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Details on Person UniProt:P16442 ABO
| Class:Id | ReferenceGeneProduct:50808 |
|---|---|
| _chainChangeLog | chain:1-354 added on Fri February 6 2015;chain:54-354 added on Fri February 6 2015 |
| _displayName | UniProt:P16442 ABO |
| _timestamp | 2026-02-20 21:57:03 |
| chain | chain:1-354 chain:54-354 |
| checksum | A03DA16E630C1608 |
| comment | FUNCTION This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of N-acetyl-alpha-D-galactosamine (GalNAc)) or to the B antigen (by addition of galactose (Gal)), whereas O individuals lack such activity and express the H antigen precursor unmodified.FUNCTION Catalyzes the transfer of GalNAc or Gal in an alpha1,3 linkage to the terminal Gal of all five types of naturally occurring H antigens, forming the antigenic structures of the A and B blood groups.CATALYTIC ACTIVITY an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + UDP + H(+)CATALYTIC ACTIVITY an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose = an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + UDP + H(+)CATALYTIC ACTIVITY an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-galactosamine = an alpha-D-GalNAc-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + UDP + H(+)CATALYTIC ACTIVITY an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-galactosamine = an alpha-D-GalNAc-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP + H(+)CATALYTIC ACTIVITY an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + UDP-alpha-D-galactose = an alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + UDP + H(+)CATALYTIC ACTIVITY an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-alpha-D-galactose = an alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP + H(+)CATALYTIC ACTIVITY an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc derivative + UDP-alpha-D-galactose = an alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->3)-alpha-D-GalNAc derivative + UDP + H(+)CATALYTIC ACTIVITY an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GalNAc derivative + UDP-alpha-D-galactose = an alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->3)-beta-D-GalNAc derivative + UDP + H(+)CATALYTIC ACTIVITY an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-Glc derivative + UDP-alpha-D-galactose = an alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->4)-beta-D-Glc derivative + UDP + H(+)COFACTOR Binds 1 Mn(2+) ion per subunit.BIOPHYSICOCHEMICAL PROPERTIES kcat is 1.3 sec(-1) for type I H-antigen (A transferase) (PubMed:16326711). kcat is 0.5 sec(-1) for type I H-antigen (B transferase) (PubMed:16326711). kcat is 1.8 sec(-1) for type II H-antigen (A transferase) (PubMed:16326711). kcat is 1.2 sec(-1) for type II H-antigen (B transferase) (PubMed:16326711).PATHWAY Protein modification; protein glycosylation.SUBCELLULAR LOCATION Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.TISSUE SPECIFICITY Expressed at high levels in testis. Also expressed in pancreas, uterus and lung and salivary gland.DOMAIN The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis.PTM The soluble form derives from the membrane form by proteolytic processing.POLYMORPHISM Genetic variations in ABO define the ABO blood group system [MIM:616093]. The ABO blood group system is one of the most important blood group systems in transfusion medicine. The ABO blood group involves 3 carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of GalNAc) or to the B antigen (by addition of Gal). There are only 4 amino acid differences between A and B transferases in the catalytic domain, two of which (Leu266Met and Gly268Ala) are primarily responsible for the substrate specificity. The group O phenotype results from variations in ABO that cause a loss of glycosyltransferase activity. The most common group O allele results from a single nucleotide deletion near the 5' end of the gene (NM_020469.2:c.261del) that causes a frameshift and early termination with no active enzyme production (p.Thr88Profs*31). The sequence shown is that of ABO*A1.01.SIMILARITY Belongs to the glycosyltransferase 6 family.ONLINE INFORMATION Histo-blood group ABO system transferaseONLINE INFORMATION Histo-blood group ABO system transferase |
| description | recommendedName: Histo-blood group ABO system transferase alternativeName: Fucosylglycoprotein 3-alpha-galactosyltransferase alternativeName: Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase alternativeName: Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase ecNumber evidence="4 13"2.4.1.40 alternativeName: Glycoprotein-fucosylgalactoside alpha-galactosyltransferase ecNumber evidence="4 13"2.4.1.37 alternativeName: Histo-blood group A transferase shortName: A transferase shortName evidence="23"GTA alternativeName: Histo-blood group B transferase shortName: B transferase shortName evidence="23"GTB alternativeName: NAGAT component recommendedName: Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form /component |
| geneName | ABO |
| identifier | P16442 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Blood group antigen Direct protein sequencing Glycoprotein Glycosyltransferase Golgi apparatus Manganese Membrane Metal-binding Proteomics identification Reference proteome Secreted Signal-anchor Transferase Transmembrane Transmembrane helix |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:5691543] Weiser, JD [InstanceEdit:8856987] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9607352] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | ABO |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | BGAT_HUMAN B0JDB9 O14758 Q14490 Q53I57 Q6ISD4 Q6KFZ2 Q70V27 Q99484 Q99485 Q9NY01 Q9UQ68 Q9UQ69 |
| sequenceLength | 354 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:9034057] ABO-A [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:9034064] ABO-B [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:9034076] sABO-B [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9034078] sABO-A [extracellular region] [Homo sapiens] |
| (referenceSequence) | [ReplacedResidue:9034032] L-arginine 176 replaced with glycine [ReplacedResidue:9034040] glycine 268 replaced with L-alanine [ReplacedResidue:9034050] glycine 235 replaced with L-serine [ReplacedResidue:9034071] L-leucine 266 replaced with L-methionine |
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No pathways have been reviewed or authored by UniProt:P16442 ABO (50808)
