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Details on Person UniProt:O00512 BCL9
| Class:Id | ReferenceGeneProduct:50764 |
|---|---|
| _chainChangeLog | chain:1-1426 added on Fri February 6 2015 |
| _displayName | UniProt:O00512 BCL9 |
| _timestamp | 2024-11-03 20:18:06 |
| chain | chain:1-1426 |
| checksum | 51EF3D0DCA2103CB |
| comment | FUNCTION Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity).SUBUNIT Binds to beta-catenin (CTNNB1), PYGO1 and PYGO2; the interaction with PYGO1 increases PYGO1 affinity to histone H3 methylated at 'Lys 4'.INTERACTION Detected at low levels in thymus, prostate, testis, ovary and small intestine, and at lower levels in spleen, colon and blood.DISEASE A chromosomal aberration involving BCL9 is found in a patient with precursor B-cell acute lymphoblastic leukemia (ALL). Translocation t(1;14)(q21;q32). This translocation leaves the coding region intact, but may have pathogenic effects due to alterations in the expression level of BCL9. Several cases of translocations within the 3'-UTR of BCL9 have been found in B-cell malignancies.SIMILARITY Belongs to the BCL9 family.CAUTION It is uncertain whether Met-1 or Met-27 is the initiator. |
| description | recommendedName: B-cell CLL/lymphoma 9 protein shortName: B-cell lymphoma 9 protein shortName: Bcl-9 alternativeName: Protein legless homolog |
| geneName | BCL9 |
| identifier | O00512 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Chromosomal rearrangement Methylation Nucleus Phosphoprotein Proteomics identification Proto-oncogene Reference proteome Wnt signaling pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | BCL9 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999342] ENSEMBL:ENSG00000116128 BCL9 [Homo sapiens] |
| secondaryIdentifier | BCL9_HUMAN Q5T489 |
| sequenceLength | 1426 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:201714] BCL9 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O00512 BCL9 (50764)
