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Details on Person Recruitment of Sos1 to the receptor complex brings it into c...
| Class:Id | Summation:508245 |
|---|---|
| _displayName | Recruitment of Sos1 to the receptor complex brings it into c... |
| _timestamp | 2010-03-25 17:46:10 |
| created | [InstanceEdit:508240] Jupe, S, 2010-02-11 |
| literatureReference | [LiteratureReference:179827] Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2 [LiteratureReference:208231] Integrating signals from RTKs to ERK/MAPK |
| modified | [InstanceEdit:508250] Jupe, S, 2010-02-11 [InstanceEdit:508254] Jupe, S, 2010-02-11 [InstanceEdit:561124] Jupe, S, 2010-03-25 |
| text | Recruitment of Sos1 to the receptor complex brings it into contact with membrane-associated Ras-GDP. Interactions with Ras modulate Sos1 activity in a two-step manner (McKay & Morrison, 2007). Sos1 acts as a guanine exchange factor for Ras (Chardin et al. 1993), activating the Ras-Raf-MAPK pathway. |
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No pathways have been reviewed or authored by Recruitment of Sos1 to the receptor complex brings it into c... (508245)
