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Details on Person UniProt:P56945 BCAR1
| Class:Id | ReferenceGeneProduct:50744 |
|---|---|
| _chainChangeLog | chain:1-870 added on Sat February 7 2015 |
| _displayName | UniProt:P56945 BCAR1 |
| _timestamp | 2025-02-21 19:04:40 |
| chain | chain:1-870 |
| checksum | B81EC3430049E795 |
| comment | FUNCTION Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity).SUBUNIT Forms complexes in vivo with PTK2/FAK1, adapter protein CRKL and LYN kinase (PubMed:9020138). Heterodimerizes with NEDD9 (PubMed:10502414). Component of a complex comprised of SH2D3C, BCAR1/CAS, and CRK (PubMed:12432078). Within the complex, interacts with SH2D3C (via C-terminus), and CRK (PubMed:12432078, PubMed:17174122). Part of a complex comprised of PTPRA, BCAR1, BCAR3 (via SH2 domain) and SRC; the formation of the complex is dependent on integrin mediated-tyrosine phosphorylation of PTPRA (PubMed:22801373). Interacts with BCAR3 (via Ras-GEF domain); the interaction regulates adhesion-dependent serine phosphorylation (PubMed:22081014). Interacts with SMAD2 and SMAD3 (By similarity). Interacts with NPHP1 (By similarity). Interacts with PTK2B/PYK2 (PubMed:19086031, PubMed:9020138). Interacts (via C-terminus) with SH2D3C/CHAT isoform 2 (via C-terminus) (PubMed:17174122, PubMed:22081014). Interacts with activated CSPG4. Interacts with BMX, INPPL1/SHIP2 and PEAK1. Part of a collagen-stimulated complex involved in cell migration made of CDC42, CRK, TNK2 and BCAR1/p130cas. Interacts with TNK2 via SH3 domains. Interacts (when tyrosine-phosphorylated) with tensin TNS1; the interaction is increased by phosphorylation of TNS1 (PubMed:20798394).INTERACTION Unphosphorylated form localizes in the cytoplasm (By similarity). Localizes to focal adhesion sites following integrin engagement (By similarity).ALTERNATIVE PRODUCTS Expressed in B-cells (at protein level) (PubMed:9020138). Widely expressed with an abundant expression in the testis (PubMed:10639512). Low level of expression seen in the liver, thymus, and peripheral blood leukocytes (PubMed:10639512).DOMAIN Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL1 SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with NEDD9 (By similarity).DOMAIN A serine-rich region promotes activation of the serum response element (SRE).DOMAIN The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one proline-rich region of PTK2/FAK11.PTM PTK2/FAK1 activation mediates phosphorylation at the YDYVHL motif; phosphorylation is most likely catalyzed by SRC family members. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin-mediated adhesion of cells to the extracellular matrix.PTM Dephosphorylated by PTPN14 at Tyr-128.PTM Phosphorylated by SRC kinase in a EDN1- and PTK2B-mediated manner; phosphorylation strengthens its interaction with BCAR3 as part of the PTK2B/BCAR1/BCAR3/RAP1 signaling pathway.SIMILARITY Belongs to the CAS family. |
| description | recommendedName: Breast cancer anti-estrogen resistance protein 1 alternativeName: CRK-associated substrate alternativeName: Cas scaffolding protein family member 1 alternativeName: p130cas |
| geneName | BCAR1 CAS CASS1 CRKAS |
| identifier | P56945 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cell adhesion Cell junction Cell projection Cytoplasm Diabetes mellitus Direct protein sequencing Phosphoprotein Proteomics identification Reference proteome SH3 domain SH3-binding |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | BCAR1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003401] ENSEMBL:ENSG00000050820 BCAR1 [Homo sapiens] |
| secondaryIdentifier | BCAR1_HUMAN B3KWD7 B4DEV4 B4DGB5 B4DIW5 B7Z7X7 E9PCL5 E9PCV2 F5GXA2 F5GXV6 F5H7Z0 F8WA69 Q6QEF7 |
| sequenceLength | 870 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8975900] UniProt:P56945-1 BCAR1 [Homo sapiens] [ReferenceIsoform:8975901] UniProt:P56945-2 BCAR1 [Homo sapiens] [ReferenceIsoform:8975902] UniProt:P56945-3 BCAR1 [Homo sapiens] [ReferenceIsoform:8975903] UniProt:P56945-4 BCAR1 [Homo sapiens] [ReferenceIsoform:8975904] UniProt:P56945-5 BCAR1 [Homo sapiens] [ReferenceIsoform:8975905] UniProt:P56945-6 BCAR1 [Homo sapiens] [ReferenceIsoform:8975906] UniProt:P56945-7 BCAR1 [Homo sapiens] [ReferenceIsoform:8975907] UniProt:P56945-8 BCAR1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:201625] BCAR1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:372645] p-Y-BCAR1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5218739] p-Y12-BCAR1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8848723] p-Y165,Y664-BCAR1 [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:372648] O4'-phospho-L-tyrosine at unknown position [ModifiedResidue:5218692] O4'-phospho-L-tyrosine at 410 [ModifiedResidue:5218696] O4'-phospho-L-tyrosine at 249 [ModifiedResidue:5218701] O4'-phospho-L-tyrosine at 327 [ModifiedResidue:5218709] O4'-phospho-L-tyrosine at 362 [ModifiedResidue:5218710] O4'-phospho-L-tyrosine at 664 [ModifiedResidue:5218712] O4'-phospho-L-tyrosine at 372 [ModifiedResidue:5218715] O4'-phospho-L-tyrosine at 666 [ModifiedResidue:5218717] O4'-phospho-L-tyrosine at 287 [ModifiedResidue:5218733] O4'-phospho-L-tyrosine at 234 |
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No pathways have been reviewed or authored by UniProt:P56945 BCAR1 (50744)
