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Details on Person UniProt:Q13705 ACVR2B
| Class:Id | ReferenceGeneProduct:50577 |
|---|---|
| _chainChangeLog | signal peptide:1-18 added on Fri February 6 2015;chain:19-512 added on Fri February 6 2015 |
| _displayName | UniProt:Q13705 ACVR2B |
| _timestamp | 2025-02-21 18:44:37 |
| chain | signal peptide:1-18 chain:19-512 |
| checksum | B377FEF92EF74937 |
| comment | FUNCTION Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor.CATALYTIC ACTIVITY L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)CATALYTIC ACTIVITY L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl-[receptor-protein] + ADP + H(+)COFACTOR Forms an activin receptor complex with activin type II receptors such as ACVR1B. Interacts with VPS39. Interacts with DYNLT1. Interacts with BMP3 (PubMed:31665064). Interacts with BMP2 (PubMed:17295905). Interacts with BMP6 (PubMed:18070108).INTERACTION Phosphorylated. Constitutive phosphorylation is in part catalyzed by its own kinase activity.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Produced from the insertion in the transcript of 82 base pairs, leading to frameshift and protein truncation. May be not functional.SIMILARITY Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. |
| description | recommendedName: Activin receptor type-2B ecNumber: 2.7.11.30 alternativeName: Activin receptor type IIB shortName: ACTR-IIB |
| geneName | ACVR2B |
| identifier | Q13705 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing ATP-binding Cell membrane Disease variant Disulfide bond Glycoprotein Heterotaxy Kinase Magnesium Manganese Membrane Metal-binding Nucleotide-binding Phosphoprotein Proteomics identification Receptor Reference proteome Serine/threonine-protein kinase Signal Transferase Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | ACVR2B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989388] ENSEMBL:ENSG00000114739 ACVR2B [Homo sapiens] |
| secondaryIdentifier | AVR2B_HUMAN Q4VAV0 |
| sequenceLength | 512 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:144425] UniProt:Q13705-2 ACVR2B [Homo sapiens] [ReferenceIsoform:405654] UniProt:Q13705-1 ACVR2B [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:201656] ACVR2B [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q13705 ACVR2B (50577)
