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Details on Person UniProt:P61769 B2M
| Class:Id | ReferenceGeneProduct:50591 |
|---|---|
| _chainChangeLog | signal peptide:1-20 added on Sat February 7 2015;chain:21-119 added on Sat February 7 2015;chain:22-119 added on Sat February 7 2015 |
| _displayName | UniProt:P61769 B2M |
| _timestamp | 2024-11-03 19:59:51 |
| chain | signal peptide:1-20 chain:21-119 chain:22-119 |
| checksum | AFD2DBEF07DCEF27 |
| comment | FUNCTION Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).SUBUNIT Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. B2M alone (not in complex with HLA-I) interacts with M.tuberculosis EsxA (ESAT-6) and an EsxA-EsxB (CFP-10) complex; the tripartite complex can be detected in the host endoplasmic reticulum (PubMed:25356553). The B2M-EsxA complex can be detected in patients with pleural tuberculosis and is stable from pH 4.0 to 8.0 and in the presence of 2M NaCl (PubMed:25356553). Forms a heterotrimer with HLA-E and a self- or a foreign peptide (PubMed:9427624). Forms a heterotrimer with HLA-G and a self-peptide (PubMed:17056715). Forms a heterotrimer with HLA-F and a self-peptide (PubMed:10605026). Forms a heterotrimer with MR1 and a metabolite antigen.INTERACTION Detected in serum and urine (PubMed:1336137, PubMed:7554280).SUBCELLULAR LOCATION (Microbial infection) In the presence of M.tuberculosis EsxA-EsxB complex decreased amounts of B2M are found on the cell surface (PubMed:25356553).PTM Glycation of Ile-21 is observed in long-term hemodialysis patients.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry. Apart from the presence of causative mutations, beta-2-microglobulin may adopt the fibrillar configuration of amyloid, resulting in amyloidosis, when its serum levels are persistently high, as seen in patients on long-term hemodialysis (PubMed:7918443). In contrast to patients with dialysis-related amyloidosis, patients with hereditary amyloidosis have normal circulating concentrations of beta2-microglobulin (PubMed:22693999).SIMILARITY Belongs to the beta-2-microglobulin family.ONLINE INFORMATION Beta-2-microglobulin entry |
| description | recommendedName: Beta-2-microglobulin component recommendedName: Beta-2-microglobulin form pI 5.3 /component |
| geneName | B2M CDABP0092 HDCMA22P |
| identifier | P61769 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Amyloid Amyloidosis Direct protein sequencing Disease variant Disulfide bond Glycation Glycoprotein Immunity Immunoglobulin domain MHC I Proteomics identification Pyrrolidone carboxylic acid Reference proteome Secreted Signal |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8856987] Weiser, JD [InstanceEdit:8964659] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9698430] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | B2M |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962221] ENSEMBL:ENSG00000166710 B2M [Homo sapiens] |
| secondaryIdentifier | B2MG_HUMAN P01884 Q540F8 Q6IAT8 Q9UCK0 Q9UD48 Q9UDF4 |
| sequenceLength | 119 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:167743] B2M(21-119) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:182298] B2M(21-119) [early endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:983063] B2M(21-119) [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:983378] B2M(21-119) [ER to Golgi transport vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:983403] B2M(21-119) [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:1236827] B2M(21-119) [early endosome lumen] [Homo sapiens] [EntityWithAccessionedSequence:1236891] B2M(21-119) [phagocytic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:1302721] B2M(21-119) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:6800179] B2M(21-119) [tertiary granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6806144] B2M(21-119) [specific granule lumen] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P61769 B2M (50591)
