Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person UniProt:P20020 ATP2B1

Class:Id	ReferenceGeneProduct:50449
_chainChangeLog	initiator methionine:1 added on Fri February 6 2015;chain:2-1258 added on Fri February 6 2015;initiator methionine:1 for 50449 removed on Fri Nov 03 2023;initiator methionine: for 50449 added on Fri Nov 03 2023;initiator methionine: for 50449 removed on Fri Aug 15 2025;initiator methionine:1 for 50449 added on Fri Aug 15 2025
_displayName	UniProt:P20020 ATP2B1
_timestamp	2025-08-15 21:51:13
chain	initiator methionine:1 chain:2-1220
checksum	7E75C19B1A501423
comment	FUNCTION Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis (PubMed:35358416). Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (PubMed:29104511). May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles.CATALYTIC ACTIVITY Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)BIOPHYSICOCHEMICAL PROPERTIES Monomer (PubMed:1332771). Dimer (PubMed:1332771). Oligomer (PubMed:1332771). Calmodulin binding (PubMed:1332771). Interacts with PDZD11 (PubMed:12763866). Interacts with SLC35G1 and STIM1; inhibits calcium-transporting ATPase activity after store depletion (PubMed:22084111). Interacts with YWHAE; interacts with the monomeric and dimeric forms of the YWHAE but prefer the monomer form; this interaction inhibits calcium-transporting ATPase activity (PubMed:18029012). Interacts with NPTN; this interaction stabilizes ATP2B1 and increases ATPase activity; this interaction controls T cell calcium homeostasis following T cell activation (PubMed:30190470). Interacts with EPB41; regulates small intestinal calcium absorption through regulation of membrane expression of ATP2B1 (By similarity).INTERACTION Colocalizes with SV2A in photoreceptor synaptic terminals. Colocalizes with NPTN to the immunological synapse. Colocalizes with EPB41 to the basolateral membrane in enterocyte. Preferentially sorted to recycling synaptic vesicles.ALTERNATIVE PRODUCTS Isoform B: Ubiquitously expressed. Isoform C: Found in brain cortex, skeletal muscle and heart muscle. Isoform D: Has only been found in fetal skeletal muscle. Isoform K: Found in small intestine and liver. Abundantly expressed in the endometrial epithelial cells and glandular epithelial cells in early-proliferative phase and early-secretory phases (PubMed:21400627).INDUCTION Up-regulated at the proliferative phase of the mentrual cycle. Up-regulated by estrogen.DOMAIN Isoforms A, C, D and E contain an additional calmodulin-binding subdomain B which is different in the different splice variants and shows pH dependent calmodulin binding properties.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
description	recommendedName: fullName evidence="18"Plasma membrane calcium-transporting ATPase 1 ecNumber evidence="20"7.2.2.10 alternativeName: fullName evidence="17"Plasma membrane calcium ATPase isoform 1 shortName evidence="17"PMCA1 alternativeName: Plasma membrane calcium pump isoform 1
geneName	ATP2B1 PMCA1
identifier	P20020
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative splicing ATP-binding Calcium Calcium transport Calmodulin-binding Cell membrane Cell projection Cytoplasmic vesicle Disease variant Intellectual disability Ion transport Magnesium Membrane Metal-binding Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Synapse Translocase Transmembrane Transmembrane helix Transport
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
name	ATP2B1
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9002811] ENSEMBL:ENSG00000070961 ATP2B1 [Homo sapiens]
secondaryIdentifier	AT2B1_HUMAN Q12992 Q12993 Q13819 Q13820 Q13821 Q16504 Q93082
sequenceLength	1220
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:144269] UniProt:P20020-2 ATP2B1 [Homo sapiens] [ReferenceIsoform:144270] UniProt:P20020-3 ATP2B1 [Homo sapiens] [ReferenceIsoform:144271] UniProt:P20020-4 ATP2B1 [Homo sapiens] [ReferenceIsoform:144272] UniProt:P20020-5 ATP2B1 [Homo sapiens] [ReferenceIsoform:144273] UniProt:P20020-6 ATP2B1 [Homo sapiens] [ReferenceIsoform:403208] UniProt:P20020-1 ATP2B1 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:418301] ATP2B1 [plasma membrane] [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by UniProt:P20020 ATP2B1 (50449)