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Details on Person Phosphorylation of HSF1 at Ser326 induces transactivation

Class:IdReaction:5082405
_displayNamePhosphorylation of HSF1 at Ser326 induces transactivation
_doReleaseTRUE
_timestamp2014-11-20 02:50:00
authored[InstanceEdit:4793943] Shamovsky, V, 2013-10-28
catalystActivity[CatalystActivity:5083660] protein serine/threonine kinase activity of mTORC1 dimer [nucleoplasm]
catalystActivityReference[CatalystActivityReference:9643516] protein serine/threonine kinase activity of mTORC1 dimer [nucleoplasm] mTOR is essential for the proteotoxic stress response, HSF1 activation and heat shock protein synthesis
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:5082392] Shamovsky, V, 2013-11-05
edited[InstanceEdit:5324627] Shamovsky, V, 2014-02-17
input[Complex:4793790] HSF1 trimer [nucleoplasm] [Homo sapiens]
[SimpleEntity:29358] ATP [nucleoplasm]
isChimericFALSE
literatureReference[LiteratureReference:5082377] Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress
[LiteratureReference:5083640] mTOR is essential for the proteotoxic stress response, HSF1 activation and heat shock protein synthesis
modified[InstanceEdit:5083129] Shamovsky, V, 2013-11-05
[InstanceEdit:5083679] Shamovsky, V, 2013-11-07
[InstanceEdit:5148862] Shamovsky, V, 2013-11-18
[InstanceEdit:5324681] Shamovsky, V, 2014-02-17
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePhosphorylation of HSF1 at Ser326 induces transactivation
output[Complex:5082354] p-S326-HSF1 trimer [nucleoplasm] [Homo sapiens]
[SimpleEntity:113582] ADP [nucleoplasm]
releaseDate2014-03-12
reviewed[InstanceEdit:5324628] Pani, Bibhusita, 2014-02-17
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5644907] R-HSA-5082405.3
summation[Summation:5083668] Mutagenesis experiments and functional studies suggest that ...
(hasEvent)[Pathway:3371571] HSF1-dependent transactivation [Homo sapiens]
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