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Details on Person UniProt:P11245 NAT2
| Class:Id | ReferenceGeneProduct:50345 |
|---|---|
| _chainChangeLog | chain:1-290 added on Fri February 6 2015 |
| _displayName | UniProt:P11245 NAT2 |
| _timestamp | 2025-02-21 19:04:23 |
| chain | chain:1-290 |
| checksum | FAEE3BC2107F000E |
| comment | FUNCTION Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates (PubMed:12222688, PubMed:7915226). Participates in the detoxification of a plethora of hydrazine and arylamine drugs, and is able to bioactivate several known carcinogens.CATALYTIC ACTIVITY an arylamine + acetyl-CoA = an N-acetylarylamine + CoACATALYTIC ACTIVITY an N-hydroxyarylamine + acetyl-CoA = an N-acetoxyarylamine + CoABIOPHYSICOCHEMICAL PROPERTIES Genetic variations in NAT2 determine the rate of acetylation of various arylamine and heterocyclic amine substrates that include therapeutic and carcinogenic agents. They influence drug therapy response and susceptibility to chemical toxicity [MIM:243400]. Different alleles are known, whose combination defines the rapid, intermediate and slow acetylator phenotypes. Allele NAT2*4 sequence is historically considered as the reference in most publications. The sequence shown in this entry corresponds to the translation of allele NAT2*12A, which is the one represented in the human reference genome (GRCh38/hg38 assembly) and has an arginine at position 268 (Ref.7). The enzyme encoded by allele NAT2*4 differs by the variant p.Arg268Lys (PubMed:2734109). The two alloenzymes have comparable arylamine N-acetyltransferase activity (PubMed:11337936).SIMILARITY Belongs to the arylamine N-acetyltransferase family.SEQUENCE CAUTION NAT alleles |
| description | recommendedName: fullName evidence="23"Arylamine N-acetyltransferase 2 ecNumber evidence="3 13"2.3.1.5 alternativeName: Arylamide acetylase 2 alternativeName: N-acetyltransferase type 2 shortName: NAT-2 alternativeName: fullName evidence="23"N-hydroxyarylamine O-acetyltransferase ecNumber evidence="3 13"2.3.1.118 alternativeName: Polymorphic arylamine N-acetyltransferase shortName: PNAT |
| geneName | NAT2 AAC2 |
| identifier | P11245 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acyltransferase Cytoplasm Direct protein sequencing Proteomics identification Reference proteome Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | NAT2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993472] ENSEMBL:ENSG00000156006 NAT2 [Homo sapiens] |
| secondaryIdentifier | ARY2_HUMAN O43637 O60654 O60655 Q13146 Q16697 Q2MLE4 Q2MLF5 Q2MLG8 Q2MLJ6 Q2MLK4 Q2MLK6 Q2MLN7 Q6LET4 Q86XS0 Q86XS1 Q96KY8 Q96T64 Q96T65 Q9H220 |
| sequenceLength | 290 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:158692] NAT2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:158833] AcC-NAT2 [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:158837] S-acetyl-L-cysteine at 68 |
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No pathways have been reviewed or authored by UniProt:P11245 NAT2 (50345)
