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Details on Person UniProt:P56381 ATP5F1E
| Class:Id | ReferenceGeneProduct:50509 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-51 added on Fri February 6 2015 |
| _displayName | UniProt:P56381 ATP5F1E |
| _timestamp | 2026-02-20 21:27:39 |
| chain | chain:1-51 |
| checksum | C3E8FDA7C9191CA4 |
| comment | FUNCTION Subunit epsilon, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). May be essential for the assembly of F(1) and may play an important role in the incorporation of the hydrophobic subunit c into the F(1)-c oligomer rotor of the mitochondrial ATP synthase complex (PubMed:20026007).SUBUNIT Component of the ATP synthase complex composed at least of ATP5F1A/subunit alpha, ATP5F1B/subunit beta, ATP5MC1/subunit c (homooctamer), MT-ATP6/subunit a, MT-ATP8/subunit 8, ATP5ME/subunit e, ATP5MF/subunit f, ATP5MG/subunit g, ATP5MK/subunit k, ATP5MJ/subunit j, ATP5F1C/subunit gamma, ATP5F1D/subunit delta, ATP5F1E/subunit epsilon, ATP5PF/subunit F6, ATP5PB/subunit b, ATP5PD/subunit d, ATP5PO/subunit OSCP (PubMed:37244256). ATP synthase complex consists of a soluble F(1) head domain (subunits alpha(3) and beta(3)) - the catalytic core - and a membrane F(0) domain - the membrane proton channel (subunits c, a, 8, e, f, g, k and j) (PubMed:37244256). These two domains are linked by a central stalk (subunits gamma, delta, and epsilon) rotating inside the F1 region and a stationary peripheral stalk (subunits F6, b, d, and OSCP) (PubMed:37244256).INTERACTION Ubiquitous.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the eukaryotic ATPase epsilon family. |
| description | recommendedName: fullName evidence="7"ATP synthase F(1) complex subunit epsilon, mitochondrial shortName: ATPase subunit epsilon alternativeName: fullName evidence="9"ATP synthase F1 subunit epsilon |
| geneName | ATP5F1E ATP5E |
| identifier | P56381 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation ATP synthesis CF(1) Disease variant Hydrogen ion transport Hydrolase Ion transport Membrane Mitochondrion Mitochondrion inner membrane Primary mitochondrial disease Proteomics identification Reference proteome Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | ATP5F1E |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988834] ENSEMBL:ENSG00000124172 ATP5F1E [Homo sapiens] |
| secondaryIdentifier | ATP5E_HUMAN B2RDD0 E1P5H6 Q53XU6 |
| sequenceLength | 51 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:50508] ATP5F1E [mitochondrial matrix] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P56381 ATP5F1E (50509)
