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Details on Person UniProt:O95870 ABHD16A
| Class:Id | ReferenceGeneProduct:50711 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-558 added on Fri February 6 2015;initiator methionine:1 removed on Fri November 4 2016;chain:2-558 removed on Fri November 4 2016;chain:1-558 added on Fri November 4 2016 |
| _displayName | UniProt:O95870 ABHD16A |
| _timestamp | 2025-02-21 19:35:09 |
| chain | chain:1-558 |
| checksum | BC46EDA0725D44EA |
| comment | FUNCTION Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (PubMed:25290914). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) (PubMed:25290914).CATALYTIC ACTIVITY 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphoserine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)CATALYTIC ACTIVITY 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + (9Z)-octadecenoate + H(+)CATALYTIC ACTIVITY 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoserine + (9Z,12Z)-octadecadienoate + H(+)CATALYTIC ACTIVITY 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)CATALYTIC ACTIVITY 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoglycerol + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoglycerol + (9Z)-octadecenoate + H(+)CATALYTIC ACTIVITY 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z)-octadecenoate + H(+)CATALYTIC ACTIVITY 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)CATALYTIC ACTIVITY 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)CATALYTIC ACTIVITY Hydrolyzes glycerol monoesters of long-chain fatty acids.CATALYTIC ACTIVITY 1-tetradecanoylglycerol + H2O = tetradecanoate + glycerol + H(+)CATALYTIC ACTIVITY 2-hexadecanoylglycerol + H2O = glycerol + hexadecanoate + H(+)CATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)CATALYTIC ACTIVITY 2-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)CATALYTIC ACTIVITY 2-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)CATALYTIC ACTIVITY 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)CATALYTIC ACTIVITY 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)CATALYTIC ACTIVITY prostaglandin D2-1-glycerol ester + H2O = prostaglandin D2 + glycerol + H(+)CATALYTIC ACTIVITY 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 + H2O = 15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+)CATALYTIC ACTIVITY 1-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)ACTIVITY REGULATION Inhibited by beta-lactone-based lipid inhibitors, such as beta-lactone palmostatin-B.BIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 7.2-8.0.INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the AB hydrolase superfamily. ABHD16 family. |
| description | recommendedName: fullName evidence="10"Phosphatidylserine lipase ABHD16A ecNumber evidence="2"3.1.-.- alternativeName: fullName evidence="10"Alpha/beta hydrolase domain-containing protein 16A shortName evidence="10"Abhydrolase domain-containing protein 16A alternativeName: fullName evidence="9"HLA-B-associated transcript 5 shortName evidence="9"hBAT5 alternativeName: fullName evidence="10"Monoacylglycerol lipase ABHD16A ecNumber evidence="4"3.1.1.23 alternativeName: Protein G5 |
| geneName | ABHD16A BAT5 G5 NG26 PP199 |
| identifier | O95870 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Direct protein sequencing Disease variant Hereditary spastic paraplegia Hydrolase Lipid metabolism Membrane Neurodegeneration Proteomics identification Reference proteome Transmembrane Transmembrane helix |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2455454] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8869714] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9819394] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | ABHD16A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962497] ENSEMBL:ENSG00000204427 ABHD16A [Homo sapiens] |
| secondaryIdentifier | ABHGA_HUMAN A2BEY3 B7Z4R6 Q5SRR1 Q5SRR2 Q8WYH0 Q9NW33 |
| sequenceLength | 558 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8965953] UniProt:O95870-1 ABHD16A [Homo sapiens] [ReferenceIsoform:8965954] UniProt:O95870-2 ABHD16A [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O95870 ABHD16A (50711)
