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Details on Person a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2]

Class:Id	Reaction:508179
_displayName	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2]
_doRelease	TRUE
_timestamp	2024-07-30 09:26:44
authored	[InstanceEdit:517475] D'Eustachio, P, 2010-02-18
catalystActivity	[CatalystActivity:70711] branched-chain-amino-acid:2-oxoglutarate transaminase activity of BCAT2 dimer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643240] branched-chain-amino-acid transaminase activity of BCAT2 dimer [mitochondrial matrix] The structure of human mitochondrial branched-chain aminotransferase
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:508183] D'Eustachio, P, 2010-02-10
crossReference	[DatabaseIdentifier:9917058] RHEA:18323 [DatabaseIdentifier:9917061] RHEA:24803 [DatabaseIdentifier:9917059] RHEA:24815
edited	[InstanceEdit:517475] D'Eustachio, P, 2010-02-18
input	[DefinedSet:508181] KIC, KMVA, KIV [mitochondrial matrix] [SimpleEntity:113552] L-Glu [mitochondrial matrix]
isChimeric	FALSE
literatureReference	[LiteratureReference:508232] Cloning of the rat and human mitochondrial branched chain aminotransferases (BCATm) [LiteratureReference:70705] The structure of human mitochondrial branched-chain aminotransferase. [LiteratureReference:508177] Crystal structures of human mitochondrial branched chain aminotransferase reaction intermediates: ketimine and pyridoxamine phosphate forms
modified	[InstanceEdit:508193] D'Eustachio, P, 2010-02-10 [InstanceEdit:508233] D'Eustachio, P, 2010-02-11 [InstanceEdit:517476] D'Eustachio, P, 2010-02-18 [InstanceEdit:532423] D'Eustachio, P, 2010-02-26 [InstanceEdit:532680] D'Eustachio, P, 2010-03-02 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9908873] Stephan, Ralf, 2024-04-23 [InstanceEdit:9917064] Stephan, Ralf, 2024-07-30
name	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2]
negativePrecedingEvent	[NegativePrecedingEvent:9908864] Futile Cycle: leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]
output	[SimpleEntity:113594] 2OG [mitochondrial matrix] [DefinedSet:508190] Leu, Ile, Val [mitochondrial matrix]
releaseDate	2010-03-16
reverseReaction	[Reaction:70724] leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] [Homo sapiens] [Reaction:508179] a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] [Homo sapiens]
reviewed	[InstanceEdit:532425] Jassal, Bijay, 2010-02-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105807] R-HSA-508179.5
summation	[Summation:508230] Mitochondrial branched-chain-amino-acid aminotransferase (BC...
(hasEvent)	[Pathway:70895] Branched-chain amino acid catabolism [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9908869] Futile Cycle: a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2]
(reverseReaction)	[Reaction:70724] leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] [Homo sapiens]
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No pathways have been reviewed or authored by a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (508179)