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Details on Person UniProt:Q16720 ATP2B3
| Class:Id | ReferenceGeneProduct:50453 |
|---|---|
| _chainChangeLog | chain:1-1220 added on Fri February 6 2015 |
| _displayName | UniProt:Q16720 ATP2B3 |
| _timestamp | 2025-02-21 18:34:06 |
| chain | chain:1-1220 |
| checksum | 03B2BA8A0A33B193 |
| comment | FUNCTION ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels at the presynaptic terminals (PubMed:18029012, PubMed:22912398, PubMed:25953895, PubMed:27035656). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:25953895, PubMed:27035656). May counter-transport protons, but the mechanism and the stoichiometry of this Ca(2+)/H(+) exchange remains to be established (By similarity).CATALYTIC ACTIVITY Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)ACTIVITY REGULATION Down-regulated by YWHAE.SUBUNIT Interacts with PDZD11 (PubMed:12763866). Interacts (via N-terminus) with YWHAE (PubMed:18029012).SUBCELLULAR LOCATION Localized at parallel fiber terminals.ALTERNATIVE PRODUCTS There is a combination of two alternatively spliced domains at N-terminal site A (X and Z) and at C-terminal site C (A, B, E and G). The splice sites have mostly been studied independently. Full isoforms so far detected are isoform XA and isoform XB. Experimental confirmation may be lacking for some isoforms.TISSUE SPECIFICITY Highly expressed in the cerebellum (PubMed:8187550). Expressed in adrenal glands (PubMed:27035656).DEVELOPMENTAL STAGE Expressed in fetal skeletal muscle.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. |
| description | recommendedName: Plasma membrane calcium-transporting ATPase 3 shortName evidence="11"PMCA3 ecNumber evidence="15 16"7.2.2.10 alternativeName: Plasma membrane calcium ATPase isoform 3 alternativeName: Plasma membrane calcium pump isoform 3 |
| geneName | ATP2B3 |
| identifier | Q16720 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing ATP-binding Calcium Calcium transport Calmodulin-binding Cell membrane Cell projection Disease variant Ion transport Magnesium Membrane Metal-binding Neurodegeneration Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Synapse Translocase Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | ATP2B3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002215] ENSEMBL:ENSG00000067842 ATP2B3 [Homo sapiens] |
| secondaryIdentifier | AT2B3_HUMAN B7WNR8 B7WNY5 Q12995 Q16858 |
| sequenceLength | 1220 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:144296] UniProt:Q16720-2 ATP2B3 [Homo sapiens] [ReferenceIsoform:144297] UniProt:Q16720-3 ATP2B3 [Homo sapiens] [ReferenceIsoform:144298] UniProt:Q16720-4 ATP2B3 [Homo sapiens] [ReferenceIsoform:144299] UniProt:Q16720-5 ATP2B3 [Homo sapiens] [ReferenceIsoform:144300] UniProt:Q16720-6 ATP2B3 [Homo sapiens] [ReferenceIsoform:144301] UniProt:Q16720-7 ATP2B3 [Homo sapiens] [ReferenceIsoform:144302] UniProt:Q16720-8 ATP2B3 [Homo sapiens] [ReferenceIsoform:405934] UniProt:Q16720-1 ATP2B3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:418300] ATP2B3 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q16720 ATP2B3 (50453)
