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Details on Person UniProt:Q16611 BAK1

Class:Id	ReferenceGeneProduct:50691
_chainChangeLog	initiator methionine:1 added on Fri February 6 2015;chain:2-211 added on Fri February 6 2015;initiator methionine:1 for 50691 removed on Fri Nov 03 2023;initiator methionine: for 50691 added on Fri Nov 03 2023;initiator methionine: for 50691 removed on Fri Aug 15 2025;initiator methionine:1 for 50691 added on Fri Aug 15 2025
_displayName	UniProt:Q16611 BAK1
_timestamp	2025-08-15 21:59:02
chain	initiator methionine:1 chain:2-211
checksum	A2200FE72A46D04E
comment	FUNCTION Plays a role in the mitochondrial apoptotic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases.SUBUNIT Homodimer. Formation of the homodimer is zinc-dependent (PubMed:17157251). Forms heterodimers with BCL2 and BCL2L1 isoform Bcl-X(L) (PubMed:9020082). Forms heterooligomers with BAX (PubMed:29531808). Interacts with BCL2A1 (By similarity). Interacts with RTL10/BOP (PubMed:23055042). Interacts with VDAC1 (PubMed:25296756). Interacts with GIMAP3/IAN4 and GIMAP5/IAN5 (PubMed:16509771).SUBUNIT (Microbial infection) Interacts with vaccinia virus protein F1.SUBUNIT (Microbial infection) Interacts with myxoma virus protein M11L.SUBUNIT (Microbial infection) Interacts with Epstein-Barr virus protein BALF1.SUBUNIT (Microbial infection) Interacts with adenovirus protein E1B 19K.INTERACTION Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.DOMAIN Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.SIMILARITY Belongs to the Bcl-2 family.
description	recommendedName: Bcl-2 homologous antagonist/killer alternativeName: Apoptosis regulator BAK alternativeName: Bcl-2-like protein 7 shortName: Bcl2-L-7
geneName	BAK1 BAK BCL2L7 CDN1
identifier	Q16611
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative splicing Apoptosis Host-virus interaction Membrane Metal-binding Mitochondrion Mitochondrion outer membrane Proteomics identification Reference proteome Transmembrane Transmembrane helix Zinc
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
name	BAK1
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8987693] ENSEMBL:ENSG00000030110 BAK1 [Homo sapiens]
secondaryIdentifier	BAK_HUMAN C0H5Y7 Q6I9T6 Q92533
sequenceLength	211
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:8969099] UniProt:Q16611-1 BAK1 [Homo sapiens] [ReferenceIsoform:8969100] UniProt:Q16611-2 BAK1 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:50690] BAK1 activated [mitochondrial outer membrane] [Homo sapiens] [EntityWithAccessionedSequence:139896] BAK1 [mitochondrial outer membrane] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q16611 BAK1 (50691)