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Details on Person UniProt:Q92858 ATOH1
| Class:Id | ReferenceGeneProduct:50477 |
|---|---|
| _chainChangeLog | chain:1-354 added on Fri February 6 2015 |
| _displayName | UniProt:Q92858 ATOH1 |
| _timestamp | 2024-08-09 18:31:08 |
| chain | chain:1-354 |
| checksum | AB12F1E917A00A8D |
| comment | FUNCTION Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).SUBUNIT Efficient DNA binding requires dimerization with another bHLH protein.SUBCELLULAR LOCATION The disease is caused by variants affecting the gene represented in this entry. |
| description | recommendedName: fullName evidence="5"Transcription factor ATOH1 alternativeName: fullName evidence="6"Atonal bHLH transcription factor 1 alternativeName: fullName evidence="6"Class A basic helix-loop-helix protein 14 shortName evidence="6"bHLHa14 alternativeName: fullName evidence="6"Helix-loop-helix protein hATH-1 shortName evidence="6"hATH1 alternativeName: fullName evidence="6"Protein atonal homolog 1 |
| geneName | ATOH1 ATH1 BHLHA14 |
| identifier | Q92858 |
| isSequenceChanged | FALSE |
| keyword | Activator Deafness Developmental protein Differentiation DNA-binding Neurogenesis Non-syndromic deafness Nucleus Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | ATOH1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988833] ENSEMBL:ENSG00000172238 ATOH1 [Homo sapiens] |
| secondaryIdentifier | ATOH1_HUMAN Q14CT9 |
| sequenceLength | 354 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:212349] ATOH1 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q92858 ATOH1 (50477)
