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Details on Person UniProt:P48201 ATP5MC3
| Class:Id | ReferenceGeneProduct:50437 |
|---|---|
| _chainChangeLog | transit peptide:1-67 added on Fri February 6 2015;chain:68-142 added on Fri February 6 2015 |
| _displayName | UniProt:P48201 ATP5MC3 |
| _timestamp | 2024-11-03 19:55:13 |
| chain | transit peptide:1-67 chain:68-142 |
| checksum | 19EC0D1710A0AA3F |
| comment | FUNCTION Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.SUBUNIT F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Interacts with TMEM70 and TMEM242 (PubMed:33753518).SUBCELLULAR LOCATION Trimethylated by ATPSCKMT at Lys-110. Methylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins. Is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).SIMILARITY Belongs to the ATPase C chain family. |
| description | recommendedName: fullName evidence="7"ATP synthase F(0) complex subunit C3, mitochondrial alternativeName: ATP synthase lipid-binding protein alternativeName: fullName evidence="8"ATP synthase membrane subunit c locus 3 alternativeName: ATP synthase proteolipid P3 alternativeName: ATP synthase proton-transporting mitochondrial F(0) complex subunit C3 alternativeName: ATPase protein 9 alternativeName: ATPase subunit c |
| geneName | ATP5MC3 ATP5G3 |
| identifier | P48201 |
| isSequenceChanged | FALSE |
| keyword | CF(0) Disease variant Dystonia Hereditary spastic paraplegia Hydrogen ion transport Ion transport Lipid-binding Membrane Methylation Mitochondrion Neurodegeneration Proteomics identification Reference proteome Transit peptide Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ATP5MC3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994068] ENSEMBL:ENSG00000154518 ATP5MC3 [Homo sapiens] |
| secondaryIdentifier | AT5G3_HUMAN B2R4Z0 D3DPF0 Q4ZFX7 |
| sequenceLength | 142 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5216110] ATP5MC3 [mitochondrial inner membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P48201 ATP5MC3 (50437)
