Jupe, S, 2010-02-11
edited	[InstanceEdit:924611] Jupe, S, 2010-08-06
input	[DefinedSet:508248] p85-containing Class 1A PI3Ks [cytosol] [Homo sapiens] [DefinedSet:912533] Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] [Homo sapiens] [DefinedSet:508248] p85-containing Class 1A PI3Ks [cytosol] [Homo sapiens] [DefinedSet:508248] p85-containing Class 1A PI3Ks [cytosol] [Homo sapiens] [DefinedSet:508248] p85-containing Class 1A PI3Ks [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:508013] Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation [LiteratureReference:912551] Engagement of Gab1 and Gab2 in erythropoietin signaling
modified	[InstanceEdit:508250] Jupe, S, 2010-02-11 [InstanceEdit:538986] Jupe, S, 2010-03-09 [InstanceEdit:561124] Jupe, S, 2010-03-25 [InstanceEdit:912521] Jupe, S, 2010-07-09 [InstanceEdit:912541] Jupe, S, 2010-07-09 [InstanceEdit:912554] Jupe, S, 2010-07-09 [InstanceEdit:912661] Jupe, S, 2010-07-12 [InstanceEdit:914195] Jupe, S, 2010-07-23 [InstanceEdit:918253] Jupe, S, 2010-08-02 [InstanceEdit:926764] Jupe, S, 2010-08-06 [InstanceEdit:926772] Jupe, S, 2010-08-06 [InstanceEdit:941868] Jupe, S, 2010-09-06 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:1233244] Jupe, S, 2011-03-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Gab2 binds the p85 subunit of Class 1A PI3 kinases
output	[DefinedSet:912535] Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:912527] SHC1 mediates cytokine-induced phosphorylation of GAB2 [Homo sapiens] [BlackBoxEvent:453104] Phosphorylated SHC1 recruits GRB2:GAB2 [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:1213492] Villarino, A, 2011-02-11 [InstanceEdit:1233246] Dooms, H, 2011-03-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104772] R-HSA-508247.2
summation	[Summation:508244] Shc promotes Gab2 tyrosine phosphorylation via Grb2 (Gu et a...
(hasEvent)	[Pathway:912526] Interleukin receptor SHC signaling [Homo sapiens]
(precedingEvent)	[Reaction:879906] PI3K activates Akt kinase
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No pathways have been reviewed or authored by Gab2 binds the p85 subunit of Class 1A PI3 kinases (508247)