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Details on Person UniProt:P05496 ATP5MC1
| Class:Id | ReferenceGeneProduct:50433 |
|---|---|
| _chainChangeLog | transit peptide:1-61 added on Fri February 6 2015;chain:62-136 added on Fri February 6 2015 |
| _displayName | UniProt:P05496 ATP5MC1 |
| _timestamp | 2026-02-20 22:41:12 |
| chain | transit peptide:1-61 chain:62-136 |
| checksum | 1AFF1F16BB532647 |
| comment | FUNCTION Subunit c, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). With the subunit a (MT-ATP6), forms the proton-conducting channel in the F(0) domain, that contains two crucial half-channels (inlet and outlet) that facilitate proton movement from the mitochondrial intermembrane space (IMS) into the matrix (PubMed:37244256). Protons are taken up via the inlet half-channel and released through the outlet half-channel, following a Grotthuss mechanism (PubMed:37244256).CATALYTIC ACTIVITY H(+)(in) = H(+)(out)SUBUNIT Homooctamer; the c-ring consists of eight c subunits forming a circle, and each subunit adopts a hairpin shape (PubMed:37244256). Component of the ATP synthase complex composed at least of ATP5F1A/subunit alpha, ATP5F1B/subunit beta, ATP5MC1/subunit c (homooctamer), MT-ATP6/subunit a, MT-ATP8/subunit 8, ATP5ME/subunit e, ATP5MF/subunit f, ATP5MG/subunit g, ATP5MK/subunit k, ATP5MJ/subunit j, ATP5F1C/subunit gamma, ATP5F1D/subunit delta, ATP5F1E/subunit epsilon, ATP5PF/subunit F6, ATP5PB/subunit b, ATP5PD/subunit d, ATP5PO/subunit OSCP (PubMed:37244256). ATP synthase complex consists of a soluble F(1) head domain (subunits alpha(3) and beta(3)) - the catalytic core - and a membrane F(0) domain - the membrane proton channel (subunits c, a, 8, e, f, g, k and j) (PubMed:37244256). These two domains are linked by a central stalk (subunits gamma, delta, and epsilon) rotating inside the F1 region and a stationary peripheral stalk (subunits F6, b, d, and OSCP) (PubMed:37244256). Interacts with TMEM70 (homooligomer form); this interaction facilitates the oligomer formation of subunit c/ATP5MC1 (c-ring) and the c-ring membrane insertion and also protects ATP5MC1 against intramitochondrial proteolysis (PubMed:31652072).INTERACTION Trimethylated by ATPSCKMT at Lys-104. Methylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration.MISCELLANEOUS There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins. Is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).SIMILARITY Belongs to the ATPase C chain family. |
| description | recommendedName: fullName evidence="6"ATP synthase F(0) complex subunit C1, mitochondrial alternativeName: ATP synthase lipid-binding protein alternativeName: fullName evidence="8"ATP synthase membrane subunit c locus 1 alternativeName: ATP synthase proteolipid P1 alternativeName: ATP synthase proton-transporting mitochondrial F(0) complex subunit C1 alternativeName: ATPase protein 9 alternativeName: ATPase subunit c alternativeName: fullName evidence="6"Proton-conducting channel, ATP synthase F(0) complex subunit c |
| geneName | ATP5MC1 ATP5G1 |
| identifier | P05496 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure CF(0) Hydrogen ion transport Ion transport Lipid-binding Membrane Methylation Mitochondrion Proteomics identification Reference proteome Transit peptide Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | ATP5MC1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003392] ENSEMBL:ENSG00000159199 ATP5MC1 [Homo sapiens] |
| secondaryIdentifier | AT5G1_HUMAN |
| sequenceLength | 136 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:164535] ATP5MC1 [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:1267972] ATP5G1(1-136) [mitochondrial intermembrane space] [Homo sapiens] [EntityWithAccessionedSequence:1267993] ATP5G1(1-136) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:1299432] ATP5G1(1-136) [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:8986143] ATP5G1(1-61) [mitochondrial matrix] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P05496 ATP5MC1 (50433)
