Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person UniProt:O00154 ACOT7

Class:Id	ReferenceGeneProduct:50661
_chainChangeLog	chain:1-380 added on Fri February 6 2015
_displayName	UniProt:O00154 ACOT7
_timestamp	2025-02-21 20:06:45
chain	chain:1-380
checksum	BDD75D62A60095BC
comment	FUNCTION Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:10578051). Preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 (PubMed:10578051). May play an important physiological function in brain (PubMed:10578051).CATALYTIC ACTIVITY hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)CATALYTIC ACTIVITY octanoyl-CoA + H2O = octanoate + CoA + H(+)CATALYTIC ACTIVITY dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+)CATALYTIC ACTIVITY (9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)CATALYTIC ACTIVITY tetradecanoyl-CoA + H2O = tetradecanoate + CoA + H(+)CATALYTIC ACTIVITY decanoyl-CoA + H2O = decanoate + CoA + H(+)CATALYTIC ACTIVITY octadecanoyl-CoA + H2O = octadecanoate + CoA + H(+)PATHWAY Lipid metabolism; fatty acid metabolism.SUBUNIT Homohexamer.INTERACTION Isoform 4 is expressed exclusively in brain.DOMAIN Both HotDog ACOT-type hydrolase domains are required for efficient activity.MISCELLANEOUS Major isoform.
description	recommendedName: Cytosolic acyl coenzyme A thioester hydrolase ecNumber evidence="15"3.1.2.2 alternativeName: Acyl-CoA thioesterase 7 alternativeName: Brain acyl-CoA hydrolase shortName: BACH shortName evidence="8"hBACH alternativeName: CTE-IIa shortName: CTE-II alternativeName: Long chain acyl-CoA thioester hydrolase
geneName	ACOT7 BACH
identifier	O00154
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Fatty acid metabolism Hydrolase Lipid metabolism Mitochondrion Proteomics identification Reference proteome Repeat Serine esterase
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	ACOT7
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9001033] ENSEMBL:ENSG00000097021 ACOT7 [Homo sapiens]
secondaryIdentifier	BACH_HUMAN A8K0K7 A8K232 A8K6B8 A8K837 B3KQ12 O43703 Q53Y78 Q5JYL2 Q5JYL3 Q5JYL4 Q5JYL5 Q5JYL6 Q5TGR4 Q9UJM9 Q9Y539 Q9Y540
sequenceLength	380
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:144454] UniProt:O00154-2 ACOT7 [Homo sapiens] [ReferenceIsoform:144455] UniProt:O00154-3 ACOT7 [Homo sapiens] [ReferenceIsoform:144456] UniProt:O00154-4 ACOT7 [Homo sapiens] [ReferenceIsoform:144457] UniProt:O00154-5 ACOT7 [Homo sapiens] [ReferenceIsoform:144458] UniProt:O00154-6 ACOT7 [Homo sapiens] [ReferenceIsoform:401083] UniProt:O00154-1 ACOT7 [Homo sapiens] [ReferenceIsoform:8971346] UniProt:O00154-7 ACOT7 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:5690040] ACOT7 [cytosol] [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by UniProt:O00154 ACOT7 (50661)