Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person UniProt:P23560 BDNF

Class:Id	ReferenceGeneProduct:50786
_chainChangeLog	signal peptide:1-18 added on Fri February 6 2015;propeptide:19-128 added on Fri February 6 2015;chain:129-247 added on Fri February 6 2015;chain:19-247 for 50786 added on Fri August 9 2019
_displayName	UniProt:P23560 BDNF
_timestamp	2025-02-21 19:04:44
chain	signal peptide:1-18 chain:19-247 propeptide:19-128 chain:129-247
checksum	0A60488254722A99
comment	FUNCTION Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:11152678). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.FUNCTION Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2 (PubMed:24908487, PubMed:29909994). Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse (By similarity).SUBUNIT Monomers and homodimers. Binds to NTRK2/TRKB (PubMed:11152678, PubMed:8527932). Can form heterodimers with other neurotrophin family members, such as NTF3 and NTF4 (in vitro), but the physiological relevance of this is not clear (PubMed:10631974, PubMed:7703225). BDNF precursor form: interacts with the heterodimer formed by NGFR and SORCS2 (PubMed:24908487).INTERACTION A proportion of BDNF is secreted as immature precursor (proBDNF).ALTERNATIVE PRODUCTS 2 types of transcripts are produced: non-coding transcripts (antisense, opposite strand (OS), 8 exons) and coding transcripts (11 exons). Brain BDNF and anti-BDNF transcripts form dsRNA duplexes.TISSUE SPECIFICITY Detected in blood plasma and in saliva (at protein level) (PubMed:11152678, PubMed:19467646). Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta.PTM N-glycosylated and glycosulfated, contrary to mature BDNF.PTM Mature BDNF is produced by proteolytic removal of the propeptide, catalyzed by a FURIN family member. In addition, the precursor form is proteolytically cleaved within the propeptide, but this is not an obligatory intermediate for the production of mature BDNF (PubMed:11152678). Can be converted into mature BDNF by plasmin (PLG) (PubMed:19467646).SIMILARITY Belongs to the NGF-beta family.ONLINE INFORMATION BDNF entry
description	recommendedName: fullName evidence="25"Neurotrophic factor BDNF precursor form shortName: proBDNF alternativeName: Abrineurin alternativeName: Brain-derived neurotrophic factor component recommendedName: Neurotrophic factor BDNF /component
geneName	BDNF
identifier	P23560
isSequenceChanged	FALSE
keyword	3D-structure Alternative promoter usage Alternative splicing Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Glycoprotein Growth factor Proteomics identification Reference proteome Secreted Signal
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	BDNF
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8993486] ENSEMBL:ENSG00000176697 BDNF [Homo sapiens]
secondaryIdentifier	BDNF_HUMAN A7LA85 A7LA92 D3DQZ2 Q598Q1 Q6DN19 Q6YNR2 Q6YNR3 Q9BYY7 Q9UC24
sequenceLength	247
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:436221] UniProt:P23560-1 BDNF [Homo sapiens] [ReferenceIsoform:436222] UniProt:P23560-2 BDNF [Homo sapiens] [ReferenceIsoform:8966464] UniProt:P23560-3 BDNF [Homo sapiens] [ReferenceIsoform:8966465] UniProt:P23560-4 BDNF [Homo sapiens] [ReferenceIsoform:8966466] UniProt:P23560-5 BDNF [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:166466] BDNF [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:166527] BDNF [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:167028] BDNF [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:187013] BDNF(19-247) [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:187027] BDNF(19-247) [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:187038] BDNF(19-247) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:187041] BDNF(1-247) [endoplasmic reticulum lumen] [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by UniProt:P23560 BDNF (50786)