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Details on Person UniProt:P27037 ACVR2A
| Class:Id | ReferenceGeneProduct:50575 |
|---|---|
| _chainChangeLog | signal peptide:1-19 added on Fri February 6 2015;chain:20-513 added on Fri February 6 2015 |
| _displayName | UniProt:P27037 ACVR2A |
| _timestamp | 2026-02-20 21:27:44 |
| chain | signal peptide:1-19 chain:20-513 |
| checksum | A89822E880979618 |
| comment | FUNCTION On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A (PubMed:17911401, PubMed:10652306). Mediates induction of adipogenesis by GDF6 (By similarity).CATALYTIC ACTIVITY L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)CATALYTIC ACTIVITY L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl-[receptor-protein] + ADP + H(+)COFACTOR Part of a complex consisting of MAGI2/ARIP1, ACVR2A, ACVR1B and SMAD3 (By similarity). Interacts with MAGI2/ARIP1 (By similarity). Interacts with type I receptor ACVR1 (PubMed:17911401). Interacts with BMP7 (PubMed:12667445). Interacts with TSC22D1/TSC-22 (PubMed:21791611). Interacts with activin A/INHBA (PubMed:10652306).INTERACTION Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. |
| description | recommendedName: fullName evidence="16"Activin receptor type-2A ecNumber evidence="13"2.7.11.30 alternativeName: Activin receptor type IIA shortName: ACTR-IIA shortName: ACTRIIA |
| geneName | ACVR2A ACVR2 |
| identifier | P27037 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing ATP-binding Cell membrane Disulfide bond Glycoprotein Kinase Magnesium Manganese Membrane Metal-binding Nucleotide-binding Proteomics identification Receptor Reference proteome Serine/threonine-protein kinase Signal Transferase Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | ACVR2A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992901] ENSEMBL:ENSG00000121989 ACVR2A [Homo sapiens] |
| secondaryIdentifier | AVR2A_HUMAN B2RAB8 B4DWQ2 D3DP85 Q53TH4 Q6NWV2 Q92474 |
| sequenceLength | 513 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8969562] UniProt:P27037-1 ACVR2A [Homo sapiens] [ReferenceIsoform:8969563] UniProt:P27037-2 ACVR2A [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:201659] ACVR2A [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P27037 ACVR2A (50575)
