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Details on Person Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS2)

Class:Id	Reaction:504054
_displayName	Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS2)
_doRelease	TRUE
_timestamp	2025-12-16 18:01:23
catalystActivity	[CatalystActivity:504051] CTP synthase activity of CTPS2 tetramer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643873] CTP synthase activity of CTPS2 tetramer [cytosol] Identification of a cDNA encoding an isoform of human CTP synthetase
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:504056] D'Eustachio, P, 2010-02-05
crossReference	[DatabaseIdentifier:9975911] RHEA:26427
input	[SimpleEntity:29494] UTP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:29472] L-Gln [cytosol] [SimpleEntity:29356] H2O [cytosol]
internalReviewed	[InstanceEdit:9977060] D'Eustachio, Peter, 2025-12-16
literatureReference	[LiteratureReference:200249] Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A [LiteratureReference:504057] Identification of a cDNA encoding an isoform of human CTP synthetase
modified	[InstanceEdit:504062] D'Eustachio, P, 2010-02-05 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9737139] D'Eustachio, Peter, 2021-07-16 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9975916] D'Eustachio, Peter, 2025-12-04 [InstanceEdit:9977061] D'Eustachio, Peter, 2025-12-16 [InstanceEdit:9977063] D'Eustachio, Peter, 2025-12-16
name	Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS2) UTP + L-glutamine + ATP + H2O => CTP + L-glutamate + ADP + phosphate + 2 H(+)
output	[SimpleEntity:110614] CTP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29404] L-Glu [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2010-03-16
reviewed	[InstanceEdit:9977064] D'Eustachio, Peter, 2025-12-16
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104952] R-HSA-504054.6
structureModified	[InstanceEdit:9975916] D'Eustachio, Peter, 2025-12-04
summation	[Summation:504060] Cytosolic CTP synthase 2 (CTPS) catalyzes the reaction of UT...
(hasEvent)	[Pathway:499943] Interconversion of nucleotide di- and triphosphates [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775859] Update Tracker - [Reaction:504054] UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] - v78:[addOutput]
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