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Details on Person UniProt:Q06055 ATP5MC2
| Class:Id | ReferenceGeneProduct:50435 |
|---|---|
| _chainChangeLog | transit peptide:1-66 added on Fri February 6 2015;chain:67-141 added on Fri February 6 2015 |
| _displayName | UniProt:Q06055 ATP5MC2 |
| _timestamp | 2024-11-03 19:40:01 |
| chain | transit peptide:1-66 chain:67-141 |
| checksum | 6E627A504A7AE52D |
| comment | FUNCTION Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.SUBUNIT F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c (PubMed:8328972). Interacts with DNAJC30; interaction is direct (PubMed:30318146).SUBCELLULAR LOCATION Trimethylated by ATPSCKMT at Lys-109. Methylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration.MISCELLANEOUS There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins. Is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).SIMILARITY Belongs to the ATPase C chain family. |
| description | recommendedName: fullName evidence="6"ATP synthase F(0) complex subunit C2, mitochondrial alternativeName: ATP synthase lipid-binding protein alternativeName: fullName evidence="7"ATP synthase membrane subunit c locus 2 alternativeName: ATP synthase proteolipid P2 alternativeName: ATP synthase proton-transporting mitochondrial F(0) complex subunit C2 alternativeName: ATPase protein 9 alternativeName: ATPase subunit c |
| geneName | ATP5MC2 ATP5G2 PSEC0033 |
| identifier | Q06055 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing CF(0) Hydrogen ion transport Ion transport Lipid-binding Membrane Methylation Mitochondrion Proteomics identification Reference proteome Transit peptide Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ATP5MC2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004548] ENSEMBL:ENSG00000135390 ATP5MC2 [Homo sapiens] |
| secondaryIdentifier | AT5G2_HUMAN B3KQQ6 |
| sequenceLength | 141 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:424129] UniProt:Q06055-1 ATP5MC2 [Homo sapiens] [ReferenceIsoform:424130] UniProt:Q06055-2 ATP5MC2 [Homo sapiens] [ReferenceIsoform:424131] UniProt:Q06055-3 ATP5MC2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:5215956] ATP5MC2 [mitochondrial inner membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q06055 ATP5MC2 (50435)
