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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person Diagram of Signaling by EGFR, Signaling by EGFRvIII in Cancer, Signaling by Ligand-Responsive EGFR Variants in Cancer, and Signaling by Overexpressed Wild-Type EGFR in Cancer

Class:IdPathwayDiagram:507988
_displayNameDiagram of Signaling by EGFR, Signaling by EGFRvIII in Cancer, Signaling by Ligand-Responsive EGFR Variants in Cancer, and Signaling by Overexpressed Wild-Type EGFR in Cancer
_timestamp2024-07-31 11:47:21
created[InstanceEdit:507989] Wu, G, 2010-02-10
height1895
modified[InstanceEdit:1679954] Wu, G, 2011-10-20
[InstanceEdit:1793233] Orlic-Milacic, Marija, 2011-10-21
[InstanceEdit:1996355] Orlic-Milacic, Marija, 2011-11-19
[InstanceEdit:1996378] Orlic-Milacic, Marija, 2011-11-19
[InstanceEdit:2008173] Orlic-Milacic, Marija, 2011-11-21
[InstanceEdit:5638081] Orlic-Milacic, Marija, 2014-11-13
[InstanceEdit:5638082] Orlic-Milacic, Marija, 2014-11-13
[InstanceEdit:5638083] Orlic-Milacic, Marija, 2014-11-13
[InstanceEdit:5638084] Orlic-Milacic, Marija, 2014-11-13
[InstanceEdit:5638086] Orlic-Milacic, Marija, 2014-11-13
[InstanceEdit:5638128] Orlic-Milacic, Marija, 2014-11-13
[InstanceEdit:5638129] Orlic-Milacic, Marija, 2014-11-13
[InstanceEdit:5638130] Orlic-Milacic, Marija, 2014-11-13
[InstanceEdit:5638172] Orlic-Milacic, Marija, 2014-11-13
[InstanceEdit:5638306] Orlic-Milacic, Marija, 2014-11-13
[InstanceEdit:5638337] Orlic-Milacic, Marija, 2014-11-13
[InstanceEdit:5638338] Orlic-Milacic, Marija, 2014-11-13
[InstanceEdit:5691371] Rothfels, Karen, 2015-05-06
[InstanceEdit:5691490] Wu, G, 2015-05-08
[InstanceEdit:6787699] Garapati, Phani Vijay, 2015-07-15
[InstanceEdit:6797372] Orlic-Milacic, Marija, 2015-09-09
[InstanceEdit:6797590] Orlic-Milacic, Marija, 2015-09-14
[InstanceEdit:8855180] Wu, G, 2016-02-02
[InstanceEdit:8864030] Orlic-Milacic, Marija, 2016-03-10
[InstanceEdit:8864031] Orlic-Milacic, Marija, 2016-03-10
[InstanceEdit:8867052] Rothfels, Karen, 2016-04-05
[InstanceEdit:8869709] Rothfels, Karen, 2016-05-06
[InstanceEdit:8934516] Orlic-Milacic, Marija, 2016-08-09
[InstanceEdit:8934518] Orlic-Milacic, Marija, 2016-08-09
[InstanceEdit:8934534] Orlic-Milacic, Marija, 2016-08-09
[InstanceEdit:8934540] Orlic-Milacic, Marija, 2016-08-09
[InstanceEdit:8934541] Orlic-Milacic, Marija, 2016-08-09
[InstanceEdit:8951492] Jassal, Bijay, 2016-12-07
[InstanceEdit:8979569] Jassal, Bijay, 2017-02-27
[InstanceEdit:9031667] Orlic-Milacic, Marija, 2017-12-01
[InstanceEdit:9031692] Orlic-Milacic, Marija, 2017-12-01
[InstanceEdit:9031693] Orlic-Milacic, Marija, 2017-12-01
[InstanceEdit:9031696] Orlic-Milacic, Marija, 2017-12-01
[InstanceEdit:9031703] Orlic-Milacic, Marija, 2017-12-01
[InstanceEdit:9031710] Orlic-Milacic, Marija, 2017-12-01
[InstanceEdit:9038402] Orlic-Milacic, Marija, 2018-02-26
[InstanceEdit:9617899] Orlic-Milacic, Marija, 2018-08-31
[InstanceEdit:9624492] Rothfels, Karen, 2018-10-11
[InstanceEdit:9624500] Rothfels, Karen, 2018-10-11
[InstanceEdit:9628541] Rothfels, Karen, 2018-11-09
[InstanceEdit:9628979] Matthews, Lisa, 2018-11-14
[InstanceEdit:9645116] Wu, G, 2019-05-03
[InstanceEdit:9657155] Orlic-Milacic, Marija, 2019-08-08
[InstanceEdit:9674880] Orlic-Milacic, Marija, 2020-01-28
[InstanceEdit:9698976] Matthews, Lisa, 2020-09-03
[InstanceEdit:9851406] Orlic-Milacic, Marija, 2023-10-25
[InstanceEdit:9851449] Orlic-Milacic, Marija, 2023-10-25
[InstanceEdit:9851454] Orlic-Milacic, Marija, 2023-10-25
[InstanceEdit:9852725] Orlic-Milacic, Marija, 2023-11-06
[InstanceEdit:9859777] D'Eustachio, Peter, 2024-01-25
[InstanceEdit:9859778] D'Eustachio, Peter, 2024-01-25
[InstanceEdit:9865824] Orlic-Milacic, Marija, 2024-03-19
[InstanceEdit:9917184] Orlic-Milacic, Marija, 2024-07-31
representedPathway[Pathway:177929] Signaling by EGFR [Homo sapiens]
[Pathway:5637812] Signaling by EGFRvIII in Cancer [Homo sapiens]
[Pathway:5637815] Signaling by Ligand-Responsive EGFR Variants in Cancer [Homo sapiens]
[Pathway:5638302] Signaling by Overexpressed Wild-Type EGFR in Cancer [Homo sapiens]
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membrane</displayName> </Properties> </org.gk.render.Note> <org.gk.render.RenderableComplex id="2080" reactomeId="8875480" position="2819 572" bounds="2783 553 72 38" textPosition="2784 555" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CIN85:endophilin</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2151" reactomeId="8951489" position="2387 433" bounds="2322 408 131 50" textPosition="2323 408" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2265" reactomeId="1806218" position="551 1043" bounds="503 1032 97 22" textPosition="504 1032" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PIK3CA:PIK3R1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2287" reactomeId="180282" position="450 1294" bounds="410 1278 81 32" textPosition="410 1274" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>GRB2:GAB1:PIP3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="2290" reactomeId="9038397" position="988 1077" bounds="931 1058 114 39" textPosition="936 1059"> <Properties> <displayName>GRB2:GAB1,GRB2:GAB1:PIP3</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="2299" reactomeId="9624194" position="430 138" bounds="373 118 114 41" textPosition="380 127"> <Properties> <displayName>EGF-like ligands</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="2303" reactomeId="9624419" position="643 176" bounds="586 157 115 38" textPosition="597 159" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>EGFR:EGF-like ligands</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2306" reactomeId="9624420" position="894 186" bounds="824 160 140 53" textPosition="825 177" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>EGF-like ligands:EGFR dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="2308" reactomeId="113592" position="1081 191" bounds="1064 177 35 28" textPosition="1066 180"> <Properties> <displayName>ATP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="2311" reactomeId="29370" position="1226 194" bounds="1205 181 43 27" textPosition="1210 183" /> <org.gk.render.RenderableComplex id="2312" reactomeId="9624425" position="1412 185" bounds="1361 160 102 50" textPosition="1369 160" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>EGF-like ligands:p-6Y EGFR dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="2318" reactomeId="29356" position="1228 566" bounds="1203 551 51 30" textPosition="1211 555" /> <org.gk.render.RenderableComplex id="2323" reactomeId="9624427" position="1712 223" bounds="1656 200 112 47" textPosition="1659 211" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>EGF-like ligands:p-6Y EGFR:SHC1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="2325" reactomeId="113592" position="1776 273" bounds="1756 260 41 27" textPosition="1761 262" /> <org.gk.render.RenderableChemical id="2337" reactomeId="29356" position="1300 796" bounds="1275 781 51 30" textPosition="1283 785" /> <org.gk.render.RenderableProteinDrug id="2342" reactomeId="1248673" position="101 143" bounds="50 132 102 22" textPosition="65 132" bgColor="184 154 230" fgColor="255 0 0" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>Cetuximab</displayName> </Properties> </org.gk.render.RenderableProteinDrug> <org.gk.render.RenderableComplex id="2343" reactomeId="1248675" position="206 399" bounds="162 380 89 39" textPosition="171 383" bgColor="184 154 230" fgColor="161 1 2" lineColor="255 0 0" isForDrug="true" isForDisease="true" hideComponents="true"> <Properties> <displayName>EGFR:Cetuximab</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2345" reactomeId="9674636" position="468 588" bounds="447 577 42 22" textPosition="449 570"> <Properties> <displayName>AAMP</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="2346" reactomeId="9674862" position="292 444" bounds="254 426 76 37" textPosition="270 427" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>EGFR:AAMP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="2368" reactomeId="9851390" position="489 269" bounds="452 248 74 43" textPosition="454 245"> <Properties> <displayName>FAM83B,(FAM83A, FAM83D)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="2369" reactomeId="9851427" position="349 285" bounds="297 262 104 46" textPosition="301 258" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>EGFR:FAM83B,(FAM83A, FAM83D)</displayName> </Properties> </org.gk.render.RenderableComplex> </Nodes> <Edges> <org.gk.render.RenderableReaction id="6" reactomeId="182986" points="3205 941, 3206 890, 3203 854" position="3206 890" lineWidth="1.0"> <Inputs> <Input id="1209" points="3178 955" /> <Input id="120" points="3263 959" /> </Inputs> <Outputs> <Output id="59" /> </Outputs> <Catalysts> <Catalyst id="120" points="3281 927, 3254 897" /> </Catalysts> <Properties> <displayName>CBL-mediated ubiquitination of CIN85</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="7" reactomeId="183036" points="2869 306, 2883 306, 2903 303" position="2883 306" lineWidth="1.0"> <Inputs> <Input id="129" points="2856 302" /> <Input id="1164" stoichiometry="2" points="2854 339" /> </Inputs> <Outputs> <Output id="103" /> </Outputs> <Catalysts> <Catalyst id="129" points="2856 270, 2875 262" /> </Catalysts> <Inhibitors> <Inhibitor id="1941" points="1214 267, 1360 142, 2889 200" /> </Inhibitors> <Properties> <displayName>Ubiquitination of stimulated EGFR (CBL:GRB2)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="10" reactomeId="212713" points="194 723, 736 754, 1245 750" position="736 754" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="22" /> </Inputs> <Outputs> <Output id="34" points="184 816" /> <Output id="2312" points="1404 213" /> </Outputs> <Properties> <displayName>Active PLC-gamma1 dissociates from EGFR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="11" reactomeId="212710" points="131 619, 134 638, 131 653" position="134 638" lineWidth="1.0"> <Inputs> <Input id="134" points="132 584" /> <Input id="582" stoichiometry="4" points="165 618" /> </Inputs> <Outputs> <Output id="583" stoichiometry="4" points="184 660" /> <Output id="22" points="132 679" /> </Outputs> <Catalysts> <Catalyst id="134" points="112 584, 84 617" /> </Catalysts> <Properties> <displayName>EGFR activates PLC-gamma1 by phosphorylation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="13" reactomeId="177927" points="200 1055, 200 1083, 180 1103" position="200 1083" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2265" points="500 1044" /> <Input id="127" points="172 1040" /> </Inputs> <Outputs> <Output id="96" /> </Outputs> <Properties> <displayName>PI3K binds to EGF:EGFR:GRB2:GAB1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="17" reactomeId="183094" points="2180 813, 2153 472, 2223 431" position="2153 472" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="39" points="2208 519" /> <Input id="48" points="1929 776" /> </Inputs> <Outputs> <Output id="15" /> </Outputs> <Properties> <displayName>CDC42:GTP binds CBL:Beta-Pix</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="18" reactomeId="177920" points="727 1004, 728 1035, 728 1091, 729 1125" position="728 1035" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="49" points="767 983" /> <Input id="1102" points="695 991" /> </Inputs> <Outputs> <Output id="69" /> </Outputs> <Properties> <displayName>Binding of GRB2 to GAB1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="24" reactomeId="183067" points="1675 801, 1686 854, 1700 898, 2549 867, 2616 330" position="1700 898" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="68" stoichiometry="2" points="1690 746" /> <Input id="2312" points="1422 213" /> </Inputs> <Outputs> <Output id="87" /> </Outputs> <Properties> <displayName>Localization of CBL:GRB2 to the membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="28" reactomeId="177933" points="1791 231, 1817 229, 1836 234" position="1817 229" lineWidth="1.0"> <Inputs> <Input id="2323" points="1771 228" /> <Input id="2325" stoichiometry="2" points="1780 257" /> </Inputs> <Outputs> <Output id="112" points="1887 230" /> <Output id="585" stoichiometry="2" points="1860 276" /> </Outputs> <Catalysts> <Catalyst id="2323" points="1745 197, 1781 175" /> </Catalysts> <Properties> <displayName>SHC1 phosphorylation by phosphorylated EGFR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="29" reactomeId="177946" points="301 208, 302 183, 299 153" position="302 183" lineWidth="1.0"> <Inputs> <Input id="2" /> </Inputs> <Outputs> <Output id="133" /> </Outputs> <Catalysts> <Catalyst id="141" points="259 184" /> </Catalysts> <Properties> <displayName>Pro-EGF is cleaved to form mature EGF</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="31" reactomeId="182969" points="3382 1272, 3381 1243, 3381 1225" position="3381 1243" lineWidth="1.0"> <Inputs> <Input id="83" points="3379 1314" /> <Input id="586" stoichiometry="2" points="3349 1281" /> </Inputs> <Outputs> <Output id="107" points="3381 1208" /> <Output id="587" stoichiometry="2" points="3345 1232" /> </Outputs> <Catalysts> <Catalyst id="83" points="3387 1314, 3411 1274" /> </Catalysts> <Properties> <displayName>Phosphorylation of CBL (EGFR:CBL)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="36" reactomeId="182994" points="2797 402, 2809 419, 2839 417" position="2809 419" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2080" points="2816 550" /> <Input id="129" points="2798 326" /> </Inputs> <Outputs> <Output id="81" /> </Outputs> <Properties> <displayName>Assembly of EGFR complex in clathrin-coated vesicles</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="45" reactomeId="177935" points="360 1763, 383 1764, 411 1763" position="383 1764" lineWidth="1.0"> <Inputs> <Input id="588" points="351 1727" /> <Input id="9" points="336 1763" /> </Inputs> <Outputs> <Output id="21" points="436 1762" /> <Output id="589" points="427 1726" /> </Outputs> <Catalysts> <Catalyst id="9" points="336 1777, 368 1786" /> </Catalysts> <Properties> <displayName>SHP2 dephosphorylates Tyr 992 on EGFR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="50" reactomeId="177945" points="2408 340, 2429 347, 2447 341" position="2429 347" lineWidth="1.0"> <Inputs> <Input id="85" points="2379 359" /> <Input id="115" points="2378 318" /> </Inputs> <Outputs> <Output id="43" points="2478 327" /> <Output id="25" points="2467 374" /> </Outputs> <Catalysts> <Catalyst id="74" points="2122 255, 2123 212, 2435 213" /> </Catalysts> <Properties> <displayName>SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)</displayName> <isChanged>true</isChanged> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="51" reactomeId="177923" points="938 1778, 952 1782, 969 1780" position="952 1782" lineWidth="1.0"> <Inputs> <Input id="590" points="925 1758" /> <Input id="16" points="906 1776" /> </Inputs> <Outputs> <Output id="137" points="1072 1771" /> <Output id="591" points="987 1755" /> <Output id="122" points="1027 1822" /> </Outputs> <Catalysts> <Catalyst id="9" points="274 1792, 280 1839, 951 1827" /> </Catalysts> <Properties> <displayName>Sustained activation of SRC kinase by SHP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="52" reactomeId="177938" points="2410 325, 2419 292, 2456 321" position="2419 292" lineWidth="1.0"> <Inputs> <Input id="85" points="2374 359" /> <Input id="115" points="2390 318" /> </Inputs> <Outputs> <Output id="43" points="2475 315" /> <Output id="25" points="2470 374" /> </Outputs> <Catalysts> <Catalyst id="33" points="2268 275, 2284 234, 2394 234" /> </Catalysts> <Properties> <displayName>SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="54" reactomeId="183002" points="2344 701, 2292 485, 2341 461" position="2292 485" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="81" points="2902 451, 2900 701" /> <Input id="39" stoichiometry="2" points="2225 519" /> </Inputs> <Outputs> <Output id="2151" /> </Outputs> <Properties> <displayName>Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="56" reactomeId="182988" points="1932 740, 1953 740, 1982 740" position="1953 740" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="48" points="1917 760" /> <Input id="102" points="1918 722" /> </Inputs> <Outputs> <Output id="46" /> </Outputs> <Properties> <displayName>Sprouty lures CBL away from EGFR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="58" reactomeId="183052" points="1836 735, 1793 732, 1731 732" position="1793 732" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="48" points="1892 765" /> <Input id="38" points="1783 678" /> </Inputs> <Outputs> <Output id="68" /> </Outputs> <Properties> <displayName>CBL binds to GRB2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="63" reactomeId="177941" points="868 913, 547 956, 201 888" position="547 956" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2290" points="973 1052" /> <Input id="2312" points="1406 213, 1271 774" /> </Inputs> <Outputs> <Output id="106" /> </Outputs> <Properties> <displayName>GRB2:GAB1 binds to phosphorylated EGFR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="70" reactomeId="182990" points="3330 904, 3351 838" position="3351 838" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="120" points="3326 927" /> <Input id="40" points="3389 912" /> </Inputs> <Outputs> <Output id="131" /> </Outputs> <Properties> <displayName>Sprouty sequesters CBL away from active EGFR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="75" reactomeId="109813" points="1800 625, 1819 627, 2056 650" position="1819 627" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="105" points="1767 614" /> <Input id="38" points="1782 644" /> </Inputs> <Outputs> <Output id="78" /> </Outputs> <Properties> <displayName>GRB2-1 binds SOS1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="77" reactomeId="183089" points="3388 1409, 3385 1437, 3382 1471" position="3385 1437" lineWidth="1.0"> <Inputs> <Input id="107" points="3440 1168, 3454 1167, 3444 1388" /> <Input id="42" points="3330 1386" /> <Input id="1217" points="3335 1412" /> </Inputs> <Outputs> <Output id="5" /> </Outputs> <Catalysts> <Catalyst id="107" points="3440 1156, 3462 1149, 3473 1439" /> </Catalysts> <Properties> <displayName>CBL binds and ubiquitinates phosphorylated Sprouty</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="79" reactomeId="177934" points="1025 157, 1101 155, 1153 152" position="1101 155" lineWidth="1.0"> <Inputs> <Input id="2308" stoichiometry="12" points="1061 180" /> <Input id="2306" points="967 170" /> </Inputs> <Outputs> <Output id="2311" stoichiometry="12" points="1202 181" /> <Output id="2312" points="1358 178" /> </Outputs> <Catalysts> <Catalyst id="2306" points="952 157, 1048 116" /> </Catalysts> <Activators> <Activator id="2369" points="348 259, 343 46, 1089 46" /> </Activators> <Properties> <displayName>EGFR autophosphorylation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="84" reactomeId="183058" points="2692 304, 2711 304, 2726 305" position="2711 304" lineWidth="1.0"> <Inputs> <Input id="87" points="2677 303" /> <Input id="594" stoichiometry="2" points="2681 349" /> </Inputs> <Outputs> <Output id="129" points="2743 301" /> <Output id="595" stoichiometry="2" points="2743 349" /> </Outputs> <Catalysts> <Catalyst id="87" points="2677 279, 2697 271" /> </Catalysts> <Properties> <displayName>Phosphorylation of CBL (EGFR:GRB2:CBL)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="89" reactomeId="177936" points="2023 237, 2046 234, 2078 255" position="2046 234" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="112" points="2003 233" /> <Input id="78" points="2083 632" /> </Inputs> <Outputs> <Output id="74" /> </Outputs> <Properties> <displayName>GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="92" reactomeId="177943" points="1738 333, 1947 394, 2044 393, 2200 327" position="1947 394" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2312" points="1466 208" /> <Input id="78" points="2066 632" /> </Inputs> <Outputs> <Output id="33" /> </Outputs> <Properties> <displayName>GRB2:SOS1 complex binds to EGF:EGFR complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="98" reactomeId="183084" points="2624 509, 2629 475, 2630 427" position="2629 475" lineWidth="1.0"> <Inputs> <Input id="109" points="2669 500" /> <Input id="1192" stoichiometry="2" points="2624 551" /> </Inputs> <Outputs> <Output id="35" stoichiometry="2" points="2665 421" /> <Output id="87" points="2622 330" /> </Outputs> <Catalysts> <Catalyst id="109" points="2689 465, 2664 451" /> </Catalysts> <Properties> <displayName>CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="104" reactomeId="183055" points="1821 812, 1917 869, 3324 1314" position="1917 869" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="48" stoichiometry="2" points="1892 780" /> <Input id="2312" points="1428 213" /> </Inputs> <Outputs> <Output id="83" /> </Outputs> <Properties> <displayName>Binding of CBL to EGFR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="110" reactomeId="177926" points="678 1759, 693 1758, 707 1759" position="693 1758" lineWidth="1.0"> <Inputs> <Input id="596" points="657 1734" /> <Input id="27" points="665 1760" /> </Inputs> <Outputs> <Output id="8" points="717 1760" /> <Output id="597" points="719 1720" /> </Outputs> <Catalysts> <Catalyst id="9" points="281 1792, 287 1803, 678 1801" /> </Catalysts> <Properties> <displayName>Dephosphorylation of PAG by SHP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="111" reactomeId="177944" points="263 1570, 262 1633, 270 1735" position="262 1633" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="127" points="73 1016, 31 1020, 54 1554" /> <Input id="55" points="477 1519" /> </Inputs> <Outputs> <Output id="9" /> </Outputs> <Properties> <displayName>Activation of SHP2 through the binding to phospho-Gab1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="113" reactomeId="183072" points="3018 992, 3196 1065, 3263 1015" position="3196 1065" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="76" points="2952 513" /> <Input id="2080" points="2828 594" /> <Input id="107" points="3323 1170, 3075 1159" /> <Input id="23" points="3035 691" /> <Input id="108" points="3082 531" /> </Inputs> <Outputs> <Output id="120" /> </Outputs> <Properties> <displayName>EGFR non-clathrin mediated endocytosis</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="116" reactomeId="182993" points="3381 1117, 3379 1102, 3377 1081" position="3379 1102" lineWidth="1.0"> <Inputs> <Input id="107" points="3381 1139" /> <Input id="1187" stoichiometry="2" points="3347 1106" /> </Inputs> <Outputs> <Output id="66" /> </Outputs> <Catalysts> <Catalyst id="107" points="3404 1139, 3422 1119" /> </Catalysts> <Properties> <displayName>Ubiquitination of stimulated EGFR (CBL)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="121" reactomeId="177922" points="704 176, 792 176, 821 179" position="792 176" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2303" stoichiometry="2" /> </Inputs> <Outputs> <Output id="2306" /> </Outputs> <Activators> <Activator id="2346" points="285 423, 153 76, 739 80" /> </Activators> <Properties> <displayName>EGFR dimerization</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="123" reactomeId="177925" points="1555 198, 1603 205, 1653 213" position="1603 205" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="64" points="1742 540" /> <Input id="2312" points="1466 189" /> </Inputs> <Outputs> <Output id="2323" /> </Outputs> <Properties> <displayName>SHC1 binds to the phosphorylated EGF receptor:ligand complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="126" reactomeId="177930" points="131 925, 126 945, 123 966" position="126 945" lineWidth="1.0"> <Inputs> <Input id="106" points="135 905" /> <Input id="598" stoichiometry="5" points="161 921" /> </Inputs> <Outputs> <Output id="599" stoichiometry="5" points="161 961" /> <Output id="127" points="129 985" /> </Outputs> <Catalysts> <Catalyst id="106" points="121 905, 98 934" /> </Catalysts> <Properties> <displayName>GAB1 phosphorylation by EGFR kinase</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="135" reactomeId="177937" points="1017 205, 1094 223, 1128 231, 1194 237" position="1128 231" lineWidth="1.0"> <Inputs> <Input id="2306" points="967 196" /> <Input id="2308" stoichiometry="12" points="1061 194" /> </Inputs> <Outputs> <Output id="2312" points="1358 197" /> <Output id="2311" stoichiometry="12" points="1215 211" /> </Outputs> <Catalysts> <Catalyst id="118" points="1123 255" /> </Catalysts> <Properties> <displayName>Phosphorylation of EGFR by SRC kinase</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="138" reactomeId="177924" points="177 1766, 177 1711, 167 1681" position="177 1711" lineWidth="1.0"> <Inputs> <Input id="602" stoichiometry="3" points="157 1734" /> <Input id="9" points="209 1764" /> </Inputs> <Outputs> <Output id="130" points="159 1645" /> <Output id="603" stoichiometry="3" points="201 1669" /> </Outputs> <Catalysts> <Catalyst id="9" points="239 1735, 210 1715" /> </Catalysts> <Properties> <displayName>Dephosphorylation of Gab1 by SHP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="139" reactomeId="177939" points="106 1248, 107 1271, 107 1288" position="107 1271" lineWidth="1.0"> <Inputs> <Input id="3" points="110 1233" /> <Input id="604" points="128 1245" /> </Inputs> <Outputs> <Output id="125" points="122 1314" /> <Output id="605" points="140 1292" /> </Outputs> <Catalysts> <Catalyst id="96" points="95 1140, 58 1143, 59 1271" /> </Catalysts> <Properties> <displayName>PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="144" reactomeId="212706" points="1207 716, 842 704, 729 703, 430 696, 186 584" position="842 704" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1835" points="731 525, 825 677" /> <Input id="2312" points="1402 213" /> </Inputs> <Outputs> <Output id="134" /> </Outputs> <Properties> <displayName>Phospholipase C-gamma1 binds to the activated EGF receptor</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1084" reactomeId="183051" points="3378 1589, 3377 1561, 3378 1529" position="3377 1561" lineWidth="1.0"> <Inputs> <Input id="136" points="3310 1608" /> <Input id="142" points="3380 1618" /> </Inputs> <Outputs> <Output id="5" /> </Outputs> <Catalysts> <Catalyst id="142" points="3402 1618, 3425 1584" /> </Catalysts> <Properties> <displayName>CBL ubiquitinates Sprouty</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1115" interactionType="Activate" points="137 1350, 148 1367" position="142 1358" lineWidth="2.0"> <Inputs> <Input id="125" /> </Inputs> <Outputs> <Output id="1111" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1238" interactionType="Activate" points="184 826, 277 840" position="230 833" lineWidth="2.0"> <Inputs> <Input id="34" /> </Inputs> <Outputs> <Output id="1237" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1419" reactomeId="1218833" points="623 524, 534 452, 499 416" position="534 452" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="1830" points="385 565" /> <Input id="1420" stoichiometry="2" points="552 586" /> <Input id="1422" stoichiometry="2" points="685 558" /> </Inputs> <Outputs> <Output id="1423" /> </Outputs> <Properties> <displayName>Binding of ligand-responsive EGFR mutants to chaperoning proteins HSP90 and CDC37</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1427" reactomeId="1247999" points="548 523, 477 476, 353 363" position="477 476" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="1420" points="541 586" /> <Input id="1428" points="379 509" /> <Input id="1422" points="672 562" /> </Inputs> <Outputs> <Output id="1429" /> </Outputs> <Properties> <displayName>EGFRvIII mutant binds chaperone proteins HSP90 and CDC37</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1453" reactomeId="1248002" points="394 336, 639 333, 718 331" position="639 333" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="1429" stoichiometry="2" /> </Inputs> <Outputs> <Output id="1454" /> </Outputs> <Properties> <displayName>Ligand-independent dimerization of EGFRvIII mutant</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1576" reactomeId="1220610" points="1068 568, 1033 575, 1019 549" position="1033 575" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="1577" stoichiometry="2" points="1069 617" /> <Input id="1450" points="952 391" /> </Inputs> <Outputs> <Output id="1578" points="1119 495" /> <Output id="1579" points="933 486" /> </Outputs> <Properties> <displayName>Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1583" reactomeId="1220611" points="837 549, 824 518, 758 485" position="824 518" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="1584" stoichiometry="2" points="881 603" /> <Input id="1579" points="886 486" /> </Inputs> <Outputs> <Output id="1585" /> </Outputs> <Properties> <displayName>Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1625" reactomeId="1218824" points="602 631, 637 631, 667 631" position="637 631" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="1420" points="561 613" /> <Input id="1626" stoichiometry="2" points="563 643" /> </Inputs> <Outputs> <Output id="1627" /> </Outputs> <Properties> <displayName>HSP90 is inactivated by binding to benzaquinoid ansamycins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1897" reactomeId="177942" points="517 154, 537 151, 583 162" position="537 151" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2299" points="493 148" /> <Input id="1898" points="462 183" /> </Inputs> <Outputs> <Output id="2303" /> </Outputs> <Inhibitors> <Inhibitor id="1899" points="523 204" /> </Inhibitors> <Properties> <displayName>EGFR binds EGF ligand</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1914" reactomeId="1220613" points="673 263, 714 259, 748 260" position="714 259" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="1915" stoichiometry="2" /> </Inputs> <Outputs> <Output id="1916" /> </Outputs> <Properties> <displayName>EGF-induced dimerization of ligand-responsive EGFR mutants</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="1917" points="844 290, 895 322" position="869 306" lineWidth="0.5" lineColor="255 51 51"> <Inputs> <Input id="1916" /> </Inputs> <Outputs> <Output id="1450" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="1918" reactomeId="1220614" points="548 385, 620 385, 700 390" position="620 385" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="1423" stoichiometry="2" /> </Inputs> <Outputs> <Output id="1919" /> </Outputs> <Properties> <displayName>Spontaneous dimerization of ligand-responsive EGFR mutants</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="1920" points="828 378, 863 369" position="845 373" lineWidth="0.5" lineColor="255 51 51"> <Inputs> <Input id="1919" /> </Inputs> <Outputs> <Output id="1450" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="1932" reactomeId="1225978" points="1038 433, 1055 395, 1106 391" position="1055 395" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="2306" points="919 216, 1005 302" /> <Input id="1584" stoichiometry="2" points="920 603" /> </Inputs> <Outputs> <Output id="1933" /> </Outputs> <Properties> <displayName>Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1940" interactionType="Activate" points="2508 327, 2500 533" position="2504 430" lineWidth="2.0"> <Inputs> <Input id="43" /> </Inputs> <Outputs> <Output id="1939" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1947" reactomeId="6785705" points="1387 239, 1220 335, 1091 327" position="1220 335" lineWidth="1.0"> <Inputs> <Input id="2318" stoichiometry="12" points="1235 548" /> <Input id="2312" points="1400 213" /> </Inputs> <Outputs> <Output id="2306" points="931 216" /> <Output id="1950" stoichiometry="12" points="1061 353" /> </Outputs> <Catalysts> <Catalyst id="1941" points="1205 295" /> </Catalysts> <Properties> <displayName>PTPRK dephosphorylates p-6Y-EGFR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1995" reactomeId="8864029" points="1351 867, 1348 867, 1364 933" position="1348 867" lineWidth="1.0"> <Inputs> <Input id="72" points="1417 462" /> <Input id="2337" stoichiometry="2" points="1310 814" /> </Inputs> <Outputs> <Output id="1997" points="1471 557, 1427 899" /> <Output id="2000" stoichiometry="2" points="1331 988" /> </Outputs> <Catalysts> <Catalyst id="1998" points="1292 911" /> </Catalysts> <Properties> <displayName>PTPN12 dephosphorylates EGFR at Y1172 (Y1148)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2043" reactomeId="8867044" points="3008 422, 3052 419, 3112 402" position="3052 419" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="23" points="3034 662" /> <Input id="81" points="2967 419" /> <Input id="76" points="2959 485" /> <Input id="108" points="3064 480" /> <Input id="581" points="3001 396" /> </Inputs> <Outputs> <Output id="2044" /> </Outputs> <Properties> <displayName>EGFR binds EPS15, EPN1, EPS15L1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2045" reactomeId="8867041" points="3316 372, 3345 383, 3371 402" position="3345 383" lineWidth="1.0"> <Inputs> <Input id="2044" points="3245 379" /> <Input id="2046" points="3310 344" /> </Inputs> <Outputs> <Output id="2047" points="3375 467" /> <Output id="2048" points="3409 425" /> </Outputs> <Catalysts> <Catalyst id="2044" points="3245 399, 3311 415" /> </Catalysts> <Properties> <displayName>EGFR phosphorylates EPS15</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2049" reactomeId="8867042" points="3382 581, 3381 601, 3384 629" position="3381 601" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2047" points="3380 563" /> <Input id="44" points="3287 644" /> <Input id="61" points="3322 588" /> </Inputs> <Outputs> <Output id="2050" /> </Outputs> <Properties> <displayName>Activated EGFR binds clathrin and AP-2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2051" reactomeId="8867047" points="3261 507, 3237 498, 3206 484" position="3237 498" lineWidth="1.0"> <Inputs> <Input id="2052" points="3278 529" /> <Input id="2047" points="3316 510" /> </Inputs> <Outputs> <Output id="2044" points="3191 435" /> <Output id="2055" points="3165 478" /> </Outputs> <Catalysts> <Catalyst id="2053" points="3268 471" /> </Catalysts> <Properties> <displayName>PTPN3 dephosphorylates EPS15</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2257" reactomeId="8951490" points="2391 461, 2423 639, 2757 635" position="2423 639" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="2151" /> </Inputs> <Outputs> <Output id="109" points="2730 518" /> <Output id="2080" points="2800 594" /> </Outputs> <Properties> <displayName>CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2286" reactomeId="179467" points="359 1249, 364 1285, 407 1289" position="364 1285" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="69" points="701 1151" /> <Input id="125" points="171 1314" /> </Inputs> <Outputs> <Output id="2287" /> </Outputs> <Properties> <displayName>GAB1 binds phosphatidylinositol-3,4,5-trisphosphate</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="2291" points="760 1136, 925 1091" position="842 1113" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="69" /> </Inputs> <Outputs> <Output id="2290" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="2292" points="490 1275, 938 1103" position="714 1189" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="2287" /> </Inputs> <Outputs> <Output id="2290" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="2300" points="339 136, 367 136" position="353 136" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="133" /> </Inputs> <Outputs> <Output id="2299" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="2341" reactomeId="1248677" points="211 296, 210 322, 207 377" position="210 322" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="2342" points="108 157" /> <Input id="1898" points="352 236" /> </Inputs> <Outputs> <Output id="2343" /> </Outputs> <Properties> <displayName>Inactivation of over-expressed wild type EGFR by Cetuximab recombinant antibody</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2344" reactomeId="9674531" points="400 461, 372 453, 333 448" position="372 453" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2345" points="462 574" /> <Input id="1898" points="416 240" /> </Inputs> <Outputs> <Output id="2346" /> </Outputs> <Properties> <displayName>AAMP binds EGFR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2367" reactomeId="9851407" points="432 294, 427 323, 396 311" position="427 323" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1898" points="422 240" /> <Input id="2368" points="446 285" /> </Inputs> <Outputs> <Output id="2369" /> </Outputs> <Properties> <displayName>FAM83B, (FAM83A, FAM83D) bind EGFR</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Signaling by EGFR, Signaling by EGFRvIII in Cancer, Signaling by Ligand-Responsive EGFR Variants in Cancer, and Signaling by Overexpressed Wild-Type EGFR in Cancer (507988)
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