Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q8TE59 ADAMTS19
| Class:Id | ReferenceGeneProduct:50423 |
|---|---|
| _chainChangeLog | signal peptide:1-21 added on Fri February 6 2015;propeptide:22-316 added on Fri February 6 2015;chain:317-1207 added on Fri February 6 2015;signal peptide:1-21 for 50423 removed on Fri Aug 15 2025;propeptide:22-316 for 50423 removed on Fri Aug 15 2025;chain:317-1207 for 50423 removed on Fri Aug 15 2025;signal peptide:1-27 for 50423 added on Fri Aug 15 2025;propeptide:28-322 for 50423 added on Fri Aug 15 2025;chain:323-1213 for 50423 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q8TE59 ADAMTS19 |
| _timestamp | 2025-10-31 19:46:25 |
| chain | signal peptide:1-27 propeptide:28-322 chain:323-1213 |
| checksum | A274B4147302F03F |
| comment | COFACTOR Binds 1 zinc ion per subunit.SUBCELLULAR LOCATION Expressed in fetal lung, but not in any adult tissues examined. Expression was detected in an osteosarcoma cDNA library.DOMAIN The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.PTM The precursor is cleaved by a furin endopeptidase.PTM Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).DISEASE The disease is caused by variants affecting the gene represented in this entry. |
| description | recommendedName: A disintegrin and metalloproteinase with thrombospondin motifs 19 shortName: ADAM-TS 19 shortName: ADAM-TS19 shortName: ADAMTS-19 ecNumber: 3.4.24.- |
| geneName | ADAMTS19 |
| identifier | Q8TE59 |
| isSequenceChanged | FALSE |
| keyword | Cleavage on pair of basic residues Disease variant Disulfide bond Extracellular matrix Glycoprotein Hydrolase Metal-binding Metalloprotease Protease Proteomics identification Reference proteome Repeat Secreted Signal Zinc Zymogen |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9970787] Weiser, Joel, 2025-10-31 |
| name | ADAMTS19 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997587] ENSEMBL:ENSG00000145808 ADAMTS19 [Homo sapiens] |
| secondaryIdentifier | ATS19_HUMAN A0A1X7SBR9 |
| sequenceLength | 1213 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5173074] glc-fuc-ADAMTS19 [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:5173079] O-fuc-ADAMTS19 [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:5173161] ADAMTS19 [endoplasmic reticulum lumen] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:5173147] O-fucosyl-L-serine (ChEBI:76521) at unknown position [ModifiedResidue:5173260] O-fucosyl-L-serine at unknown position |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8TE59 ADAMTS19 (50423)
