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Details on Person UniProt:Q92934 BAD
| Class:Id | ReferenceGeneProduct:50663 |
|---|---|
| _chainChangeLog | chain:1-168 added on Fri February 6 2015 |
| _displayName | UniProt:Q92934 BAD |
| _timestamp | 2024-11-03 19:59:51 |
| chain | chain:1-168 |
| checksum | 69FD8D27DDEE3241 |
| comment | FUNCTION Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.SUBUNIT Forms heterodimers with the anti-apoptotic proteins, Bcl-X(L), Bcl-2 and Bcl-W. Also binds protein S100A10 (By similarity). The Ser-75/Ser-99 phosphorylated form binds 14-3-3 proteins (By similarity). Interacts with AKT1 and PIM3. Interacts (via BH3 domain) with NOL3 (via CARD domain); preventing the association of BAD with BCL2 (By similarity). Interacts with HIF3A (via C-terminus domain); the interaction reduces the binding between BAD and BAX (By similarity). Interacts with GIMAP3/IAN4 and GIMAP5/IAN5 (PubMed:16509771).INTERACTION Colocalizes with HIF3A in the cytoplasm (By similarity). Upon phosphorylation, locates to the cytoplasm.TISSUE SPECIFICITY Expressed in a wide variety of tissues.DOMAIN Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.PTM Phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks its pro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the release of Bcl-X(L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation. Phosphorylation at Ser-99 by PKB/AKT1 is almost completely blocked by the apoptotic C-terminus cleavage product of PKN2 generated by caspases-3 activity during apoptosis.PTM Methylation at Arg-94 and Arg-96 by PRMT1 inhibits Akt-mediated phosphorylation at Ser-99.SIMILARITY Belongs to the Bcl-2 family.CAUTION The protein name 'Bcl2 antagonist of cell death' may be misleading. The protein antagonises Bcl2-mediated repression of cell death, hence it promotes apoptosis.SEQUENCE CAUTION Bcl 2-associated death promoter entry |
| description | recommendedName: Bcl2-associated agonist of cell death shortName: BAD alternativeName: Bcl-2-binding component 6 alternativeName: Bcl-2-like protein 8 shortName: Bcl2-L-8 alternativeName: Bcl-xL/Bcl-2-associated death promoter alternativeName: Bcl2 antagonist of cell death |
| geneName | BAD BBC6 BCL2L8 |
| identifier | Q92934 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Apoptosis Cytoplasm Membrane Methylation Mitochondrion Mitochondrion outer membrane Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | BAD |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003987] ENSEMBL:ENSG00000002330 BAD [Homo sapiens] |
| secondaryIdentifier | BAD_HUMAN O14803 Q6FH21 |
| sequenceLength | 168 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:50662] BAD [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:114242] BAD [mitochondrial outer membrane] [Homo sapiens] [EntityWithAccessionedSequence:139901] p-BAD [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:198335] p-S99-BAD [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:217297] p-S91-BAD [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:139900] phosphorylated residue at unknown position [ModifiedResidue:198322] O-phospho-L-serine at 99 [ModifiedResidue:217298] O-phospho-L-serine at 91 |
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No pathways have been reviewed or authored by UniProt:Q92934 BAD (50663)
