Query author contributions in Reactome
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Details on Person UniProt:O95429 BAG4
| Class:Id | ReferenceGeneProduct:50677 |
|---|---|
| _chainChangeLog | chain:1-457 added on Fri February 6 2015 |
| _displayName | UniProt:O95429 BAG4 |
| _timestamp | 2024-11-03 20:13:24 |
| chain | chain:1-457 |
| checksum | B89D59E8118684A3 |
| comment | FUNCTION Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria.SUBUNIT Binds to the ATPase domain of HSP/HSC70 chaperones. Binds to the death domain of TNFRSF1A in the absence of TNF and thereby prevents binding of adapter molecules such as TRADD or TRAF2. Binds to the death domain of TNFRSF12. Interacts with PRKN.INTERACTION Ubiquitous. |
| description | recommendedName: BAG family molecular chaperone regulator 4 shortName: BAG-4 alternativeName: Bcl-2-associated athanogene 4 alternativeName: Silencer of death domains |
| geneName | BAG4 SODD |
| identifier | O95429 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Chaperone Cytoplasm Methylation Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | BAG4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001034] ENSEMBL:ENSG00000156735 BAG4 [Homo sapiens] |
| secondaryIdentifier | BAG4_HUMAN B4E217 O95818 |
| sequenceLength | 457 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8971347] UniProt:O95429-1 BAG4 [Homo sapiens] [ReferenceIsoform:8971348] UniProt:O95429-2 BAG4 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:5212670] BAG4 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8853156] BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8853157] BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O95429 BAG4 (50677)
