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Details on Person UniProt:Q92843 BCL2L2
| Class:Id | ReferenceGeneProduct:50770 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-193 added on Fri February 6 2015;initiator methionine:1 for 50770 removed on Fri Nov 03 2023;initiator methionine: for 50770 added on Fri Nov 03 2023;initiator methionine: for 50770 removed on Fri Aug 15 2025;initiator methionine:1 for 50770 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q92843 BCL2L2 |
| _timestamp | 2025-08-15 21:43:35 |
| chain | initiator methionine:1 chain:2-193 |
| checksum | 3542243A532B1762 |
| comment | FUNCTION Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.SUBUNIT Interacts with HIF3A (via C-terminus domain). Interacts with BOP.INTERACTION Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.ALTERNATIVE PRODUCTS Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines.DOMAIN The BH4 motif seems to be involved in the anti-apoptotic function.DOMAIN The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. The C-terminal residues of BCL2L2 fold into the BH3-binding cleft and modulate pro-survival activity by regulating ligand access. When BH3 domain-containing proteins bind, they displace the C-terminus, allowing its insertion into the membrane and neutralizing the pro-survival activity of BCL2L2.MISCELLANEOUS Based on a readthrough transcript which may produce a BCL2L2-PABPN1 fusion protein.SIMILARITY Belongs to the Bcl-2 family.SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: Bcl-2-like protein 2 shortName: Bcl2-L-2 alternativeName: Apoptosis regulator Bcl-W |
| geneName | BCL2L2 BCLW KIAA0271 |
| identifier | Q92843 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Apoptosis Membrane Methylation Mitochondrion Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | BCL2L2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003983] ENSEMBL:ENSG00000129473 BCL2L2 [Homo sapiens] [ReferenceDNASequence:9003984] ENSEMBL:ENSG00000258643 BCL2L2 [Homo sapiens] |
| secondaryIdentifier | B2CL2_HUMAN A8K0F4 Q2M3U0 Q5U0H4 |
| sequenceLength | 193 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8972709] UniProt:Q92843-1 BCL2L2 [Homo sapiens] [ReferenceIsoform:8972710] UniProt:Q92843-2 BCL2L2 [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q92843 BCL2L2 (50770)
