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Details on Person Pcsk1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 (7-37)

Class:Id	Reaction:508205
_displayName	Pcsk1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 (7-37)
_doRelease	TRUE
_timestamp	2014-02-04 22:52:03
authored	[InstanceEdit:508213] May, B, 2010-02-11
catalystActivity	[CatalystActivity:216803] serine-type endopeptidase activity of Pcsk1 [secretory granule lumen]
compartment	[Compartment:1462052] secretory granule lumen
created	[InstanceEdit:508224] May, B, 2010-02-11
edited	[InstanceEdit:508224] May, B, 2010-02-11
input	[EntityWithAccessionedSequence:508219] Proglucagon [secretory granule lumen] [Mus musculus]
isChimeric	FALSE
literatureReference	[LiteratureReference:381796] Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects
modified	[InstanceEdit:771698] May, B, 2010-05-21 [InstanceEdit:847708] May, B, 2010-05-30 [InstanceEdit:927719] May, B, 2010-08-06 [InstanceEdit:941847] May, B, 2010-09-04 [InstanceEdit:2684523] D'Eustachio, P, 2012-11-30 [InstanceEdit:2876561] May, B, 2012-12-23 [InstanceEdit:5251722] May, B, 2014-02-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Pcsk1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 (7-37)
output	[EntityWithAccessionedSequence:508209] Glucagon-like Peptide-1 (7-37) [secretory granule lumen] [Mus musculus]
releaseDate	2010-09-21
reviewed	[InstanceEdit:879883] Bloom, SR, 2010-06-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:1104719] R-MMU-508205.2
summation	[Summation:508215] Prohormone convertase 1 (PC1/3, NEC, Pcsk1) cleaves progluca...
(inferredFrom)	[BlackBoxEvent:381798] PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 [Homo sapiens]
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No pathways have been reviewed or authored by Pcsk1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 (7-37) (508205)