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Details on Person UniProt:O75947 ATP5PD
| Class:Id | ReferenceGeneProduct:50523 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-161 added on Fri February 6 2015;initiator methionine:1 for 50523 removed on Fri Nov 03 2023;initiator methionine: for 50523 added on Fri Nov 03 2023;initiator methionine: for 50523 removed on Fri Aug 15 2025;initiator methionine:1 for 50523 added on Fri Aug 15 2025 |
| _displayName | UniProt:O75947 ATP5PD |
| _timestamp | 2026-02-20 21:27:40 |
| chain | initiator methionine:1 chain:2-161 |
| checksum | E93020ADA1BA1694 |
| comment | FUNCTION Subunit d, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (PubMed:37244256). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity).SUBUNIT Component of the ATP synthase complex composed at least of ATP5F1A/subunit alpha, ATP5F1B/subunit beta, ATP5MC1/subunit c (homooctamer), MT-ATP6/subunit a, MT-ATP8/subunit 8, ATP5ME/subunit e, ATP5MF/subunit f, ATP5MG/subunit g, ATP5MK/subunit k, ATP5MJ/subunit j, ATP5F1C/subunit gamma, ATP5F1D/subunit delta, ATP5F1E/subunit epsilon, ATP5PF/subunit F6, ATP5PB/subunit b, ATP5PD/subunit d, ATP5PO/subunit OSCP (PubMed:37244256). ATP synthase complex consists of a soluble F(1) head domain (subunits alpha(3) and beta(3)) - the catalytic core - and a membrane F(0) domain - the membrane proton channel (subunits c, a, 8, e, f, g, k and j) (PubMed:37244256). These two domains are linked by a central stalk (subunits gamma, delta, and epsilon) rotating inside the F1 region and a stationary peripheral stalk (subunits F6, b, d, and OSCP) (PubMed:37244256). Interacts with FLVCR2; this interaction occurs in the absence of heme and is disrupted upon heme binding (By similarity).INTERACTION Belongs to the ATPase d subunit family. |
| description | recommendedName: fullName evidence="7"ATP synthase peripheral stalk subunit d, mitochondrial shortName: ATPase subunit d alternativeName: fullName evidence="7"ATP synthase peripheral stalk subunit d |
| geneName | ATP5PD ATP5H My032 |
| identifier | O75947 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing CF(0) Direct protein sequencing Hydrogen ion transport Ion transport Membrane Mitochondrion Mitochondrion inner membrane Proteomics identification Reference proteome Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | ATP5PD |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998753] ENSEMBL:ENSG00000167863 ATP5PD [Homo sapiens] |
| secondaryIdentifier | ATP5H_HUMAN B2R5L6 Q9H3J4 |
| sequenceLength | 161 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:144370] UniProt:O75947-2 ATP5PD [Homo sapiens] [ReferenceIsoform:401912] UniProt:O75947-1 ATP5PD [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:50522] ATP5PD [mitochondrial inner membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O75947 ATP5PD (50523)
