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Details on Person UniProt:Q99941 ATF6B
| Class:Id | ReferenceGeneProduct:50427 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-703 added on Fri February 6 2015;chain:2- added on Fri February 6 2015;initiator methionine:1 for 50427 removed on Fri Nov 03 2023;initiator methionine: for 50427 added on Fri Nov 03 2023;initiator methionine: for 50427 removed on Fri Aug 15 2025;initiator methionine:1 for 50427 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q99941 ATF6B |
| _timestamp | 2025-08-15 21:28:29 |
| chain | initiator methionine:1 chain:2-703 chain:2- |
| checksum | B04C7B23E7D83F82 |
| comment | FUNCTION Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 beta), which is embedded in the endoplasmic reticulum membrane (PubMed:11256944). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed:11256944).FUNCTION Transcription factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress (PubMed:11256944). Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE (PubMed:11256944).SUBUNIT Homodimer and heterodimer with ATF6-alpha. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC).INTERACTION Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.ALTERNATIVE PRODUCTS Ubiquitous.DOMAIN The basic domain functions as a nuclear localization signal.DOMAIN The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE.PTM N-glycosylated.PTM During unfolded protein response, a fragment of approximately 60 kDa containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 (MBTPS1, S1P) and site-2 (MBTPS2, S2P) proteases.SIMILARITY Belongs to the bZIP family. ATF subfamily. |
| description | recommendedName: Cyclic AMP-dependent transcription factor ATF-6 beta shortName: cAMP-dependent transcription factor ATF-6 beta alternativeName: Activating transcription factor 6 beta shortName: ATF6-beta alternativeName: Protein G13 alternativeName: cAMP response element-binding protein-related protein shortName: Creb-rp alternativeName: cAMP-responsive element-binding protein-like 1 component recommendedName: Processed cyclic AMP-dependent transcription factor ATF-6 beta /component |
| geneName | ATF6B CREBL1 G13 |
| identifier | Q99941 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Activator Alternative splicing DNA-binding Endoplasmic reticulum Glycoprotein Membrane Nucleus Proteomics identification Reference proteome Signal-anchor Transcription Transcription regulation Transmembrane Transmembrane helix Unfolded protein response |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9015733] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9698430] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | ATF6B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988832] ENSEMBL:ENSG00000213676 ATF6B [Homo sapiens] |
| secondaryIdentifier | ATF6B_HUMAN B0UYX6 Q13269 Q14343 Q14345 Q5SSW7 Q99635 Q99637 Q9H3V9 Q9H3W1 Q9NPL0 |
| sequenceLength | 703 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:144248] UniProt:Q99941-2 ATF6B [Homo sapiens] [ReferenceIsoform:413182] UniProt:Q99941-1 ATF6B [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:8874143] ATF6B(2-398) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8874147] ATF6B(441-703) [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:8874148] ATF6B(2-440) [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:8874154] ATF6B [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:8874171] ATF6B(399-440) [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:8874178] ATF6B(2-398) [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8874179] ATF6B [endoplasmic reticulum membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:8936237] glycosylated residue at 476 [ModifiedResidue:8936242] glycosylated residue at 676 [ModifiedResidue:8936246] glycosylated residue at 627 [ModifiedResidue:8936247] glycosylated residue at 610 [ModifiedResidue:8936249] glycosylated residue at 505 |
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No pathways have been reviewed or authored by UniProt:Q99941 ATF6B (50427)
