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Details on Person UniProt:P56134 ATP5MF
| Class:Id | ReferenceGeneProduct:50517 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-94 added on Fri February 6 2015;initiator methionine:1 for 50517 removed on Fri Nov 03 2023;initiator methionine: for 50517 added on Fri Nov 03 2023;initiator methionine: for 50517 removed on Fri Aug 15 2025;initiator methionine:1 for 50517 added on Fri Aug 15 2025 |
| _displayName | UniProt:P56134 ATP5MF |
| _timestamp | 2026-02-20 23:03:23 |
| chain | initiator methionine:1 chain:2-94 |
| checksum | D5F0D94273DEF880 |
| comment | FUNCTION Subunit f, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (PubMed:37244256).SUBUNIT Component of the ATP synthase complex composed at least of ATP5F1A/subunit alpha, ATP5F1B/subunit beta, ATP5MC1/subunit c (homooctamer), MT-ATP6/subunit a, MT-ATP8/subunit 8, ATP5ME/subunit e, ATP5MF/subunit f, ATP5MG/subunit g, ATP5MK/subunit k, ATP5MJ/subunit j, ATP5F1C/subunit gamma, ATP5F1D/subunit delta, ATP5F1E/subunit epsilon, ATP5PF/subunit F6, ATP5PB/subunit b, ATP5PD/subunit d, ATP5PO/subunit OSCP (PubMed:37244256). ATP synthase complex consists of a soluble F(1) head domain (subunits alpha(3) and beta(3)) - the catalytic core - and a membrane F(0) domain - the membrane proton channel (subunits c, a, 8, e, f, g, k and j) (PubMed:37244256). These two domains are linked by a central stalk (subunits gamma, delta, and epsilon) rotating inside the F1 region and a stationary peripheral stalk (subunits F6, b, d, and OSCP) (PubMed:37244256).SUBCELLULAR LOCATION Belongs to the ATPase F chain family. |
| description | recommendedName: fullName evidence="6"ATP synthase F(0) complex subunit f, mitochondrial alternativeName: fullName evidence="6"ATP synthase membrane subunit f |
| geneName | ATP5MF ATP5J2 ATP5JL |
| identifier | P56134 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing ATP synthesis CF(0) Hydrogen ion transport Ion transport Membrane Mitochondrion Mitochondrion inner membrane Phosphoprotein Proteomics identification Reference proteome Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | ATP5MF |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990553] ENSEMBL:ENSG00000241468 ATP5MF [Homo sapiens] |
| secondaryIdentifier | ATPK_HUMAN C9J8H9 F8W7V3 O76079 Q6IBB3 Q96L83 Q9BTI8 |
| sequenceLength | 94 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:144367] UniProt:P56134-2 ATP5MF [Homo sapiens] [ReferenceIsoform:404461] UniProt:P56134-1 ATP5MF [Homo sapiens] [ReferenceIsoform:8972302] UniProt:P56134-3 ATP5MF [Homo sapiens] [ReferenceIsoform:8972303] UniProt:P56134-4 ATP5MF [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:50516] ATP5MF [mitochondrial inner membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P56134 ATP5MF (50517)
